Clinical trials: Diabetes Mellitus, Type I
Diabetes Mellitus, Type 1
Improving Control and Reducing the Risk of Hypoglycemic Episodes in Type 1 Diabetes
The purpose of this study is to test two newly developed computer programs, Integrated Biobehavioral Monitoring and Feedback (IBMF) IBMF-1 and IBMF-2. The computer programs are considered experimental.
- Trial name
- BPK002 (NCT00315939)
- Testing
- Integrated Biobehavioral Monitoring & Feedback - 1 (IBMF-1), Integrated Biobehavioral Monitoring & Feedback - 2 (IBMF-2)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boris Kovatchev, PhD
Diabetes Mellitus, Type 1
Effectiveness of a Combined mHealth-CBT Psychological Intervention to Improve Psychological Well-Being in Young Patients With T1D
Type 1 diabetes (T1D) can lead to psychological adjustments that impact the acceptance and management of this health condition, as well as the overall quality of life of patients, especially among the young.
- Trial name
- NCT06450730
- Testing
- Cognitive-Behavioral Therapy: face-to-face + app
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Type 1 Diabetes Mellitus, Continuous Glucose Monitor
Web-Based Intervention Designed to Educate and Improve Adherence Through Learning to Use Continuous Glucose Monitoring
The goal of this pilot study is to produce a high-quality, theory-driven, therapeutic, web-based intervention that provides extended training and peer support to adolescents and young adults with type 1 diabetes who are newly…
- Trial name
- IDEAL CGM (NCT03367351)
- Testing
- Web-Based Education, Social Support, Standard of Care
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Type 1 Diabetes
Two Way Crossover Closed Loop MPC vs Control IQ
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a missed meal bolus detection algorithm for use within an AP control system.
- Trial name
- NCT05799781
- Testing
- MPC closed-loop system, t:slim X2 pump with Dexcom G6 CGM and Control IQ
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes, Hypoglycemia Associated Autonomic Failure
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles.
- Trial name
- NCT01672255
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 1
Omega-3 Fatty Acids Supplementation Improves Early-stage Diabetic Nephropathy and Subclinical Atherosclerosis in Pediatric Patients With Type 1 Diabetes
The investigators conducted this randomized-controlled trial to assess the effect of oral omega-3 supplementation on glycemic control, lipid profile, albuminuria level, kidney injury molecule-1 (KIM-1) and carotid intima media…
- Trial name
- NCT05980026
- Testing
- oral omega-3 fatty acids supplementation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
Insulet Artificial Pancreas Evaluating Meal Performance and Moderate Exercise (IDE2)
To assess the safety and performance of the Insulet AP (artificial pancreas) system, using the Omnipod® insulin management system, Dexcom G4 Share® AP System and personalized model predictive control algorithm in adults with type…
- Trial name
- IDE2 (NCT03064906)
- Testing
- Insulet AP (artificial pancreas) System
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Insulet Corporation
Type 1 Diabetes
A Euglycemic Insulin Clamp Study in Type 1 Diabetic Patients With Oral Insulin (ORAMED)
ORAMED has developed an oral insulin that, in preliminary studies, has shown promise. In the present study investigators will perform a pharmacodynamic/pharmacokinetic study to evaluate this novel insulin preparation as a…
- Trial name
- NCT02535715
- Testing
- ORMD-0801 capsules- 2x8mg, ORMD-0801 capsules- 3x8mg, ORMD-0801 capsules- 1x16mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Metabolic Integrity
Effects of Intensive Bolus Intravenous Insulin Delivery on Metabolic Integrity in Type 1 and Type 2 Diabetes
The purpose of this study is to determine if restoring normal metabolic function in patients with type 1 or type 2 diabetes can improve the impact of the consequences of diabetic complications on the overall health and quality of…
- Trial name
- NCT01023165
- Testing
- Humulin, Humalog, Novolog
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Global Infusion and Aspiration Systems, LLC
Type 1 Diabetes Mellitus
Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patients
The transition from the Pediatric clinic to the adult care is a challenging period for young adults with type 1 diabetes, due to the high risk of poor glycemic control.
