Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes, Insulin Therapy
Study on the Use of the Insulin Pump Tandem X:2 With Control IQ Algorithm - Update
The aim of this observational clinical trial is to obtain data on the safety, efficacy and satisfaction of the Tandem T:Slim X:2 Pump System in patients with type 1 diabetes.
- Trial name
- UNIQUE (NCT05118945)
- Testing
- Insulin pump Tandem: t:slim X2
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Diabetes Mellitus, Adult-Onset
Classification of Adult-onset Diabetes in Five Subgroups in Pakistani Population
This study aims to classify adult-onset diabetes patients into distinct data-driven clusters, such as severe insulin-deficient, severe insulin-resistant, mild obesity-related, and mild age-related diabetes, based on clinical and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Adult-Onset, Diabetes Mellitus Type 1 and 2
- Trial name
- NCT06706609
- Volunteers
- 394 people
- Sponsor
- Getz Pharma
Sleep EEG
EEG Changes of type1 Diabetes During Sleep -Insulin Induced Hypoglycemia
Hypoglycaemia is associated with characteristic changes in the EEG with the appearance of slow frequency waves. In a recent study the investigators have shown that these changes can be recorded from subcutaneous electrodes and…
- Trial name
- sleep (NCT01237509)
- Testing
- Hypo device
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- UNEEG Medical A/S
Type 1 Diabetes
Adaptive Study of IL-2 Dose Frequency on Regulatory T Cells in Type 1 Diabetes
Type 1 diabetes (T1D) is the most common severe autoimmune disease worldwide and is caused by the body's immune destruction of its own insulin producing pancreatic beta cells leading to insulin deficiency and development of…
- Trial name
- DILfrequency (NCT02265809)
- Testing
- Aldesleukin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type 1 Diabetes
Glucose Variability in Type 1 Diabetes and Its Effect on Factors That Influence New Vessel Formation
The aim of the study is to see how glycaemic control and glycaemic variability affect levels of HIF, VEGF, erythropoietin and cortisol in Paediatric Type 1 diabetics on insulin pump therapy.
- Trial name
- INDIGO 2 (NCT01429467)
- Testing
- Continuous Glucose Monitor (CGM) and Telemedicine (Enlite Guardian real-time system Medtronic®)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Dundee
Stage 1 Diabetes Mellitus, Type 1
GLP-1 RA for Stage 1 Type 1 Diabetes
This study seeks to evaluate the hormone responses of insulin, c-peptide, glucagon, and incretins to semaglutide, a GLP-1 receptor agonist therapy, in individuals with stage 1 type 1 diabetes.
- Trial name
- NCT07430332
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Type 1 Diabetes Mellitus
Adolescent Self-Care and Knowledge Education in Diabetes--Improved by Texting
This study is a randomized controlled trial assessing diabetes knowledge (using a Mercy-What I Know About Diabetes Test (MWIKAD) validated survey) and self-care practices (using a validated Self-management of Type 1…
- Trial name
- ASKED-IT (NCT03241212)
- Testing
- Texting
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes, Diabetes Mellitus, Type 1
Investigation of Pain During Subcutaneous Injections With Different Injection Speed and Volume Combinations
This trial is conducted in Europe. The aim of this trial is to assess and describe the pain in relation to subcutaneous (under the skin) injection of different combinations of injection speed and volume with respect to acceptance…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT01680328
- Testing
- 19 injections, sodium chloride 0.9% solution
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Patient-Centered Decision Support to Improve Diabetes Management in Pre-Teens and Adolescents With Type 1 Diabetes
Investigators propose to study an intervention that will provide patient-centered, automated decision support to diabetes providers with the goals of improving adherence to medical recommendations (both patients and providers)…
- Trial name
- CHICAT1 (NCT03084900)
- Testing
- Arm 1
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes Mellitus, Type 1
Education Effectiveness for Type 1 Diabetes Mellitus on Insulin Pump Therapy
The purpose of this study is to assess the effectiveness of structured group education on glycemic control and Quality of Life (QoL) among users of continuous subcutaneous insulin infusions (CSII).
- Trial name
- EASEDIAP (NCT02423993)
- Testing
- Education by structured programme, CSII, CGM-RT
- Volunteers
- 77 people
- Sponsor
- Endocrinology Research Centre, Moscow
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Insulin-Dependent
Evaluation of the Effect of the InsuPatch Device on Insulin Pharmacokinetics in Clamp Studies
The study is a prospective, multi-center, open label, randomized; two-arms cross over study. This is the test protocol for the InsuPatch device, whose purpose is to improve insulin delivery into the blood when the insulin is…
- Trial name
- NCT01216618
- Testing
- InsuPatch
- Where
- 3 sites in United States, Israel
- Volunteers
- 55 people
- Sponsor
- Insuline Medical Ltd.
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Improving Postprandial Glycaemia by a New Developed Closed-loop Control System - Closedloop4meals
Achieving near-normoglycemia has been established as the main objective for most patients with diabetes. However, postprandial glucose control is a challenging issue in everyday diabetes care.
- Trial name
- CL4M-Controls (NCT02100488)
- Testing
- Closed-loop insulin infusion system, Open-loop insulin infusion system
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Diabetic Pregnancy, Insulin Resistance
Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.
The study investigates whether additional metformin medication in combination with regular insulin treatment will decrease the need of insulin for women with diabetes mellitus type 1 during pregnancy.
- Conditions
- Diabetic Pregnancy, Insulin Resistance, Type1diabetes
- Trial name
- NCT03765359
- Testing
- metforminhydrochloride
- Where
- 5 sites in Finland
- Volunteers
- 101 people
- Sponsor
- Tampere University Hospital
Type 1 Diabetes, Obesity
Intermittent Fasting in Adults With Type 1 Diabetes
The majority of adults with type 1 diabetes (T1DM) have either overweight or obesity. As such, dietary management has been recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in…
- Trial name
- NCT06134986
- Testing
- Time restricted eating, Daily calorie restriction
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois Chicago
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 1 or Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to evaluate the efficacy and safety of biphasic insulin aspart 30 in subjects with type 1 or type 2 diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01467323
- Testing
- biphasic insulin aspart, biphasic human insulin
- Where
- 37 sites in Austria, Germany and 3 more
- Volunteers
- 303 people
- Sponsor
- Novo Nordisk A/S
Healthy, Type 1 Diabetes Mellitus
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)
The main purpose of this study is to look at the amount of the study drug LY3938577 that gets into the blood stream and how long it takes the body to get rid of it.
- Trial name
- NCT06280703
- Testing
- LY3938577, Insulin Degludec, Insulin Lispro
- Where
- Germany
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (The CGM TIME Trial)
The investigators hypothesize that REAL-Time Continuous Glucose Monitoring (RT-CGM) will be more effective if introduced in children and adolescents with established diabetes at the same time as they are starting pump therapy.
- Trial name
- NCT01295788
- Testing
- Simultaneous RT-CGM and Pump Initiation, Delayed Initiation of RT-CGM
- Where
- 5 sites in Canada
- Volunteers
- 144 people
- Sponsor
- Children's Hospital of Eastern Ontario
Type 1 Diabetes Mellitus, Hypoglycemia
Hypoglycaemia Awareness Restoration Programme
Insulin treatment for type 1 diabetes inevitably carries risk of hypoglycaemia (low blood sugar) which can be severe enough to cause coma, seizure, even death.
- Trial name
- HARPdoc (NCT02940873)
- Testing
- HARPdoc courses, BGAT courses
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 99 people
- Sponsor
- King's College London
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