Clinical trials: Diabetes Mellitus, Type I
Diabetes Type 1
National Epidemiological Study of the Possible Impact of Stress on Glycaemic Control in Patients With Type 1 Diabetes
The EPISTRESS2 study is a one-off cross-sectional epidemiological survey, carried out via an online form in patients with type 1 diabetes followed up by participating investigating centres.
- Trial name
- EPISTRESS2 (NCT06365255)
- Testing
- questionnaires
- Where
- 11 sites in France
- Volunteers
- 1,344 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes Mellitus
An Evaluation of Internet-based Carbohydrate Counting Education for Adolescents With Type 1 Diabetes
Helping individuals with diabetes to control their blood sugars through self-management is an important goal, and counting carbohydrates (CHO) remains a key part of diabetes education and management.
- Trial name
- NCT02462785
- Testing
- In-person Carbohydrate Counting Class, Online Carbohydrate Counting Tutorial
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- The Hospital for Sick Children
Type 1 Diabetes (T1D)
GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes
Blood glucose management in type 1 diabetes (T1D) remains a challenge, with only ~30% of adults within the recommended consensus guidelines.
- Trial name
- AID-JUNCT (NCT06630585)
- Testing
- Tirzepatide
- Where
- 3 sites in Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Bern
Diabetes Mellitus
Safety and Efficacy of CLBS03 in Adolescents With Recent Onset Type 1 Diabetes (The Sanford Project T-Rex Study)
This clinical trial will explore the safety and effect of autologous ex vivo expanded polyclonal regulatory T-cells on beta cell function in patients, aged 8 to 17, with recent onset T1DM.
- Trial name
- NCT02691247
- Testing
- CLBS03 Low Dose, CLBS03 High Dose
- Where
- 15 sites in United States
- Volunteers
- 113 people
- Sponsor
- Lisata Therapeutics, Inc.
Type 1 Diabetes Mellitus
Pediatric Diabetics Type 1 Using InsuPatch
This study is a prospective, single-center, open label, randomized; two-arms cross over study. This is the test protocol for the InsuPatch device, whose purpose is to improve insulin delivery into the blood when the insulin is…
- Trial name
- NCT01368978
- Testing
- InsuPatch
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Insuline Medical Ltd.
Diabetes Mellitus, Type 1, Diabetes Mellitus
Investigating Genetic Risk for Type 1 Diabetes
The objective of this study is to determine the percentage of children with genetic markers putting them at increased risk of developing type 1 diabetes, and to offer the opportunity for these children to be enrolled into a phase…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- INGR1D (NCT03503747)
- Where
- United Kingdom
- Volunteers
- 15,640 people
- Sponsor
- University of Oxford
Type 1 Diabetes Mellitus
Subcutaneous Administration of Teplizumab in Adults With Type 1 Diabetes
The purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of subcutaneously administered teplizumab in adults with relatively recent onset T1DM, greater than 12 weeks and…
- Trial name
- SUBCUE (NCT01189422)
- Volunteers
- 1 people
- Sponsor
- MacroGenics
Stress, Anxiety
Effect of Ear Massage on Stress, Anxiety, and Sleep Quality in Parents of Children With Type 1 Diabetes
The purpose of this clinical trial is to determine the effect of self-administered ear massage on stress, anxiety levels, and sleep quality in parents of children diagnosed with Type 1 diabetes.
- Conditions
- Stress, Anxiety, Sleep Quality
- Trial name
- NCT06829251
- Testing
- Effective Ear Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Mersin University
Type 1 Diabetes Mellitus With Diabetic Gastroparesis, HbA1c
Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T1DM
In this prospective, randomized, open-label, parallel group trial, the safety and efficacy of insulin degludec/insulin aspart (IDegAsp) twice daily will be compared with basal insulin once or twice daily plus pre-prandial insulin…
- Conditions
- Type 1 Diabetes Mellitus With Diabetic Gastroparesis, HbA1c, Time in Range
- Trial name
- NCT04965051
- Testing
- insulin degludec/insulin aspart (IDegAsp), basal insulin plus pre-prandial insulin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus, Type 1
The GlucoPred Investigation II
Diabetes mellitus type 1 (DM1) is an autoimmune metabolic disease in which the insulin producing cells in the pancreas are destroyed and the subject is left totally dependent of external supply of insulin.
