Clinical trials: Diabetes Mellitus Risk
Type-2 Diabetes, Cardiovascular Diseases
Feasibility of a Preventive Program Against Lifestyle Related Diseases
The continuously increasing prevalence of cardiovascular diseases, type-2 diabetes, and COPD is a major health problem in developed countries and is mainly caused by an unhealthy lifestyle.
- Conditions
- Type-2 Diabetes, Cardiovascular Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02797392
- Testing
- Lifestyle intervention
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 9,400 people
- Sponsor
- University of Southern Denmark
Obesity, Metabolic Disease
Behavioral Plant-Based Dietary Intervention in Latinos
The Aims of this study are 1) to develop a traditional plant-based diet that is palatable and acceptable to the Latino population and which contains the appropriate calorie and macronutrient composition needed to lose weight and…
- Trial name
- SB Pilot (NCT05444595)
- Testing
- Behavioral plant-based dietary intervention, Standard care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cardiovascular Disease, Peripheral Artery Disease
Personalized Cardiovascular Risk Information to Initiate and Maintain Health Behavior Changes
The investigators propose an evaluation that will assess three important components of risk communication: 1. provide patients with personalized risk communication using the risk calculator developed by FIMDM and health…
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Ischemic Stroke, Diabetes
- Trial name
- FIMDM_CVD (NCT01134458)
- Testing
- Web-Based Intervention
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Duke University
Gestational Diabetes, Pregnancy, High Risk
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
- Conditions
- Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
- Trial name
- iGDM (NCT05124808)
- Testing
- Intensive glycemic targets, Standard glycemic targets
- Where
- 5 sites in United States
- Volunteers
- 828 people
- Sponsor
- Indiana University
Type 2 Diabetes
Randomized Study of Yohimbine Treatment for Type 2 Diabetes Patients Carrying a Specific Genetic Risk Variant
The investigators have recently discovered a genetic variant in an adrenergic receptor that leads to increased risk for type 2 diabetes.
- Trial name
- YOH1 (NCT01593215)
- Testing
- Yohimbine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Anders Rosengren, MD PhD
Diabetes Mellitus
Substituting Brown Rice For White Rice: Effect On Diabetes Risk Factors In India
Currently, India has the largest absolute number of people with diabetes in the world, and evidence indicates that consumption of whole-grains can decrease diabetes by improving glycemic control.
- Trial name
- NCT01814735
- Testing
- Brown rice, White rice
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Overweight and Obesity, Prediabetes
Effects of Biofunctional Orange Juice on Cardiometabolic Risk Markers
The effects of orange juice enriched with vitamin D3 and encapsulated probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG) compared to conventional orange juice on several cardiometabolic and…
- Conditions
- Overweight and Obesity, Prediabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114576
- Testing
- Orange juice enriched with vitamin D3 and encapsulated probiotics, Conventional orange juice
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Agricultural University of Athens
Type 1 Diabetes
Screening Program for Type 1 Diabetes in a High-Risk Population
Type 1 diabetes mellitus (T1D) is a growing public health concern in Saudi Arabia, ranking ninth globally in T1D incidence and tenth in T1D prevalence in children, and the rates are expected to rise and incur greater healthcare…
- Trial name
- NCT06513247
- Testing
- screening for Islet autoantibody, HLA phenotype and genetic risk score
- Where
- Saudi Arabia
- Volunteers
- 1,300 people
- Sponsor
- King Saud University
Atherosclerosis, High Blood Pressure
Latinos Understanding the Need for Adherence
The Latino population in the United States is increasing in size; is diverse in culture, backgrounds and countries of origin; is experiencing unique influences from social and behavioral acculturation to the U.S.; is reported…
- Conditions
- Atherosclerosis, High Blood Pressure, Type 2 Diabetes Mellitus, Heart Disease
- Trial name
- LUNA (NCT02955238)
- Testing
- Special Intervention
- Where
- United States
- Volunteers
- 587 people
- Sponsor
- San Diego State University
Type 2 Diabetes, Metabolic Syndrome
Acute Dose Response of Korean White Ginseng in Metabolic Syndrome or Type 2 Diabetes
The study is a Phase-I like double blind randomized placebo controlled crossover design trial. The objective is to assess the dose response relationship on glycemic and vascular effects of an acutely administered Korean White…
- Trial name
- KWG (NCT01699074)
- Testing
- 1 gram of White Korean Ginseng, 3 grams of White Korean Ginseng, 6 grams of White Korean Ginseng
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Endometrial Cancer, Genetic Predisposition
Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors
Endometrial cancer (EC) is one of the most prevalent cancers in women worldwide with a significantly increasing incidence, especially in developed countries.
