Clinical trials: Diabetes Mellitus Complication
Diabetic Angiopathies, Diabetes Mellitus, Type 2
Assessment of Metabolic Profiles of Lower Extremity Arterial Disease in Patiens Withe Type 2 Diabetes
The prevalence of lower extremity arterial disease (LEAD) in patients with diabetes increases significantly and are characterized with obvious arteriosclerosis that are caused by multiple metabolic disorders.
- Trial name
- NCT05068895
- Testing
- liquid chromatography-mass spectrometry
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu
Gestational Diabetes
Therapeutic Synergy of Probiotic Augmented Conventional Antidiabetic Pharmacotherapy in Gestational Diabetes Mellitus
1. To compare the effects of metformin, insulin, and their combination with multistrain probiotics on glycemic control and insulin resistance in women with gestational diabetes mellitus (GDM), assessed by FPG, HbA1c, fasting…
- Trial name
- NCT07645001
- Testing
- GRP 1 Tab metformin, GRP 2 Inj insulin, GRP 3 Tab metformin + HI flora sachet
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Riphah International University
Diabetic Retinopathy
A Study on Traditional Chinese Medicine (TCM) Comprehensive Protocol of Prevention and Control in Diabetic Retinopathy
1. Title: A Study on TCM comprehensive protocol of Prevention and Control in Diabetic Retinopathy. 2. Objectives of study: To evaluate the Intervention effect of integrate control protocol on reducing the incidence rate of…
- Trial name
- NCT00904592
- Testing
- Qi ming granula
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Diabetic Retinopathy
Effect of Intravitreal Bevacizumab on Early Post-Vitrectomy Hemorrhage in Diabetic Patients
The purpose of this study is to determine whether bevacizumab 1-2 weeks before vitrectomy is effective in lowering the rate of early post-vitrectomy vitreous hemorrhage in diabetic patients.
- Trial name
- NCT00524875
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Postherpetic Neuralgia, Diabetic Polyneuropathies
Botulinum Toxin in Peripheral Neuropathic Pain
Pain due to peripheral nerve lesion remains extremely difficult to treat and current treatments have onl moderate efficacy and/or side effects.
- Conditions
- Postherpetic Neuralgia, Diabetic Polyneuropathies, Other Polyneuropathies
- Trial name
- NCT01251211
- Testing
- botulinum toxin type A
- Where
- 3 sites in Brazil, France
- Volunteers
- 66 people
- Sponsor
- Hospital Ambroise Paré Paris
Gestational Diabetes, Cardiovascular Risk Factors
Autonomic Nervous System and Exercise In Gestational Diabetes
The focus of this study is on individualized exercise prescription on primary prevention of cardiovascular diseases (CVD). Special attention is set on autonomic nervous system function and inflammation.
- Trial name
- ANS-EXE (NCT01675271)
- Testing
- individual exercise, general exercise
- Where
- Finland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Diabetic Foot Ulcer
Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers
Diabetic foot ulcers (DFU) develop because of the interaction of predisposing factors like neuropathy, angiopathy and infection. Likewise, environmental factors like lesion hygiene, diet and life style.
- Trial name
- NCT02632877
- Testing
- Pirfenidone with MODD, Ketanserin
- Where
- 2 sites in Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Type 1 Diabetes
Obesity Treatment to Improve Diabetes
As the obesity pandemic continues unabated, one can expect to see an increase in the prevalence of TID/T2D and associated CKD. As a result, death will rise, preceded by an increase in kidney failure, requiring dialysis and renal…
- Trial name
- OTID (NCT05390307)
- Testing
- Liraglutide / Semaglutide, Dapagliflozin, Liraglutide or Semaglutide / Dapagliflozin
- Where
- Kuwait
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Diabetic Foot, Stem Cell
Stem Cell Derived Exome for Treatment of Diabetic Foot
This trial is designed to investigate the safety and efficacy of patients with diabetic foot by using stem cell derived exome.
