Clinical trials: Diabetes Mellitus Risk
Diabetes Mellitus, Type 1
Biobehavioral Mechanisms of Glucose Variability
The purpose of this study is to investigate how blood sugar changes in response to insulin and what the body does to counter-act low blood sugar in people with Type 1 Diabetes Mellitus.
- Trial name
- NCT01835964
- Testing
- Glucose Variability Observation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
Incretin-based Drugs and Pancreatic Cancer
The purpose of this study is to determine whether incretin-based drugs (used to treat type 2 diabetes) taken either alone in or combination with other anti-diabetic drugs are associated with an increased risk of pancreatic cancer…
- Trial name
- NCT02475499
- Testing
- DPP-4 inhibitors, GLP-1 analogs, Sulfonylureas
- Where
- Canada
- Volunteers
- 886,172 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Atherosclerosis, Cardiovascular Diseases
Non-Traditional Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - Ancillary to VA Study of Glycemic Control
To test whether novel cardiovascular risk factors are related to the presence and development of atherosclerosis and macrovascular events in Type 2 diabetes mellitus and to determine whether intensive glucose lowering therapy…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00021944
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer, Bladder Cancer
Cancer in Patients on Dapagliflozin and Other Antidiabetic Treatment
The primary objectives of this study are (1) to compare the incidence of breast cancer, by insulin use at cohort entry, among females with type 2 diabetes who are new users of dapagliflozin and females who are new users of…
- Trial name
- NCT02695121
- Where
- 4 sites in United States, Netherlands and 1 more
- Volunteers
- 2,133,575 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)
The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to…
- Trial name
- NCT01897532
- Testing
- Linagliptin
- Where
- 649 sites in United States, Argentina and 25 more
- Volunteers
- 6,991 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus, Type 2
Glucose Homeostasis and Incretin Effect T2DM in the Youth- a Study of the Malaysian Population
Early onset type 2 diabetes mellitus among adolescents/youth (YT2DM) is a rising phenomenon. The pathophysiology has been studied primarily on non-Asian populations while literature on incretin effect is scarce.
- Trial name
- NCT02845557
- Testing
- OGTT and IVGTT tests
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RCSI & UCD Malaysia Campus
Cardiovascular Risk, Chronic Kidney Disease
A Research Study Looking at Kidney and Heart Health in Adults With Type 2 Diabetes and Chronic Kidney Disease Treated With Semaglutide in China
The purpose of this clinical study is to find out what happens to kidney and heart health during treatment with a medicine called semaglutide, which is given as an injection under the skin.
- Trial name
- NCT07900438
- Testing
- Semaglutide
- Where
- 26 sites in China
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Obesity
Weight Loss and Reversing T2D Through eHealth Coaching
Background: Systematic reviews conclude that Internet and mobile interventions can significantly change lifestyle in a short time span.
- Trial name
- LIVA (NCT03788915)
- Testing
- Online dietetic lifestyle counseling, Usual care
- Where
- 2 sites in Denmark
- Volunteers
- 340 people
- Sponsor
- University of Southern Denmark
Left Ventricular Dysfunction, Myocardial Infarction
St. Vincent's Screening To Prevent Heart Failure Study
The STOP-HF study is a prospective, randomized, controlled trial recruiting asymptomatic individuals with risk factors for left ventricular dysfunction from 50 primary care clinics in Dublin and south east Ireland.
- Conditions
- Left Ventricular Dysfunction, Myocardial Infarction, Hypertension, Diabetes
- Trial name
- STOP-HF (NCT00921960)
- Testing
- Intervention Care
- Where
- Ireland
- Volunteers
- 1,378 people
- Sponsor
- St Vincent's University Hospital, Ireland
Reducing the Elevated Blood Pressure for Diabetic Hypertensive Patients
Metformin Versus Vildagliptin for Diabetic Hypertensive Patients
This is a controlled study to measure the efficacy of using metformin or vildagliptin for type 2 diabetic patients who suffers from hypertension to reduce cardiovascular risk resulting from both diabetes and hypertension using…
- Trial name
- NCT03253562
- Testing
- Metformin Pill, Vildagliptin 50 mg
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MTI University
Type 2 Diabetes, Obesity
Pilot Sugar Reduction Intervention in Kiritimati Teenagers
Kiritimati is an isolated coral atoll in the Pacific Ocean, and is one of 32 islands that comprise the Republic of Kiribati. Obesity and type 2 diabetes rates are high in Kiribati, but the causes and rates of childhood…
- Trial name
- NCT04319003
- Testing
- Sugar-reduction intervention
- Where
- 2 sites in United States, Kiribati
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Diabetes
Sensor-based Balance Training in Diabetes: A Virtual Reality Paradigm
Diabetic peripheral neuropathy (DPN) can severely deteriorate balance and gait in patients, thereby increasing risk of fall and injury.
