Clinical trials: Diabetes Mellitus Non-insulin-dependent
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Obstructive Sleep Apnea, Diabetes Mellitus
Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea
The investigators plan to recruit 140 patients (35 subjects in each group) over a period of 18 months in a prospective study of matched/paired case-control subjects across the four groups to measure the 5-year risk of developing…
- Trial name
- OSA & DM (NCT01447251)
- Testing
- PreDx Diabetes Risk Score
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Obesity and Obesity-related Medical Conditions
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
This study is designed to test how well the combination of MET233 with MET097 works to treat individuals with obesity or overweight with or without diabetes.
- Trial name
- NCT06924320
- Testing
- MET233 and MET097, MET097
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance
Efficacy and Safety of Sanggua Tablets in the Treatment of Patients With Impaired Glucose Tolerance and Mild Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) are growing public health challenges. Early intervention in mild T2DM and IGT is essential to prevent disease progression and severe complications.
- Trial name
- NCT06964620
- Testing
- Sanggua tablets
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Tongji Hospital
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Effects of Henagliflozin on the Brain Function in T2DM Patients With Mild Cognitive Impairment: a Randomized, Parallel Controlled Clinical Trial
This is a prospective, randomized, open label, parallel, 16-week study to explore and evaluate the therapeutic effects of Henagliflozin on the cognitive function, olfactory function, and odor-induced brain activation in T2DM…
- Trial name
- NCT06085703
- Testing
- Henagliflozin, Gliclazide
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetes, Diabetes Mellitus, Type 2
Comparison of Insulin Detemir Versus Insulin NPH on Weight Change in Overweight and Obese With Type 2 Diabetes
This trial is conducted in Europe. The purpose of the trial is to investigate the effect of insulin detemir on weight change in overweight and obese patients with type 2 diabetes.
- Trial name
- PREDICTIVE™ (NCT00504673)
- Testing
- insulin detemir, insulin NPH, insulin aspart
- Where
- Spain
- Volunteers
- 277 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Non-Insulin-Dependent
Safety and Efficacy of INGAP-Peptide in Patients With Type 2 Diabetes
Insulin is a chemical that the body needs in order to use or store sugar. It is made by a type of cell called a beta cell which resides in an organ known as the pancreas.
- Trial name
- NCT00071422
- Testing
- INGAP-Peptide
- Where
- 17 sites in United States
- Volunteers
- 126 people
- Sponsor
- Exsulin Corporation
Type 2 Diabetes
Virtual World Health Behavior Counseling for Patients With Diabetes
Comparison of 2 methods of delivery health education for African-American women with Type 2 Diabetes. The two methods are: face to face education in small groups, as compared to delivering the same curriculum in the virtual…
- Trial name
- NCT01340079
- Testing
- virtual world, face to face
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Boston Medical Center
Diabetes Type 1, Diabetes Mellitus, Type 2
Antenatal Hand Milking for Pregnant Women With Diabetes'
The project is a descriptive cohort study with a retrospective and a prospective group where pregnancy and childbirth data will be studied.
- Conditions
- Diabetes Type 1, Diabetes Mellitus, Type 2, GDM
- Trial name
- NCT04794283
- Testing
- Breast milk
- Where
- Sweden
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetes Type 2
Evaluation of a Closed-loop Insulin Delivery System at Home With Tailored Home Care Services in Poorly Controlled Type 2 Diabetes Patients (T2D)
Closed-loop insulin delivery system has the potential to improve the condition of many poorly controlled insulin-treated Type 2 Diabetes (T2D) patients.
- Trial name
- CLOSEAP+ (NCT04233229)
- Testing
- t:slim X2 with Control-IQ, home healthcare services, usual care for daily insulin treatment
- Where
- 10 sites in France
- Volunteers
- 43 people
- Sponsor
- Air Liquide Santé International
Type 2 Diabetes Mellitus
GLP-1 and Non-exercise Activity Thermogenesis in RHZ
Rationale: Treatment with glucagon-like peptide 1 (GLP-1) has been shown to reduce plasma glucose levels to a further extent when added to standard therapy in type 2 diabetes mellitus.