- Conditions
- Endometrial Cancer, Genetic Predisposition, Risk Behavior
- Trial name
- MPEC (NCT06680791)
- Where
- Czechia
- Volunteers
- 280 people
- Sponsor
- Lukas Vanek
Cardiovascular Diseases, Heart Diseases
Improving Prevention of Heart Disease in Latinos
The purpose of the study is to improve cardiovascular disease (CVD) outcomes in racial and ethnic minorities. Specifically, it seeks to improve the primary prevention of CVD in Hispanics.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Diabetes Mellitus
- Trial name
- LUCHAR (NCT00101530)
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breast Cancer, Diabetes
Risk Communication Within Mexican-American Families
This study will examine what methods work best for encouraging Mexican-American family members to talk about their risk for diabetes, heart disease, breast cancer and colon cancer.
- Conditions
- Breast Cancer, Diabetes, Colon Cancer, Cardiovascular Disease
- Trial name
- NCT00469339
- Testing
- Family Health History
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Diabetes
Evaluation of a Noninvasive Diabetes Screening Device in Subjects at Risk for Diabetes
The purpose of this research study is to test the safety and effectiveness of the SCOUT DS in measuring the concentration of substances (advanced glycation endproducts) in the skin.
- Trial name
- ENGINE (NCT01080157)
- Testing
- SCOUT DS measurement
- Where
- 12 sites in United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Type2 Diabetes Mellitus
Adipose Tissue Expandability and Type 2 Diabetes
The goal of the study is to analyze deviations in adipogenic potential and metabolic properties of preadipocytes in subjects with genetic predisposition to type 2 diabetes, and thus identify factors that underlie hypertrophic…
- Trial name
- LIMEX (NCT03155412)
- Where
- Czechia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Type 1 Diabetes, Cardiovascular Diseases
Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes
The aim of this clinical trial is to evaluate if colchicine in addition to standard of care improves markers of inflammation and cardiovascular disease in persons with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Cardiovascular Diseases, Chronic Inflammation
- Trial name
- REC1TE (NCT05949281)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Asger Lund, MD
Type 2 Diabetes Mellitus, Health Adult Subjects
Sleep Quality, Adiposity and Diet Quality
The aim of this study is to evaluate the effects of sleep quality on cardiovascular disease risk and food and nutrient intakes. Within the scope of this study, several parameters associated with cardiovascular disease risk will…
- Trial name
- Obesity (NCT07870122)
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Intra-abdominal Fat, Metabolic Syndrome
Habitual Diet and Avocado Trial
The Habitual Diet and Avocado Trial will evaluate the effects of providing one avocado per day for recommended consumption over a 6 month period in a cohort of approximately 1000 free-living participants with increased waist…
- Conditions
- Intra-abdominal Fat, Metabolic Syndrome, High Cholesterol, Triglycerides High
- Trial name
- HAT (NCT03528031)
- Testing
- Intervention Daily Avocado
- Where
- 4 sites in United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gestational Diabetes
The Use of Early Pregnancy HbA1c in Predicting Excessive Fetal Growth in Women at Risk of Glucose Intolerance
The association of hyperglycaemia in pregnancy (gestational diabetes mellitus; GDM) with adverse maternal and fetal outcomes is clearly recognised.
- Trial name
- SHAPE (NCT04858386)
- Where
- United Kingdom
- Volunteers
- 1,314 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Diabetes Mellitus, Type 2
Understanding of Genetic Risk Information for Type 2 Diabetes
This research study is being conducted to learn about how health and genetic literacy (i.e., how well a person understands health and genetic information) affects a person's ability to understand genetic risk information for Type…
- Trial name
- NCT01186354
- Testing
- Receiving results via genetic counselor
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
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