Clinical trials: Diabetes Mellitus, Type I
Personalized Medicine in Type 1 Diabetes
Measuring and Predicting Glycemic Response to Food in Patients With Type 1 Diabetes
Personalized medicine methods in the management of type 1 diabetes
- Trial name
- NCT02919839
- Testing
- non-Interventional
- Volunteers
- 200 people
- Sponsor
- Dr. Orit Hamiel
Diabetes Mellitus, Type 1
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)
This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG).
- Trial name
- NCT04387422
- Testing
- Experimental hyperglycemia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Acromegaly, Type 2 Diabetes Mellitus
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
Growth hormone (GH) and Insulin-like growth factor-I (IGF-I) secretion are altered in acromegaly and type 2 Diabetes Mellitis (DM).
- Trial name
- NCT00915954
- Testing
- Oral Glucose Tolerance Test, Subcutaneous administration of recombinant human IGF-1
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Type 1 Diabetes Mellitus
Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin
This is a pilot study to examine and compare the efficacy of supervised injections of long acting insulins degludec and glargine to protect youth with poorly controlled type 1 diabetes (T1D) from development of ketones.
- Trial name
- NCT03400501
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Yale University
Quality of Life
Study of Impact of Art Therapy Sessions Given to Family Caregivers of Children With Type 1 Diabetes
Diagnostic of diabetes in childhood brought modification of family way of life, particularly in child and caregivers lifes. The education patient programs are in France centered on curative competencies of care.
- Trial name
- EDUCARTPED (NCT02797730)
- Testing
- art-therapy sessions
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Type 1 Diabetes
Open-label Investigation of the Safety and Efficacy of DIABECELL in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to establish the efficacy and safety of xenotransplantation of DIABECELL [immunoprotected (alginate-encapsulated) porcine islets] in patients with established type 1 diabetes mellitus
- Trial name
- NCT01736228
- Testing
- DIABECELL
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Living Cell Technologies
Diabetes Mellitus, Type 1
Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes
This study is evaluate the superior efficacy of a Continuous Glucose Monitor (CGM)-based advisory system in Type 1 Diabetes Mellitus (T1DM), as compared to Sensor Augmented Mode (SAM) therapy, and with characterizing the impact…
- Trial name
- DSS-2 (NCT04443153)
- Testing
- Personalized Feedback, Decision Support System, Sensor Augmented Mode
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Text Message for Adolescents With Poorly Controlled Type 1 Diabetes
The purpose of this study is to assess HbA1c reduction after supportive care by SMS among adolescents with poorly controlled type 1 diabetes.
- Trial name
- DIABETO-SMS (NCT02230137)
- Testing
- Text message arm
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes, Hypoglycemia
Insulin Management for Exercise in Patients With Type 1 Diabetes
The purpose of this study is to compare the time spent in glucose target range (4.0-10.0 mmol/L) during exercise and in recovery using three different basal insulin management strategies for prolonged aerobic exercise: A) pump…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Physical Activity
- Trial name
- NCT03130101
- Testing
- Change in their basal insulin rate
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- York University
Type 1 Diabetes, Obesity
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
The main purpose of this study is to find out how well and how safely tirzepatide works long-term in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 20 months.
- Conditions
- Type 1 Diabetes, Obesity, Overweight
- Trial name
- SURPASS-T1D-2 (NCT06962280)
- Testing
- Tirzepatide
- Where
- 79 sites in United States, Argentina and 8 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitis, Cognition
Glycemic Control, Brain Structure and Cognition in Youth With Type 1 Diabetes (T1DM)
LO5 study: The investigators are inviting a new group of youth (ages 7-16) who have been recently diagnosed with type 1 diabetes and their non-diabetic siblings.
- Trial name
- LO5/HY5 (NCT00879203)
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infections, AIDS
Safety Study of Maraviroc's Effect on Human Osteoclasts
This study is to investigate the safety of maraviroc by examining whether there is bone metabolism dysfunction in actual use of maraviroc in human body, or not, measuring bone mineral density and markers for bone formation…
- Trial name
- MVC-Bone (NCT01428986)
- Testing
- Maraviroc
- Where
- Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Center for Global Health and Medicine, Japan
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes
EMPoWER Study - Strengths-based Behavioral Intervention for Youth With Type 1 Diabetes
The EMPoWER Study randomized clinical trial is a strengths-based behavioral intervention delivered to youth with type 1 diabetes (age 10 to 13) and their parents.
- Trial name
- EMPoWER (NCT06014879)
- Testing
- Type 1 Doing Well (T1DW) Program, Diabetes-Related Information and Resources Program
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Baylor College of Medicine
Evidence of Liver Transplantation
Autologous Transplantation of Mesenchymal Stem Cells for Treatment of Patients With Onset of Type 1 Diabetes
Type 1 diabetes mellitus (T1DM)is characterized by the autoimmune destruction of the pancreatic β cells; as a result, patients with T1DM are dependent on exogenous insulin to control their blood glucose continuously.
- Trial name
- NCT01157403
- Testing
- Autologous transplantation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lu Debin
Diabetes Mellitus, Type 1
Individualized Automatic Target Coaching Message for Glycemic Management and Depressive Symptom
This is a single-center, randomized, prospective, feasibility and acceptability trial in patients with type 1 diabetes. For six weeks, the intervention group will receive weekly personalized coaching messages for glycemic…
- Trial name
- NCT06525454
- Testing
- Personalized coaching messages for blood glucose and emotions
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- Samsung Medical Center
Type 1 Diabetes
Open-Label Extension Study to Evaluate Long Term Safety and Treatment Effect of DiaPep277®
This is an extension study to evaluate the safety and tolerability of long-term treatment with DiaPep277® and to determine the long-term treatment effect of DiaPep277® on parameters of metabolic control and on preservation of…
- Trial name
- DIA-AID 2 (NCT01898286)
- Testing
- DiaPep277®
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Andromeda Biotech Ltd.
Type 1 Diabetes Mellitus
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
The biggest challenges for glycemic control during the day time involve meals and exercise variations, which are impacted by age, fitness level, duration, intensity and history of exercise.
- Trial name
- NCT02604524
- Testing
- Closed-Loop Control, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Daniel Chernavvsky, MD, CRC
Type 1 Diabetes Mellitus
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus on Basal Plus Mealtime Insulin
Primary Objective: To compare the glucose control during treatment with a new formulation of insulin glargine and Lantus in adult participants with type 1 diabetes mellitus Secondary Objectives: To compare a new formulation of…
- Trial name
- NCT01658579
- Testing
- HOE901-U300 (new formulation of insulin glargine), Lantus (insulin glargine)
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus, Subclinical Inflammation
AI(I)DA Acarbose and the Subclinical Inflammation
Acarbose an alphaglucosidase inhibitor changes in a complex way the transport, the digestion and the place of glucose release and absorption.
- Trial name
- NCT00558883
- Testing
- acarbose
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- GWT-TUD GmbH
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