- Trial name
- NCT02214329
- Testing
- Sensor-based exercise training, In-home balance training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Arizona
Severe Complications of Urinary Tract Infections
Complications of UTI in Patients on Dapagliflozin
The objective of this study is to compare, by insulin use at the index date, the sex-specific incidence of hospitalization or emergency department (ED) visit for severe complications of urinary tract infections (UTI), defined as…
- Trial name
- NCT02695173
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 683,380 people
- Sponsor
- AstraZeneca
Type 2 Diabetes
Italian Diabetes and Exercise Study 2
Current guidelines recommend supervised mixed (aerobic+resistance) physical activity to ensure optimal benefits to control blood glucose, lipids, blood pressure, and other cardiovascular risk and to minimize injuries.
- Trial name
- IDES-2 (NCT01600937)
- Testing
- Theoretical & practical exercise counseling
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Metabolic Fitness Association, Italy
Diabetes Type 2
Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes
This study was set up to assess the effects of different doses of aspirin when compared with placebo (dummy drug), used sequentially over a 2 week study period with a 2 week wash-out (rest period) in between, in people with…
- Trial name
- NCT00898950
- Testing
- Aspirin
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Colon Cancer, Lung Cancer
Predictive Genetic Risk Assessment Trial
This proof-of-principle clinical trial at Mayo Clinic studies how patients and their physicians understand and utilize predictive genetic risk assessment.
- Conditions
- Colon Cancer, Lung Cancer, Atrial Fibrillation, Diabetes Type 2
- Trial name
- PGT (NCT00782366)
- Testing
- SNP analysis
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Screening, Hyperlipidemia Screening
Pilot Study Testing Feasibility of Health Screening at Farm Site
Test the feasibility of performing worksite screening of Hypertension, Diabetes and Hyperlipidemia for six months
- Conditions
- Diabetes Screening, Hyperlipidemia Screening, Hypertension Screening
- Trial name
- NCT02418637
- Testing
- Worksite screening for DM, HTN and hyperlipidemia
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Onychomycosis
Laser Therapy for Onychomycosis in Patients Wih Diabetes at Risk for Diabetic Foot Complications
In a sham controlled double-blind trial we aim to establish the efficacy and safety of local application of laser therapy in patients with diabetes with onychomycosis and risk factors for diabetes related foot complications.
- Trial name
- LASER-1 (NCT01996995)
- Testing
- Nd:YAG laser pulse therapy
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Medical Research Foundation, The Netherlands
Diabetes Mellitus, Type 2
Health Coaching, Continuous Glucose Monitoring and AI Mobile App in Diabetes
Lifestyle change is key to diabetes management but there are limited resources and time to support patients in improving lifestyle behaviour in the current healthcare system.
- Trial name
- NCT06028139
- Testing
- Continuous glucose monitoring and health coaching, EMPOWER mobile app
- Where
- 3 sites in Singapore
- Volunteers
- 400 people
- Sponsor
- Singapore General Hospital
Diabetes Mellitus, Type 2, Lifestyle Risk Reduction
Patient-Driven Lifestyle Modification Using FreeStyle Libre in Type 2 Diabetes Patients
We aim to provide medical nutritional therapy to patients with type 2 diabetes who are on oral hypoglycemic agents or on basal insulin only and monitor the glycemic response with flash glucose monitoring or self-monitoring of…
- Trial name
- PDF (NCT04932928)
- Testing
- FreeStyle Libre, Blood glucose meter
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
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