Clinical trials: Diabetes Mellitus, Type I
Diabetes Mellitus, Type 1
Type 1 Diabetes Aerobic and Resistance Exercise (T1-DARE)
This is a randomized controlled trial evaluating different exercise modalities in previously inactive subjects with type 1 diabetes.
- Trial name
- NCT00148538
- Testing
- Resistance and/or Aerobic Exercise
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Hospital Research Institute
Diabetes Mellitus
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes
Defects in insulin secretion are central to the pathogenesis of type 2 diabetes (T2D) but the molecular basis and physiological consequences of those defects are poorly understood, impeding efforts to develop novel therapeutic…
- Trial name
- DIVA-Exeter (NCT02505308)
- Testing
- Glucose-Potentiated Arginine-Induced Insulin Secretion
- Where
- 2 sites in United Kingdom
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Diabetes Mellitus, Type 1
Glucose Response of G-Pen (Glucagon Injection) in Pediatric T1D Patients
This is a sequential efficacy and safety study in pediatric patients with type 1 diabetes. Subjects will be administered insulin to induce a low normal glycemic state and will then receive an age-appropriate dose of G-Pen…
- Trial name
- NCT03091673
- Testing
- Glucagon
- Where
- 7 sites in United States
- Volunteers
- 31 people
- Sponsor
- Xeris Pharmaceuticals
Diabetes Mellitus, Type 1
Glulisine + Lantus in Type I Patients
To evaluate the efficacy (in terms of change HbA1c from baseline to endpoint) and safety (in terms of adverse events, clinical chemistry, lipids, hematology) of insulin glulisine (HMR 1964) in subjects with type I diabetes…
- Trial name
- NCT00545337
- Testing
- Insuline glulisine
- Where
- Ukraine
- Volunteers
- 60 people
- Sponsor
- Sanofi
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus
This trial is conducted in Africa, Asia, Europe and the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of insulin degludec in children and adolescents with type 1 diabetes mellitus.
- Trial name
- BEGIN™ (NCT01513473)
- Testing
- insulin degludec, insulin detemir, insulin aspart
- Where
- 81 sites in United States, Bulgaria and 10 more
- Volunteers
- 350 people
- Sponsor
- Novo Nordisk A/S
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes
Cardiovascular Disease Risk in Children With Type 1 Diabetes Mellitus
Epicardial fat thickness, carotid intima-media thickness, and augmentation index from arterial stiffness indicators are increased in children with T1DM compared to the healthy control group.
- Trial name
- NCT06356051
- Testing
- Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Type 1 Diabetes
Initial Testing of the Diabeloop Algorithm in T1D Patients on Pump Therapy Over the Prandial Period and Physical Activity.
The main objective is to assess if the Diabeloop algorithm provides better glycemic control than a "manual" usual algorithm of patients with type 1 diabetes treated by insulin pump during meals, and during activity qualified…
- Trial name
- DiabeloopWP6-0 (NCT01754181)
- Testing
- Insulin
- Where
- 3 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type1diabetes, Covid19
Covid-19 Pandemic: Patients' Experience in T1D
Given the current situation with COVID-19 declared pandemic on March 11, 2020 and the requirement for physical distancing and to limit social interactions, and for some, to quarantine, the investigators will survey patients…
- Trial name
- NCT04384471
- Testing
- Online survey
- Where
- Canada
- Volunteers
- 384 people
- Sponsor
- McGill University
Diabetes Mellitus
Sports Participation in Children and Adolescents With Type 1 Diabetes Mellitus
On the basis of a questionnaire the participation at sports activities of children and adolescents with type 1 diabetes mellitus will be studied.
