Clinical trials: Diabetes Mellitus, Type I
Type I Diabetes
Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)
The purpose of this study is to evaluate the clinical performance of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in adult patients with Type 1 diabetes mellitus that cannot be controlled with subcutaneous insulin…
- Trial name
- Phoenix CIP347 (NCT06739811)
- Testing
- Implantable Insulin Pump System
- Where
- 11 sites in France, Netherlands
- Volunteers
- 40 people
- Sponsor
- Medtronic MiniMed, Inc.
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 2
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic participants following cataract surgery.
- Trial name
- NCT01872611
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Vehicle, Prednisolone acetate
- Volunteers
- 819 people
- Sponsor
- Alcon Research
Diabetes Mellitus Type 1
Long Term CGM Treatment in Patients With Type 1 Diabetes Treated With Insulin Injections
A keystone in preventing diabetic complications in patients with type 1 diabetes is good glycaemic control. Frequent self-measurements of blood glucose (SMBG) levels have been an essential part of insulin dosing before meals.
- Trial name
- NCT02465411
- Testing
- Dexcom G4 or later generation
- Where
- 15 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
Type 1 Diabetes
A Study of Autologous Induced Islet Body With Type 1 Diabetes
This is a single centre、single arm、open-label study，to investigate the safety and efficacy of Autologous induced islet body With Type 1 diabetes
- Trial name
- NCT03728296
- Testing
- islet body
- Volunteers
- 20 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Type 1 Diabetes, Celiac Disease
Gluten Immunity and Islet Autoimmunity in Type-1 Diabetes
The purpose of this study is to determine whether the immune response causing celiac disease is related to the autoimmune response causing type-1 diabetes.
- Trial name
- NCT01932476
- Testing
- Gluten Challenge
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q4-Atomoxetine
This study is aimed at determining if the drug Atomoxetine (Strattera-used to treat Attention Deficit Hyperactivity Disorder(ADHD) has effects on the body's ability to defend itself against low blood sugar.
- Trial name
- NCT00780650
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 1 Diabetes Mellitus
Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
This Phase 3 study was intended to demonstrate superiority of either Sotagliflozin high dose or low dose versus placebo on glycosylated hemoglobin A1C (A1C) reduction at Week 24 when used as an adjunct in adult participants with…
- Trial name
- inTandem2 (NCT02421510)
- Testing
- Sotagliflozin
- Where
- 96 sites in Austria, Belgium and 15 more
- Volunteers
- 782 people
- Sponsor
- Lexicon Pharmaceuticals
Diabetes Mellitus, Type 1
Improving Diabetes in Emerging Adulthood
This project will test the efficacy of a multi-component behavioral intervention to improve metabolic control among older adolescents and emerging adults (16-21) with T1D, a group with chronic poor metabolic control.
- Trial name
- IDEA (NCT04066959)
- Testing
- Motivational Enhancement System (MES), Question Prompt List (QPL), Text Message Reminders (TXT)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Wayne State University
Diabetes Mellitus
Comparative Measurement of Microcirculation and Other Parameters With the Vital USA VitalDetect™ in Patients With Diabetes Mellitus Type 1 and Type 2 Versus Healthy Participants
The purpose of this clinical study is to optimize the measurement algorithm of the Vital USA VitalDetectTM in measuring the microcirculating blood flow.
- Trial name
- NCT06063759
- Testing
- VitalDetect
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sciema UG
Type 1 Diabetes, Hypoglycemia
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents
Objective: to gain experience in children and younger adolescents with in-home use of an algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycemia, Artificial Pancreas
- Trial name
- PHM3 (NCT02714972)
- Testing
- Hyperglycemia Minimization Algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Jaeb Center for Health Research
Diabete Type 1
Strategy For Assessing The Risk Of Type 1 Diabetes In Pediatric Celiac Patients
Celiac disease (CD) and type 1 diabetes mellitus (T1D) are chronic autoimmune disorders that frequently co-occur, largely due to shared genetic susceptibility, particularly HLA-DQ2 and HLA-DQ8 alleles.
