Clinical trials: Diabetes Mellitus, Type I
Diabetes Mellitus, Type 1, Carbohydrates
Carbohydrate Estimation Supported by the GoCARB System
The standard method for determining the carbohydrate content of a meal in patients with diabetes mellitus is the weighing of individual foods. However, in daily life, the weighing is not practical at all times.
- Trial name
- NCT02546063
- Testing
- Smartphone App
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Type 1 Diabetes Mellitus
Repeated Dosing Study With a New Insulin Glargine Formulation and Lantus® in Patients With Type 1 Diabetes Mellitus
Primary Objective: To assess the safety and tolerability of two dose levels of a new insulin glargine formulation in a once-daily multiple dosing regimen Secondary Objective: To compare the pharmacokinetic and pharmacodynamic…
- Trial name
- NCT01349855
- Testing
- Insulin glargine HOE901
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Sanofi
Diabetes, Diabetes Mellitus, Type 1
A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in Bangladesh
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control, complications in diabetic subjects in Asia.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- DiabCare Asia (NCT00839878)
- Testing
- No treatment given
- Where
- Bangladesh
- Volunteers
- 2,092 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Type 2 Diabetes
Clinical and Economic Benefits of Cardiovascular Risk Management by a Dietician in Type 2 Diabetes Patients
Worldwide, health systems and practitioners are facing obesity epidemics. High blood pressure, dyslipidemia and diabetes prevalence will explode during the 21st century.
- Trial name
- GRC (NCT00444899)
- Testing
- Intensive treatment, Normal follow-up
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Type 1
Beta Cell Rescue in New Onset Type 1 Diabetes With Efalizumab
In this single-center therapeutic study, we will study the ability of efalizumab to protect remaining beta cells in teenagers and young adults who have been newly diagnosed with type 1 diabetes mellitus.
- Trial name
- BRiTE (NCT00737763)
- Testing
- efalizumab
- Sponsor
- Emory University
Type 1 Diabetes, Dermatologic Complication
Prevention of Skin Problems With Diabetes Devices in Pediatric Patients
A Cluster-controlled Intervention Trial regarding Prevention of Dermatological Complications towards use of Continuous glucose monitoring and insulin pumps in pediatric patients with Type 1 Diabetes.
- Trial name
- NCT04258904
- Testing
- Skin Care Program
- Where
- Denmark
- Volunteers
- 236 people
- Sponsor
- Copenhagen University Hospital at Herlev
Pregnant Women, Diabetes Type 1
Factors Associated With Cesarean Delivery in Women With Type 1 Diabetes
Introduction : Cesarean rate varies from 45% to 73% in the literature in patient with diabetes type 1. Having a prior C-section is the most important risk factor.
- Conditions
- Pregnant Women, Diabetes Type 1, Cesrean Delivery
- Trial name
- NCT03538106
- Where
- France
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus
Insulet Artificial Pancreas Evaluating Meal Performance and Moderate Exercise (IDE2)
To assess the safety and performance of the Insulet AP (artificial pancreas) system, using the Omnipod® insulin management system, Dexcom G4 Share® AP System and personalized model predictive control algorithm in adults with type…
- Trial name
- IDE2 (NCT03064906)
- Testing
- Insulet AP (artificial pancreas) System
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Insulet Corporation
Type 1 Diabetes Mellitus
T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs
The investigational therapy under study in this trial, regulatory T cells (Tregs), offers the hope of stabilizing further destruction of insulin producing beta cells in type 1 diabetes.
- Trial name
- Treg (NCT01210664)
- Testing
- Ex vivo Expanded Human Autologous Polyclonal Regulatory T Cells
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Type 1, Energy Metabolism
Menstrual Cycle Mapping While Using Closed-Loop Insulin Delivery
The hypothesis is that menstrual cyclicity affects glucose and energy metabolism in women with type 1 diabetes. The rationale of the hypothesis on cycle effects builds on the assumption that fluctuations of female sex hormones…
- Trial name
- MCM-Loop (NCT07478211)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Lia Bally
Type 1 Diabetes
Do "sugar Swings" Impact the Brain Function and the Eating Behaviors of People with Type 1 Diabetes
In type 1 diabetes, it is common to choose the food we eat according to the blood sugar level and the insulin dose and vice versa.
- Trial name
- NCT05487534
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Laval University
Oncology, CTLA4 Haploinsufficiency
Safety and Toxicity Study of IMM27M in Patients With Advanced Solid Tumor
This is a single arm, open label, multi-center and fist in human dose escalation study, to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity in patients with advanced and metastatic solid tumor.
- Trial name
- NCT05235438
- Testing
- IMM27M
- Where
- 6 sites in China
- Volunteers
- 16 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Type 1 Diabetes, Quality of Life
Randomized Crossover Study to Test the Impact of Using a Software for Smartphones and Tablets in Treating Type 1 Diabetes
The purpose of this study is to evaluate the impact of a software for smartphones and tablets on type 1 diabetes control and quality of life
- Conditions
- Type 1 Diabetes, Quality of Life, Hypoglycaemia
- Trial name
- NCT02107326
- Testing
- Webdia Software
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Philippe Klee
Type 1 Diabetes
Evaluation of the MiniMed™ 780G System in Type 1 Adult and Pediatric Subjects Utilizing Insulin Fiasp®
This global study (US, Canada, and Australia) will evaluate the safety and effectiveness of the MiniMed 780G system in type 1 adult and pediatric subjects utilizing Fiasp (insulin aspart injection) in a home setting.
- Trial name
- NCT05224258
- Testing
- MiniMed 780G System
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 240 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
A Safety and Tolerability Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus
The purpose of this trial is to test if VC-02™ combination product can be implanted subcutaneously in subjects with Type 1 Diabetes and maintained safely for up to four (4) months.
- Trial name
- NCT03162926
- Testing
- VC-02 Combination Product (aka PEC-Direct)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- ViaCyte
Diabetes Mellitus, Type 1
ECG Changes in Children and Adolescents With Type 1 Diabetes
Diabetes Mellitus type 1 is characterized by an absolute insulin deficiency caused by T-cell-mediated autoimmune destruction of pancreatic β-cells .
- Trial name
- NCT03260998
- Testing
- electrocardiogram
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Foot Ulcer, Diabetic
Use of Procenta® Conformable Barrier for Non-Healing Foot & Ankle Ulcers in Patients With Diabetes Mellitus Types I and II
Procenta® has been successful in facilitating closure of non-healing diabetic ulcers in patients where proper wound care management/practice has failed along with other allo- and xenografts.
- Trial name
- Procenta (NCT05099887)
- Testing
- Procenta conformable barrier
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The VA Western New York Healthcare System
Diabetes (DM), Diabetic Ketoacidosis
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetic ketoacidosis (DKA) is increasingly recognized in adults with "ketone-prone" type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily "stunned" during severe, prolonged high…
- Conditions
- Diabetes (DM), Diabetic Ketoacidosis, Ketosis Prone Diabetes, Hyperglycaemia (Diabetic)
- Trial name
- NCT07167693
- Testing
- Arginine hydrochloride, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David K Carroll
Type 1 Diabetes Mellitus
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
INHALE-1st is a Phase 2, single-arm, multi-center, clinical study evaluating the safety and efficacy of Afrezza in combination with subcutaneously-injected basal insulin (BI) for youth 6 to <18 years old with newly diagnosed…
- Trial name
- INHALE-1st (NCT07224321)
- Testing
- Technosphere Insulin, Basal insulin
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mannkind Corporation
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