Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes Mellitus
Steroid-free and Long-term Calcineurin-free Trial in Islet Cell Transplantation
The purposes of this study are: 1. To reverse hyperglycemia and insulin dependency in patients with type 1 diabetes mellitus through islet transplantation utilizing steroid free, calcineurin-inhibitor free immunosuppression. 2.
- Trial name
- NCT00315627
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodolfo Alejandro
Hypertension
Glucose Optimisation With Angiotensin II Antagonist Losartan (GOAAL)
To determine if angiotensin-II AT-1 receptor blockade(ARB) may improve insulin sensitivity assessed by the hyperinsulinaemic isoglycaemic glucose clamp, more than CCB therapy at a comparable dose with regards to the blood…
- Trial name
- NCT00237588
- Testing
- Amlodipine 10 mg or Losartan 100 mg + Amlodipine 5 mg
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Ullevaal University Hospital
Wolfram Syndrome 1, Optic Atrophies, Hereditary
Does Recessive Optic Atrophy Due to WFS1 Exist?
All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study.
- Trial name
- NCT07336966
- Testing
- analyse study
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
Diabetes Mellitus, Type 1
Research Study in Japan to Compare Dasiglucagon With Glucagon in Treating Very Low Levels of Blood Sugar in Asian Adults With Type 1 Diabetes and Testing of Dasiglucagon for the Same Condition in Japanese Adolescents
This study will be looking to confirm the effect of dasiglucagon when compared with glucagon for treating very low sugar levels in Asian adults with T1D and the effect of dasiglucagon in Japanese adolescents with T1D.
- Trial name
- NCT06588504
- Testing
- Dasiglucagon, Glucagon
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Diabetes (Insulin-requiring, Type 1 or Type 2), Insomnia Type; Sleep Disorder
Indonesian-Language Application-Based Guided Imagery Therapy for Insomnia and Glycemic Control in Diabetic Patients
The goal of this clinical trial is to learn if guided imagery therapy using mobile application in Indonesian language can improve sleep quality and lower fasting blood glucose levels in diabetics patients who have problems with…
- Conditions
- Diabetes (Insulin-requiring, Type 1 or Type 2), Insomnia Type; Sleep Disorder, Fasting Plasma Glucose
- Trial name
- NCT07141940
- Testing
- Indonesian-language application-based auditory guided imagery therapy, Psychoeducation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Type 1 Diabetes
Compliance to Vaccination in Children With Diabetes and Their Siblings
This is an observational, single-center, cross-sectional study about adherence to both obligatory and recommended vaccination in children with Type 1 Diabetes Mellitus and their siblings.
- Trial name
- NCT07471906
- Testing
- Compliance to vaccination schedule
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes
In Clinic Evaluation of the PLGM Feature
This study is a multi-center, single arm and in-clinic study to evaluate the safety of the PLGM System and its algorithm with the Enlite 3 Sensor.
- Trial name
- PLGM (NCT02130284)
- Testing
- Predictive Low Glucose Management Feature in Insulin pump
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
Single Dose Study With a New Insulin Glargine Formulation and Lantus® in Japanese Patients With Type 1 Diabetes Mellitus
Primary Objective: To compare the pharmacodynamic properties of two different doses of a new insulin glargine formulation with 0.4 U/kg Lantus® Secondary Objective: To compare the pharmacokinetic properties of two different doses…
- Trial name
- NCT01493115
- Testing
- Insulin glargine HOE901, Insulin glargine - New formulation HOE901
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Sanofi
Type 1 Diabetes
Pancreatic Calcium Handling in Islet Beta Cells in Patients With Type 1 Diabetes Mellitus
Approximately 400,000 people are living with type 1 diabetes mellitus (T1DM) in the United Kingdom: one of the highest rates in the world.
- Trial name
- Pancreas MEMRI (NCT05298735)
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Effect of Acute Hypoglycaemia on Cognitive Function and Brain Activation Patterns in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to compare cognitive function and associated brain activation patterns during an acute hypoglycaemic episode and during euglycaemia (normal blood glucose concentration).
