Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Type 1 Diabetes Mellitus
Best Timing of Insulin Bolus Before Meals of Different Contents
Post-meal glucose excursions may contribute to the development of diabetes-related complications. These glucose excursions are affected by the food content of the meal and the timing of insulin injection (or insulin pump-bolus)…
- Trial name
- NCT01406496
- Testing
- insulin
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Type 1 Diabetes Mellitus
T1DM Immunotherapy Using Polyclonal Tregs + IL-2
The purpose of this study is to assess the safety of Tregs + IL-2 and survival of Tregs in patients with recent onset T1DM who receive infusions of autologous Tregs + IL-2.
- Trial name
- TILT (NCT02772679)
- Testing
- PolyTregs+IL-2
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Jeffrey Bluestone
Non-Insulin Dependent Diabetes Mellitus
Magnesium Treatment of Inflammation in Disorders of Glucose Homeostasis
In most diabetic patients where low blood magnesium levels occur the important depletion of cellular levels is usually not measured.
- Trial name
- MagInGlu (NCT01980459)
- Testing
- magnesium lactate
- Where
- Kuwait
- Volunteers
- 47 people
- Sponsor
- George Washington University
NIDDM
Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Angiotensin Converting Enzyme 2 (ACE2): Diabetic Patients Treated With Antihypertensive Drugs
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) antagonist, Candesartan.
- Trial name
- NCT00192803
- Testing
- candesartan
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Diabetes Mellitus
Post-Market Clinical Follow-Up of the CT3 Series Continuous Glucose Monitoring System: A 14-Day Observational Study Assessing Accuracy, Safety, and Glucose Control in Patients With Type 1 and Type 2 Diabetes Mellitus
Post market Clinical follow-up of the CT3 Series Continuous Glucose Monitoring System: A 14-Day Observational Study Assessing Accuracy, Safety, and Glucose Control in patients with Type 1 and Type 2 Diabetes Mellitus
- Trial name
- NCT07122180
- Testing
- CT3 Series Continuous Glucose Monitoring System:
- Where
- Latvia
- Volunteers
- 72 people
- Sponsor
- MDCECRO LLC
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format,
In previous studies, the investigators tested the feasibility of a bi-hormonal reactive closed loop system without mealtime announcement.
- Trial name
- APPEL5 (NCT03858062)
- Testing
- Insulin pump therapy (with or without glucose sensor), Artificial pancreas (Inreda Diabetic)
- Where
- 2 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- J.H. DeVries
Contingent Versus Noncontingent Incentives
Incentives for Internet-based Adherence to SMBG for Teens With T1D
Self-management of diabetes can result in long-term benefits, such as delaying or preventing the development of a number of unnecessary health complications, and can even reduce the chances of premature death.
- Trial name
- NCT02638246
- Testing
- Internet-delivered, Incentive-based intervention + Motivational Interviewing, Internet-delivered, non-contingent incentives + Motivational Interviewing
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rowan University
Type 1 Diabetes Mellitus
Managing Insulin Pumps for Exercise - Study 1
People with Type 1 Diabetes Mellitus (T1DM) like to take part in sport and exercise, but problems with metabolism and blood glucose control can make this difficult.
- Trial name
- NCT01401127
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Pre-Symptomatic Type 1 Diabetes
A Study to Evaluate SIMPONI (Golimumab) Therapy in Children, Adolescents and Young Adults With Pre-Symptomatic Type 1 Diabetes
The purpose of this study is to determine the safety and tolerability of golimumab in children, adolescents, and young adults with pre-symptomatic stage 2 type 1 diabetes mellitus (T1D).
- Trial name
- NCT03298542
- Testing
- Golimumab
- Where
- 8 sites in United States, Finland and 1 more
- Volunteers
- 8 people
- Sponsor
- Janssen Research & Development, LLC
Type 1 Diabetes Mellitus
Psychiatric Comorbidities in Type 1 Diabetes Mellitus.
This study aimed to assess the prevalence of psychiatric comorbidities in children and adolescents with diabetes mellitus type 1. Assessing the impact of diabetes mellitus type 1 on quality of life.