- Trial name
- CARES-T1D (NCT07862101)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Bari
Hypoglycemia, Breastfeeding
Continuous Glucose Monitoring in New Mothers With Type 1 Diabetes
With appropriate day-time carbohydrate intake and insulin dose, the 24 hour glucose levels and prevalence of night-time hypoglycaemia are comparable in breastfeeding new mothers and formula feeding new mothers with type 1…
- Trial name
- NCT02898428
- Testing
- Continuous glucose monitoring (CGM)
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Efficacy and Safety of THDB0206 Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes
This is a 26-week randomized, open-label, multicenter, active-controlled parallel group trial. The purpose of this study is to compare efficacy and safety of THDB0206 injection with insulin lispro injection combined with insulin…
- Trial name
- NCT07282054
- Testing
- THDB0206, Insulin Lispro, Insulin Glargine
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Tonghua Dongbao Pharmaceutical Co.,Ltd
Type1 Diabetes Mellitus
Safety and Efficacy of BC LisPram
This pilot study is a 50-hour randomized, open-label, crossover study in an inpatient setting assessing the safety, pharmacodynamics, pharmacokinetics, and closed-loop efficacy of i) BC LisPram delivery and ii) rapid insulin…
- Trial name
- NCT04972175
- Testing
- 50-Hour Intervention - Rapid Insulin lispro, 50-Hour Intervention - BC LisPram
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Michael Tsoukas
Type 1 Diabetes (T1D), Latent Autoimmune Diabetes in Adult (LADA)
Building and Sustaining Exercise Habits for Adults With Type 1 Diabetes
The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise…
- Conditions
- Type 1 Diabetes (T1D), Latent Autoimmune Diabetes in Adult (LADA), Pancreatitis
- Trial name
- NCT06967701
- Testing
- Exercise program, Self-monitoring
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Type 1 Diabetes Mellitus
Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes
This study will examine the effects of Tirzepatide (TZP), a glucagon-like peptide 1 (GLP1) - gastric inhibitory peptide (GIP) co-agonist, on metabolism in type 1 diabetes (T1D).
- Trial name
- TIRTLE2 (NCT06820281)
- Testing
- Tirzepatide 2.5mg weekly
- Where
- Australia
- Volunteers
- 44 people
- Sponsor
- Victor Chang Cardiac Research Institute
Diabetes, Diabetes Mellitus, Type 1
Changing Diabetes® World Tour
This study is conducted in the Middle East, Northern Africa and Europe. The aim of this study is to contribute to the design of a simple screening strategy for countries in scope, by exploring the association between risk factors…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01437072
- Testing
- No treatment given
- Where
- 3 sites in Portugal, Saudi Arabia and 1 more
- Volunteers
- 8,304 people
- Sponsor
- Novo Nordisk A/S
Insulin Dependent Diabetes Mellitus
Strategies to Minimize the Risk for Insulin Induced Hypertrophy and Its Related Consequences
Hypertrophy caused by insulin has effects that extend beyond just aesthetic concerns. Innovative methods have shown potential in decreasing the chances of hypertrophy and its related issues, including the development of detailed…
- Trial name
- NCT07375875
- Testing
- Group(1) Insulin site injection map
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Mansoura University
Type1 Diabetes
Yale-Harvard Hotel-based Closed-Loop Studies in Children (HY-GRAID)
The aim of this clinical study is to determine the feasibility, safety, and preliminary effectiveness of the Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP) system in pediatric subjects with type 1 diabetes in an…
- Trial name
- HY-GRAID (NCT04255381)
- Testing
- Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Diabetes Mellitus, Insulin-Dependent
Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer
This study will evaluate the safety and effectiveness of a continuous glucose monitor in children with Type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00069628
- Testing
- GlucoWatch® G2™ Biographer (GW2B), Continuous Glucose Monitoring System (CGMS)
- Where
- 6 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research