- Trial name
- NCT01789593
- Testing
- glucose clamp
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Diabetes Distress
UK MyREMEDY Clinical Trial
The UK MyREMEDY study investigates whether MyDiaMate, an online self-help program, can effectively improve the mental health of adults with type 1 diabetes compared to those receiving care as usual.
- Trial name
- UK-MyREMEDY (NCT06448338)
- Testing
- MyDiaMate
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- King's College London
Diabetes Mellitus, Type 1
YpsoPump Occlusion Detection Algorithm: Collection of Real-world Data for In-silico Evaluation of a New Software Algorithm to Refine Occlusion Detection in Subjects With Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion
A common difficulty related to the insulin pumps are occlusions of the insulin infusion set (IIS). This study aims to evaluate the performance of a new software algorithm to detect catheter-occlusion in silico in order to refine…
- Trial name
- NCT05096325
- Testing
- YpsoPump® insulin pump system
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 40 people
- Sponsor
- mylife Diabetes Care AG
Type 1 Diabetes
T1D Risk Assessment in Kids With Relatives
The purpose of this study is to determine whether early immunological markers (activation of autoreactive T lymphocytes) precede and are predictive of the appearance of autoantibodies in children born from type 1 diabetic parents.
- Trial name
- TRAKR (NCT02184676)
- Testing
- Analysis of early immune modifications, Collection of clinical and socio-demographic data
- Where
- France
- Volunteers
- 512 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes
The Impact of Continuous Glucose Monitoring Use on Sleep in Parents of Children With Type 1 Diabetes Mellitus
The purpose of this prospective exploratory study is to compare sleep quality and sleep-wake patterns in parents of children with type 1 diabetes (T1D) before and several weeks after initiating using real-time continuous glucose…
- Trial name
- NCT01425255
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Type 1 Diabetes Mellitus
Lypo-hypertrofia Characterization in Diabetes
Aim/hypothesis: Subcutaneous insulin absorption is one of the factors which strongly influence blood sugar control in patients with diabetes mellitus on insulin therapy.
- Trial name
- NCT02278926
- Testing
- Ultrasound, Tapping and body inspection to define the area of insulin injection
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Type 1 Diabetes, Children
Cord Blood Infusion for Type 1 Diabetes Mellitus (T1DM)
Type 1 diabetes (T1D) is still associated with tremendous morbidity and premature mortality. Patients require multiple daily insulin injections throughout their lives as well as close monitoring of their diet and blood sugar…
- Trial name
- NCT00989547
- Testing
- Umbilical Cord Blood VITA 34
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Type 1 Diabetes
Glycemic Response to Road Cycling in Type 1 Diabetes
The purpose of this study is to assess the glycemic response to cycling road races (using continuous glucose monitoring ) in elite athletes with type 1 diabetes and non-diabetic controls.
- Trial name
- NCT01398826
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Team Type 1, Inc.
Glucose Lowering
To Assess the Pharmacokinetics of AZD1656 and Its Metabolite in Type 2 Diabetes Mellitus Patients
To assess the pharmacokinetics of AZD1656, and its metabolite, in type 2 diabetes mellitus patients with varying degrees of renal impairment and to compare the results with those in patients with normal renal function.
- Trial name
- NCT01069926
- Testing
- AZD1656
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- AstraZeneca
Genetic Variation, Diabetes
Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus
The aim of the project is to positionally clone susceptibility genes for NIDDM. Patients will be ascertained in Finland from previous health surveys and hospital discharge records.
- Trial name
- NCT00339885
- Where
- 4 sites in Finland, Norway
- Volunteers
- 32,379 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Diabetic Foot Disease, Diabetic Foot Infection
Continuous Monitoring of Plantar Temperature Variations Using Connected Insoles and a Mobile Application for Diabetic Foot.
The goal of this clinical trial is to evaluate the performance of a self-monitoring system (Solsius SelfCare) to detect pre-ulcerative clinical abnormalities in adults living with type 1 or 2 diabetes at high podiatric risk…
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Foot Infections, Diabete Type 1
- Trial name
- DIAFOOTEM (NCT07910721)
- Testing
- Solsius SelfCare
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Solsius
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