- Trial name
- NCT06480123
- Testing
- Skin drug prepared with exome originated from stem cell
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Diabetic Foot Ulcer
A Follow-up Study to Evaluate the Safety of ALLO-ASC-DFU in ALLO-ASC-DFU-301 Clinical Trial
This is a follow-up study to evaluate the safety for the subjects with ALLO-ASC-DFU treatment in phase 3 clinical trial (ALLO-ASC-DFU-301) for 24 months
- Trial name
- NCT04590703
- Testing
- ALLO-ASC-DFU, Vehicle sheet
- Where
- 8 sites in South Korea
- Volunteers
- 73 people
- Sponsor
- Anterogen Co., Ltd.
Gestational Diabetes Mellitus
Glycemic Objectives of Women With Gestational Diabetes Mellitus
In a previous study, the investigators established the dosage of foetal glycated hemoglobin (FGH). It represents the mean of blood sugar 4-6 before the delivery.
- Trial name
- NCT02478762
- Testing
- Normal glycemic control, Low glycemic control
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Université de Sherbrooke
Diabetic Complication
Genetic Testing and Counseling to Reduce Diabetic Complications
The risk of diabetic kidney complications includes non-modifiable risk factors such as genetic predictors, as well as modifiable risk factors such as hyperglycaemia, hypertension, hyperlipidaemia and proteinuria.
- Trial name
- NCT02364323
- Testing
- Personalized Risk Counselling, Normal usual care
- Where
- Hong Kong
- Volunteers
- 435 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus
A Study to Assess Efficacy and Safety of ASP1941 in Diabetic Patients With Renal Impairment
This study is to assess the effect of renal function on the efficacy and safety of ASP1941 in type 2 diabetic patients with mild to moderate renal impairment.
- Trial name
- NCT01316094
- Testing
- ASP1941
- Where
- 8 sites in Japan
- Volunteers
- 165 people
- Sponsor
- Astellas Pharma Inc
Diabetes Mellitus, Chronic Kidney Disease
Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced nephropathy (CIN).
- Trial name
- NCT02808351
- Testing
- Berberine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type2 Diabetes, Complication of Bariatric Procedure
Efficacy and Safety of One-anastomosis Versus Roux-en-Y Gastric Bypass for Type 2 Diabetes Remission
Diabetes mellitus (T2DM) is the most common complication of obesity patients. According to previous literature reports, weight loss and metabolic surgery are powerful means to treat obesity complicated with T2DM.
- Trial name
- ORDER (NCT05015283)
- Testing
- The laparoscopic One-anastomosis gastric bypass will consist of:, The laparoscopic Roux-en-Y gastric bypass will consist of:
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Beijing Friendship Hospital
Obesity, Pregnancy
Determination of Maternal and Neonatal Apelinemia in Obese Women During Pregnancy
Background : Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation.
- Conditions
- Obesity, Pregnancy, Gestational Diabetes
- Trial name
- OB-APE (NCT02796456)
- Testing
- blood sample
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Lille
Diabetes, Myocardial Infarction
Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment
The purpose of this study is to determine whether Vitamin E treatment to Diabetic patients, who carry the Haptoglobin 2-2 Phenotype, prevents cardiovascular complications such as acute MI and Stroke.
- Conditions
- Diabetes, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT00220831
- Testing
- Natural source Vitamin E 400IU/day
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Technion, Israel Institute of Technology
Chronic Kidney Disease, Type 1 Diabetes Mellitus
A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes
Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly, and type 1 diabetes.
- Trial name
- FINE-ONE (NCT05901831)
- Testing
- Finerenone
- Where
- 79 sites in United States, Canada and 7 more
- Volunteers
- 242 people
- Sponsor
- Bayer
Diabetic Foot Ulcer
Intensive Glycemic Control For Diabetic Foot Ulcer Healing
With the available molecular and cellular evidence of impaired wound healing due to hyperglycemia, investigators postulate hypothesis asking whether intensive glycemic control could improve diabetic foot ulcer healing rates.
- Trial name
- INGLOBE (NCT04323462)
- Testing
- Insulin Glargine, Diabetic DM
- Where
- 2 sites in India
- Volunteers
- 326 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diabetic Nephropathies
Effect of High Intensity Interval Versus Moderate Intensity Continuous Training on Microalbuminurea
purpose: to investigate the effect of low-volume high-intensity interval training and moderate- intensity continuous training on microalbuminuria in patients with diabetic nephropathy.
- Trial name
- NCT06616805
- Testing
- treadmill
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University