Clinical trials: Diabetes Mellitus Risk
Type II Diabetes Mellitus
Feasibility Trial in Urban Pakistan for Community Engagement in Preventing Type II Diabetes and Risk Factors
This project aims to adapt, implement, and evaluate PLA based intervention in urban Karachi, Pakistan for TIIDM prevention and control.
- Trial name
- EMPOWER-D (NCT06570057)
- Testing
- Participatory, learning and Action (PLA) Based intervention
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baqai Institute of Diabetology and Endocrinology
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Type 2 Diabetes Mellitus, Endothelial Dysfunction
Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk
This clinical trial evaluates whether Huangqi Gegen Decoction can improve blood vessel function in adults with type 2 diabetes mellitus who are at very high risk of atherosclerotic cardiovascular disease and meet the traditional…
- Conditions
- Type 2 Diabetes Mellitus, Endothelial Dysfunction, Cardiovascular Risk
- Trial name
- NCT07775664
- Testing
- Huangqi Gegen Decoction Granules, Conventional Treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Putuo Hospital, Shanghai University of Traditional Chinese Medicine
PreDiabetes
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
One in three American adults have prediabetes, and up to 70% of adults with prediabetes eventually develop type 2 diabetes. With the high cost of treating diabetes, cost-effective approaches are needed to reduce the incidence of…
- Trial name
- NCT03504683
- Testing
- Early TRE, Mid-day TRE, Control Schedule
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease)
Lung Cancer Risk in Type 2 Diabetes With COPD: SGLT2 Inhibitors vs. Sulfonylureas
The goal of this observational study is to learn if a specific diabetes medicine can lower the risk of lung cancer in people with type 2 diabetes and chronic obstructive pulmonary disease (COPD).
- Conditions
- Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis)
- Trial name
- NCT07332156
- Testing
- SGLT2 inhibitor, Sulfonylureas (SU), DPP4 inhibitors
- Volunteers
- 21,692 people
- Sponsor
- Samsung Medical Center
Diabetes Risk, CVD Risk
Effectiveness of a Self-health Assessment Mobile Application in Young-to-midlife Adults in Hong Kong
This project aims to compare the effectiveness of Wellnuts, an evidence-based, algorithm-driven self-health assessment mobile application, in empowering asymptomatic young-to-midlife adults in Hong Kong, promoting health…
- Conditions
- Diabetes Risk, CVD Risk, Colorectal Cancer, Lung Cancer
- Trial name
- NCT07720245
- Testing
- Wellnuts app intervention, Web-based health resources
- Where
- Hong Kong
- Volunteers
- 574 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Diabetic Foot, Amputation
Predictors of Foot Amputation in Diabetic Foot Ulcers
Diabetes affects 463 million population of the world. Diabetic foot is one of the complications of uncontrolled diabetes which can lead to amputation in 5- 24% of non-healing diabetic foot ulcers.
- Conditions
- Diabetic Foot, Amputation, Antibiotic Resistant Strain, Diabetic Foot Ulcer
- Trial name
- NCT05551988
- Testing
- Retrospective observational study of diabetic foot ulcer
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Bolan Medical Complex Hospital Quetta Pakistan
Diabetes Mellitus, Type 1
At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension)
This study was an extension of the NIH-sponsored At-Risk (TN-10) type 1 diabetes study (NCT 01030861). Teplizumab-treated and placebo-treated participants in the NIH trial who developed clinical type 1 diabetes after the…
- Trial name
- NCT04270942
- Testing
- teplizumab 1 mg/mL
- Where
- 8 sites in United States
- Volunteers
- 6 people
- Sponsor
- Provention Bio, a Sanofi Company
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
This program will provide patients with type 1 and high risk type 2 diabetes the safest hospitalization by using wireless continuous glucose monitoring devices (CGM) to track their glucose parameters in real-time similar to other…
- Trial name
- CGM (NCT03068273)
- Testing
- Real-time CGM data
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Scripps Whittier Diabetes Institute
Healthy Volunteers, Insulin Resistance
Polyphenols and Insulin Resistance
Diet and nutrition play an essential role in the development and the clinical expression of the most common health problems. Overeating and obesity induce oxidative stress, which has been proposed to be a pathogenic mechanism…
- Conditions
- Healthy Volunteers, Insulin Resistance, Type 2 Diabetes (T2D)
- Trial name
- POLYOXRESIST (NCT01478841)
- Testing
- polyphenol
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Diabetes, Metabolic Diseases
The Fasting II Study
This study will determine whether an intensive fasting protocol alters hemoglobin A1c measurements or other markers of metabolic and cardiovascular risk by performing a 5-week clinical trial of fasting among 12 pre-diabetic…
- Trial name
- NCT01792986
- Testing
- water-only 24-hour fasting once per week for 6 weeks
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Intermountain Health Care, Inc.
Insulin Sensitivity, Type 2 Diabetes
Effect of Diacylglycerol Oil on Risk Factors of Type 2 Diabetes and Complicating Disease, and Mechanism
Diacylglycerol oil has been shown to lower postprandial and fasting serum triacylglycerol levels and reduce body fat. The investigators hypothesize that replacing dietary fat with diacylglycerol oil reduces excess body fat in…
- Conditions
- Insulin Sensitivity, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- NCT01802541
- Testing
- diacylglycerol oil, triacylglycerol oil
- Volunteers
- 127 people
- Sponsor
- Zhejiang University
Type 2 Diabetes, Dietary Intervention
Effects of Combining Cocoa and Soy in Type 2 Diabetes
Diabetes is an increasingly common condition affecting millions of people world wide. The cornerstone of treatment is lifestyle that includes looking at the way how people eat.
- Trial name
- NCT01754662
- Testing
- Soy protein, Isoflavones, Cocoa
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Type 2 Diabetes
Multifactorial Intervention in Type 2 Diabetes - Italy
Despite several clinical trials have clearly demonstrated that the correction of a single cardiovascular risk factor in patients with type 2 diabetes decreases the incidence of myocardial infarction and other cardiovascular…
- Trial name
- MINDIT (NCT01240070)
- Testing
- Intensive care
- Where
- 9 sites in Italy
- Volunteers
- 1,461 people
- Sponsor
- University of Parma
Type 2 Diabetes Mellitus
Diabetes in Europe - Prevention Using Lifestyle, Physical Activity and Nutritional Intervention in Catalonia
Public health strategy on type2 diabetes prevention in primary health care. European coordinated project (DE-PLAN) adapted to Catalonia (DE-PLAN-CAT).
- Trial name
- DE-PLAN-CAT (NCT01519505)
- Testing
- Lifestyle intervention
- Where
- Spain
- Volunteers
- 2,082 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Diet, Cooking
Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease
Background: The risk of heart disease among African Americans is still common despite a greater understanding of the disease and better approaches to managing it.
- Trial name
- NCT04305431
- Testing
- Cooking Intervention
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Diabetes Mellitus, Type 2, Cardiovascular Diseases
A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
The primary purpose of study is to estimate the incidence and comparative effect on health outcomes: 1) hospitalization for heart failure, 2) below knee lower extremity amputation.
- Trial name
- NCT03492580
- Testing
- Canagliflozin, Empagliflozin, Dapagliflozin
- Where
- United States
- Volunteers
- 714,582 people
- Sponsor
- Janssen Research & Development, LLC
Prediabetic State, Dysglycemia
Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to investigate the effects of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day, on cardiometabolic health and gut microbiota profile in overweight-obese…
- Conditions
- Prediabetic State, Dysglycemia, Overweight and Obesity
- Trial name
- NCT05369585
- Testing
- TOTUM-63
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
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