Clinical trials: Diabetes Mellitus Risk
Diabetes Mellitus Risk, PreDiabetes
The Impact of a Mobile Application Designed for Adults at Risk of Developing Diabetes
Aim: The aim of this study is to determine whether a prediabetes mobile application (PREDIABE-TR) designed in Turkish to inform and advise individuals at risk of developing diabetes about healthy eating and physical exercise can…
- Trial name
- MobileApp (NCT05592288)
- Testing
- PREDIABE-TR mobile app.
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Akdeniz University
Type 1 Diabetes, Hypoglycemia
Stimulated Glucagon as a Biomarker of Hypoglycemic Risk in Type 1 Diabetes
Type 1 diabetes (T1D) results from destruction of insulin producing beta cells by the body's own immune system (autoimmunity) causing an individual to lose the ability to make enough insulin to control their blood sugar levels…
- Trial name
- MUGGLE (NCT05616273)
- Testing
- Mixed Meal Tolerance Test (MMTT), Arginine Stimulation Test (AST), Home Finger Prick Sample
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- University of Exeter
Cancer, Diabetes Mellitus, Type 2
SGLT2 Inhibitors and Reducing the Risk of Cancers Among Diabetics , an Observational Study
Since the discovery of SGLT2 inhibitors, there is a great shift in diabetic treatment, so this drug is magic, this drug can reduce the blood sugar level by blocking the reabsorption of glucose in the kidney and increasing glucose…
- Conditions
- Cancer, Diabetes Mellitus, Type 2, Interleukin 6, SGLT2 Inhibitors
- Trial name
- NCT05612269
- Testing
- interleukin 6
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Obesity, Metabolic Syndrome
Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants
Obesity represents one of the most important public health challenges for the societies. Although excess energy intake and physical inactivity are major causes of obesity and cardiometabolic disorders, emerging evidence has…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT02589756
- Testing
- The fatty fish group, The nut group, The control group
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Physical Inactivity, Cardiovascular Risk Factor
The Clinical Referral to Activity Study
The main aim of this effort is to test a physical activity intervention, for adult clinical care patients at risk of developing cardiovascular disease.
- Conditions
- Physical Inactivity, Cardiovascular Risk Factor, Obesity, Blood Pressure
- Trial name
- NCT04743856
- Testing
- ActiveGOALSv2, PAT
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hypertension, Cardiovascular Disease
Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women
Cardiovascular disease (CVD) is the leading cause of death in American women, claiming on average 40% of all female deaths each year.
- Conditions
- Hypertension, Cardiovascular Disease, Metabolic Disorders
- Trial name
- NCT00387166
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Obesity, Diabetes
"Working for You" Workplace Obesity Intervention
The purpose of this study is to test a workplace intervention program targeted at low SES workers. Working in partnership with BJC HealthCare, we will test an innovative multi-level intervention that includes an interactive…
- Trial name
- NCT02934113
- Testing
- iOTA, HWPP
- Where
- United States
- Volunteers
- 1,283 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Schizophrenia, Schizoaffective Disorder
Improving Diabetes Risk Factors in Persons With Schizophrenia or Bipolar Disorder by Switching to Ziprasidone
Having a diagnosis of schizophrenia or bipolar disorder and being treated with certain of the newer antipsychotics are risk factors for development of diabetes.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00538642
- Testing
- ziprasidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Type 2
Risk of Cardiovascular Events in Patients With Type 2 Diabetes Initiating Oral Antidiabetic Treatments
The purpose of this study is to compare the incidence of major cardiovascular events among patients with type 2 diabetes who are new initiators of Saxagliptin and those who are new initiators of oral anti-diabetic drugs (OADs)in…
- Trial name
- NCT01086280
- Volunteers
- 113,505 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
The goal of this pragmatic trial is to provide Real World Evidence (RWE) on the impact of the result of a polygenic risk prediction test of cardiorenal complications of T2D, so that more patients at high risk of these…
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Diabetic Nephropathy Type 2
- Trial name
- GENOCORDIA (NCT06586203)
- Testing
- Polygenic Risk Score
- Where
- 2 sites in Canada
- Volunteers
- 2,714 people
- Sponsor
- Optithera
Type 2 Diabetes, Microvascular Coronary Artery Disease
Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics with Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM)
The study design is a double blinded randomised control trial study that aims to conduct a randomised controlled trial of empagliflozin and determine if empagliflozin will improve myocardial blood flow in asymptomatic high risk…
- Trial name
- CATCH-EM (NCT04541797)
- Testing
- Empagliflozin 10 MG, Stress Cardiac Magnetic Resonance
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Health Behavior, Health Knowledge, Attitudes, Practice
DIMINI - Diabetes Mellitus? - Not me!