- Trial name
- GPI-II (NCT02595580)
- Testing
- Glucopred
- Where
- 2 sites in Norway
- Volunteers
- 16 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
The Characteristics of Different Personal Lancets on Blood Volume and Perceived Pain in Patients With Diabetes Mellitus
A randomized single-blind study with the use of different lancing devices equipped with personal lancets to determine and to compare the amount of capillary blood volume and perceived pain after a single lancing of the fingertip.
- Trial name
- NCT04253431
- Testing
- Droplet lancing device (HTL-Strefa S.A.), Microlet 2 lancing device (Bayer), OneTouch Delicia lancing device (LifeScan)
- Volunteers
- 60 people
- Sponsor
- HTL-Strefa S.A.
Diabetes Mellitus, Type 1
Insulin Glulisine, Diabetes Mellitus Type 1
To provide local data on efficacy and safety of insulin glulisine in patients with Type 1 Diabetes Mellitus receiving insulin glargine as basic insulin therapy
- Trial name
- NCT00397553
- Testing
- Insulin glulisine
- Where
- Russia
- Volunteers
- 104 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus
A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (USA)- DIAPREVENT
The intended purpose of this study was to determine whether Diamyd (rhGAD65 formulated in alum) is effective in preserving the body's own insulin producing capacity in patients recently diagnosed with type 1 diabetes.
- Trial name
- NCT00751842
- Testing
- rhGAD65
- Where
- 43 sites in United States
- Volunteers
- 331 people
- Sponsor
- Diamyd Therapeutics AB
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics
The purpose of this study is to demonstrate the performance of the Disposable Sensor (DS5) in subjects age 2 - 80 years, for the span of 170 hours (7 days).
- Trial name
- NCT04436822
- Testing
- Continuous Glucose Monitoring
- Where
- 18 sites in United States, China
- Volunteers
- 317 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
The Postprandial Hypo-Avoid Study
The objective of the study is to evaluate whether pre-exercise administration of low-dose subcutaneous glucagon prevents or attenuates exercise-induced declines in plasma glucose concentration during and after moderate-intensity…
- Trial name
- NCT07427251
- Testing
- Low-Dose Glucagon, Glucose Arm
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Type 1
CGM Precision and Glycaemic Variability
Use of devices for continuous monitoring of the blood sugar is valuable for people with diabetes to understand their disease and to help prevent low blood sugar.
- Trial name
- NCT03842683
- Testing
- CGM
- Volunteers
- 472 people
- Sponsor
- Peter Vestergaard
Type 1 Diabetes Mellitus
Nutritional Intervention to Prevent Diabetes
Type 1 Diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN06 (NCT00333554)
- Testing
- DHA Treatment
- Where
- 9 sites in United States
- Volunteers
- 99 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
PS230005 Control-IQ 1.5 Post-Approval Study
This 522 post-market surveillance study is a single-arm, decentralized prospective observational cohort study designed to collect safety data on Control-IQ technology v1.5 in children with type 1 diabetes ages 2 to <6 years old.
- Trial name
- NCT06717451
- Testing
- Control-IQ Technology v1.5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
LSCI and Thermography in Diabetic Foot Patients Affected by Ulcer(s): (MY-FOOT-B)
The objective of this observational study is to predict healing at 26 weeks after the first visit in patients affected by the first ulcer, by means of combined data monitoring of Laser Speckle Contrast Imaging (LSCI) and…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Ulcer Foot
- Trial name
- MY-FOOT-B (NCT05791929)
- Sponsor
- Mario Negri Institute for Pharmacological Research
Diabetes Mellitus, Type 1, Type 1 Diabetes
Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Postprandial Hyperglycemia
- Trial name
- NCT04243629
- Testing
- Rapid-Acting Insulin, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University
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