- Trial name
- NCT06586879
- Volunteers
- 220 people
- Sponsor
- Assiut University
Type 1 Diabetes
Clinical Characteristics of People With Long-term Type 1 Diabetes
Type 1 diabetes (T1D) is characterized by absolute insulin deficiency. Although the discovery and application of exogenous insulin has prolonged the lifespan of T1D patients, the chronic diabetic complications caused by long-term…
- Trial name
- NCT05359796
- Testing
- Chronic hyperglycemia, Residual islet function, Genetic variation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes
The ADHERENCE Index - the Indicator of Effective Coping With the Requirements of the Disease of Children and Adolescents With Type 1 Diabetes
The aim of the research is to develop a mathematical model called ADHERENCE index, and to evaluate its effectiveness.
- Trial name
- ADHERENCE (NCT01580462)
- Testing
- Observational study
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Diabetes Mellitus, Type 1, Epilepsy
Impact of Parental Perfectionistic Cognitions Self-compassion Intervention Effects on Shame in Child Health Context
Parents of children with long-term health conditions (LTCs) can experience shame related to parenting. Whilst self-compassion interventions (SCIs) can reduce parental shame, this has not been studied with parents of children with…
- Conditions
- Diabetes Mellitus, Type 1, Epilepsy, Asthma, Shame
- Trial name
- NCT03504605
- Testing
- Online self-compassion intervention
- Where
- United Kingdom
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Type 1 Diabetes Mellitus, Type 1 Diabetes
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to establish the safety and efficacy of multiple administrations of PROCHYMAL® in participants recently diagnosed with type 1 diabetes mellitus.
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Insulin-Dependent, Juvenile Diabetes
- Trial name
- NCT00690066
- Testing
- PROCHYMAL®
- Where
- 20 sites in United States
- Volunteers
- 63 people
- Sponsor
- Mesoblast, Inc.
Type 1 Diabetes, type1diabetes
Reducing Innate Inflammation in New Onset Type 1 Diabetes
This study aims to determine whether Lactiplantibacillus plantarum 299v (Lp299v) supplementation will reduce systemic inflammation and prolong residual beta cell function in individuals newly diagnosed with Type 1 diabetes.
- Conditions
- Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
- Trial name
- NCT04335656
- Testing
- Lactiplantibacillus plantarum
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes (T1D)
Universal Type 1 Diabetes Screening in Pediatrics
This study examines how population-based screening for type 1 diabetes (T1D) using islet autoantibodies (i.e., immune system proteins) can be incorporated into pediatric primary care during routine well-child visits.
- Trial name
- NCT07612475
- Testing
- Set of implementation strategies
- Where
- 8 sites in United States
- Volunteers
- 9,500 people
- Sponsor
- Northwestern University
Type 1 Diabetes Mellitus
FIasp® vs. Novolog® in Type 1 Diabetics Using 670G Medtronic Pump
This is an exploratory, single-center, randomized, open label, active-controlled, complete cross-over trial comparing safety and efficacy of Fiasp® versus NovoLog® when used in the Medtronic MiniMed 670G system in subjects with…
- Trial name
- NCT03977727
- Testing
- Fiasp®, Novolog®, 670G hybrid closed loop continuous subcutaneous insulin infusion system
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Diabetes & Endocrinology, P.A.
Inflammatory Arthritis, Diabetes (DM)
Validation of Hemoglobin A1c in Patients With Inflammatory Arthritis Treated With Sulfasalazine
The purpose of this study is to examine whether the blood test Hemoglobin A1c (HbA1c) gives an accurate picture of blood glucose levels in patients with inflammatory arthritis who are treated with sulfasalazine.
- Conditions
- Inflammatory Arthritis, Diabetes (DM), Rheumatoid Arthritis (RA), Type 1 Diabetes Mellitus
- Trial name
- DIA2SULFA (NCT07416656)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Klavs Würgler Hansen
Type 1 Diabetes, Dawn Phenomenon
Comparison of Lantus and Neutral Protamine Hagedorn (NPH) Insulin in the Dawn Phenomenon
1. To investigate the effect of insulin glargine (Lantus™) vs NPH insulin regarding glycemic control during the early AM (dawn phenomenon) in individuals with type 1 diabetes. 2.
- Trial name
- DAWN (NCT00694122)
- Testing
- Lantus (glargine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
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