- Trial name
- METRO (NCT03463564)
- Testing
- Insulin pump, Insulin injections
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
T1DM - Type 1 Diabetes Mellitus
JAK1 Inhibitor Ivarmacitinib for Improving Pancreatic Islet Function in T1D
This is a double-blind, randomized, placebo-parallel-controlled, multicenter study. The objective is to evaluate the efficacy and safety of Ivarmacitinib 8 mg administered for 52 weeks in preserving pancreatic β cell function in…
- Trial name
- INSPIRE-T1D (NCT07845955)
- Testing
- Ivarmacitinib
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Huijie Zhang
Type 2 Diabetes, Nephropathy
A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-insulin Dependent Diabetes (0954-147)(COMPLETED)
Evaluate the effect of Losartan in reducing kidney disease in patients with Non-insulin Dependent Diabetes and Nephropathy (kidney damage that usually accompanies late stage Diabetes Mellitus).
- Trial name
- NCT00308347
- Testing
- MK0954, losartan / Duration of Treatment: mean 3.4 years
- Volunteers
- 1,513 people
- Sponsor
- Organon and Co
Type 1 Diabetes Mellitus, Exercise
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes
Whereas physical activity clearly results in improvements in glycemic control in type 2 diabetes, in individuals with type 1 diabetes (T1DM) the impact of exercise on blood sugar control is more complex.
- Conditions
- Type 1 Diabetes Mellitus, Exercise, Hypoglycemia, Carbohydrate Metabolism
- Trial name
- CARBEX1 (NCT02068638)
- Testing
- IHE first, CONT second, CONT first, IHE second, GLU first, GLU-FRU second
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Type 1
Diabetes Intervention Program for Adolescents With Persistent High HA1c
The purpose of this project is to assess the feasibility and efficacy of a new group therapy program for adolescents with Type 1 diabetes and compromised metabolic control (high A1c).
- Trial name
- NCT02212158
- Testing
- motivational interviewing group
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type1diabetes
4T Sustainability Program
The goal of the 4T program is to implement proven methods and emerging diabetes technology into clinical practice to sustain tight glucose control from the onset of type 1 diabetes (T1D) and optimize patient-reported and…
- Trial name
- NCT06314048
- Testing
- CGM and RPM
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Stanford University
Type1diabetes
Safety of Closed-loop Hybrid Insulin Administration During Ramadan Fasting in People Living With Type 1 Diabetes
Fasting in Ramadan is not recommended for people with type 1 diabetes. The main risk associated with fasting is dysglycemia (hypoglycemia, hyperglycemia, diabetic ketosis) and dehydration.
- Trial name
- RAMDAM (NCT05747352)
- Testing
- closed-loop hybrid insulin administration
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3
It has been found that in some cases, when a person with Diabetes Mellitus has an episode of low blood sugar,or hypoglycemia, and then later exercises, he or she is vulnerable to another bout of hypoglycemia during that exercise.
- Trial name
- NCT00742521
- Testing
- glucose clamp
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Type 1 Diabetes
Coin2Dose: Behavioral Economics to Promote Insulin BOLUS Activity and Improve HbA1c in Teens
Our objective is to test the feasibility, acceptability, and initial efficacy of using behavioral economics incentives (BEI) in a novel, semi-automated intervention to target daily insulin BOLUS scores in adolescents with…
- Trial name
- Coin2Dose (NCT05280184)
- Testing
- Coin2Dose
- Where
- 2 sites in United States
- Volunteers
- 173 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Nerve Conduction Velocity in Diabetic Children
The investigators intend to study children and adolescents from 8 to 18 years suffering from diabetes mellitus type 1 for more than one year.
- Trial name
- NCT01017718
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Landeskrankenhaus Feldkirch
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