- Trial name
- NCT01638260
- Testing
- Liraglutide, NEAT
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
People of black African and Caribbean descent have a greater risk of developing type 2 diabetes than white Europeans. The aim of this study is to increase our knowledge of how the condition may arise, and what underlies this…
- Trial name
- NCT03864562
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Overweight, Obesity
Mitochondrial Methylation in Type 2 Diabetes
The overarching goal of this proposal is to determine whether DNA methylation of the mitochondrial DNA impairs mitochondrial function in insulin resistant states such as overweight/obesity and type 2 diabetes.
- Conditions
- Overweight, Obesity, Diabetes Mellitus, Type 2, Insulin Resistance
- Trial name
- NCT04126551
- Testing
- Methylation status
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Metabolic Syndrome X, Type 2 Diabetes Mellitus
Effect of Fish Oil on Insulin Sensitivity
The purpose of this study is to determine whether a prolonged (9 month) high (6g/d) of marine oil improves insulin sensitivity and glucose control in subjects with impaired glucose regulation.
- Conditions
- Metabolic Syndrome X, Type 2 Diabetes Mellitus, Sarcopenia
- Trial name
- NCT01241474
- Testing
- EPAX 6000 (marine omega 3 EPA/DHA fatty acid concentrates, Maize (corn) oil
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Aberdeen
Obesity, Diabetes Mellitus
Type 2 Diabetes Primary Prevention for At Risk Girls
Purpose: To evaluate two approaches to prevent obesity and type 2 diabetes in young girls. The Need: We are experiencing an epidemic of childhood obesity.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- NCT00063674
- Testing
- Nutrition Education, After-school dance class
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 2
Representation of Diet in the Management of Type 2 Diabetes in Migrant Patients at CHSD
This observational and monocentric study aims to explore how migrant patients with type 2 diabetes perceive and represent food in the context of their diabetes care.
- Trial name
- NCT06969391
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Type 2 Diabetes
Placebo and Active Comparator Controlled Dose Response Study of Rivoglitazone in Type 2 Diabetes
The purpose of the study is to assess the efficacy response of rivoglitazone HCl compared to pioglitazone HCl on the placebo-corrected change from baseline in HbA1c after 12 weeks of treatment in patients with type 2 diabetes.
- Trial name
- RAISE (NCT00575874)
- Testing
- Rivoglitazone HCl, pioglitazone HCl
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Hypertension, Diabete Type 2
Clinical Trial to Evaluate the Efficacy and Safety of Monotherapy Group of HL1113R1 or HL1113R2 Versus HL1113 (Fixed Dose Combination) in Patients With Essential Hypertension and Type II Diabetes Mellitus
This clinical trial is a randomized, active controlled, double blind, parallel, multi center, phase 3 study to evaluate the efficacy and safety of monotherapy group of HL1113R1 or HL1113R2 versus HL1113 (Fixed dose combination)…
- Trial name
- NCT07552389
- Testing
- Test group, Exploratory test group, Control group 1
- Where
- South Korea
- Volunteers
- 228 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Type 2 Diabetes
Attitudes and Unmet Needs Among Type 2 Diabetes Patients
The main purpose of this study is to explore experiences and understand the unmet needs of people with Type 2 Diabetes (T2D) among those who are being managed with basal insulin and those who are insulin naïve in order to…
- Trial name
- NCT05737810
- Testing
- No treatment given
- Where
- 7 sites in Australia, France and 5 more
- Volunteers
- 700 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients
The purpose of this study is to determine whether a new-brand of repaglinide is effective in the treatment of type 2 diabetes patients.
- Trial name
- NCT00336310
- Testing
- Repaglinide
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng-Kung University Hospital
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