- Trial name
- NCT03291834
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Jessa Hospital
Diabetic Retinopathy, Diabetic Macular Edema
Evaluation of NeoRetina Artificial Intelligence Algorithm for the Screening of Diabetic Retinopathy at the CHUM
This prospective study aims to validate if NeoRetina, an artificial intelligence algorithm developped by DIAGNOS Inc. and trained to automatically detect the presence of diabetic retinopathy (DR) by the analysis of macula…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Diabetic Maculopathy
- Trial name
- DR-NeoRetina (NCT04699864)
- Testing
- Screening of DR and DME with artificial intelligence using NeoRetina, Routine ophthalmological evaluation of DR and DME, Manual grading of DR and DME by CHUM ophthalmologists based on retinal photographies acquired by Diagnos
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Type 1 Diabetes
Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy
"Closed loop artificial pancreas" systems have been under development for the control of blood sugars in those living with diabetes.
- Trial name
- NCT01945099
- Testing
- ePID closed loop system, hyaluronidase, Lispro-PH20
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Long-standing Type 1 Diabetes Mellitus
An Open Label, Pilot Investigation, to Assess the Safety and Efficacy of Transplantation of Macro-encapsulated Human Islets Within the Bioartificial Pancreas Beta-Air in Patients With Type 1 Diabetes Mellitus
The primary objective of this clinical investigation is to investigate the safety of implantation of the human islet containing device Beta-Air in type 1 diabetic subjects.
- Trial name
- NCT02064309
- Testing
- Beta-Air device for encapsulation of transplanted human islets
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes Mellitus
Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes Mellitus
The purpose of this study is to determine whether treatment with CTLA4-Ig (Abatacept) in individuals with new onset T1DM will improve insulin secretion (C-peptide production) compared to placebo.
- Trial name
- TN09 (NCT00505375)
- Testing
- CTLA-4 Ig
- Where
- 13 sites in United States, Canada
- Volunteers
- 112 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Virtual Reality
Virtual Reality and Children With Type 1 Diabetes
For children with type 1 diabetes (T1D), pain and needle phobia can cause postponing of changes in insulin pump infusion sets and continuous glucose monitors, and thus worsen glycemic control.
- Trial name
- NCT05883267
- Testing
- Virtual reality glasses, Vocal-guided affective imagery
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes
Impact of a Diabetes Camp on Glycemic Control Among Children and Adolescents Living With Type 1 Diabetes in Cameroon
Therapeutic education is central to the management of diabetes, especially in children and adolescents. Camps represent an ideal environment for education.
- Trial name
- NCT02632032
- Testing
- Insulin
- Volunteers
- 46 people
- Sponsor
- Yaounde Central Hospital
Type 1 Diabetes
CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Longitudinal Study
Glycaemic control is an important aspect of Type 1 diabetes (T1D) management for diabetologists and patients alike. Evidence suggests continuous subcutaneous insulin infusion (CSII) is an effective method of achieving this.
- Trial name
- NCT02258932
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Liverpool John Moores University
Type 1 Diabetes, Insulin Pump Therapy
Impact of Hybrid Closed Loop Systems in People With Type I Diabetes
Type 1 diabetes requires people with type 1 diabetes to constantly monitor their blood glucose and adjust their insulin doses to try and keep glucose levels in range.
- Conditions
- Type 1 Diabetes, Insulin Pump Therapy, Patient Reported Outcomes
- Trial name
- ProHCL (NCT05348499)
- Testing
- Questionnaire/Interview
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Leicester
Diabetes, Diabete Type 2
Native American Diabetes Project
This research study is for American Indian and Alaska Native (AIAN) people with diabetes in Los Angeles County, California. Participants (people who join the study) are signed up for a program that includes healthy meals, online…
- Conditions
- Diabetes, Diabete Type 2, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NADP (NCT05088616)
- Testing
- Virtual Diabetes Wellness Classes and Medically Tailored Meals
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Southern California
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus
This open-label, multicenter study is designed to investigate the clinical utility and safety of pramlintide treatment in subjects with type 1 and type 2 diabetes who are failing to achieve the desired level of glycemic control…
- Trial name
- NCT00108004
- Testing
- pramlintide acetate
- Where
- 48 sites in United States
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
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