The increasing prevalence of type 2 diabetes mellitus is a worldwide problem. In preventing risk factors and unhealthy lifestyle through improved health literacy, chances are seen to delay or even avoid type 2 diabetes mellitus.
- Conditions
- Health Behavior, Health Knowledge, Attitudes, Practice, Literacy, Diabetes Mellitus, Type 2
- Trial name
- Dimini (NCT03482674)
- Testing
- DIMINI lifestyle intervention
- Where
- Germany
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Dimini Konsortium
Exercise, Mobile Health
Monitored Home Exercise in Pregnancy
The Study Investigators intend to study the adherence to and effect of a prescribed, monitored at-home exercise regimen in a pregnant population at risk for gestational diabetes, with a specific goal of understanding factors…
- Conditions
- Exercise, Mobile Health, Pregnancy, Gestational Diabetes
- Trial name
- NCT03551535
- Testing
- Monitored, At-Home Exercise Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prostate Cancer
Lifestyle Intervention to Improve Insulin Sensitivity and Markers of Cardiovascular Risk in Prostate Cancer Survivors
The purpose of this study is to discover if intensive lifestyle changes (such as diet and increased physical activity) improve the body's sensitivity to insulin, and therefore help prevent diabetes and other cardiovascular…
- Trial name
- NCT00738140
- Testing
- Diabetes Prevention Program
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Prediabetes, Cardiovascular Risk Factors
A Survey to Evaluate the Cardiovascular Risk Status of Subjects With Pre-Diabetes in Hong Kong
Hypothesis: A high cardiovascular risk is present in subjects with pre-diabetes in Hong Kong Chinese. The investigators plan to assess Chinese subjects in Hong Kong who have pre-diabetes (impaired fasting glucose, IFG; or…
- Trial name
- JADE-HK2 (NCT00786890)
- Testing
- observational, no intervention needed
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Diabete Type 1
Cardiopulmonary Fitness and Health-Related Quality of Life in Children and Adolescents With Type 1 Diabetes (FIT-T1D)
Children and adolescents with type 1 diabetes (T1D) are at risk of a sedentary lifestyle, as this chronic disease may lead patients into a vicious cycle of deconditioning, resulting in reduced physical activity levels and…
- Trial name
- FIT-T1D (NCT07728435)
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Institut Saint Pierre
Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases
Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD
To evaluate the relationship of baseline toenail chromium concentrations to weight loss, as well as the interaction between heavy metals and the beneficial effects of weight loss.
- Conditions
- Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases, Obesity, Myocardial Infarction
- Trial name
- NCT00031213
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Renal Disease, Diabetic Foot
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Context and hypothesis: The prevalence of diabetes mellitus keeps going to increase, due to the ageing of the population and the high prevalence of overweight and obesity.
- Trial name
- NEPHROPOD (NCT04100551)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Gestational Diabetes
Metabolic Risk Following Gestational Diabetes Mellitus
Gestational diabetes (GDM) is defined by abnormal glucose tolerance during gestation. This complication occurs in 4-10% and is associated with fetal complications and macrosomia.
- Trial name
- IMAGE (NCT02133729)
- Testing
- Blood sampling and OGTT
- Where
- 7 sites in France
- Volunteers
- 255 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Retinopathy, Ranibizumab
Multicenter Clinical Study of Anti-VEGF Treatment on High Risk Diabetic Retinopathy (DR)
The purpose of this study is to determine the efficacy and safety of intravitreous ranibizumab treatment versus sham injections for prevention of high-risk DR.
- Trial name
- NCT03452657
- Testing
- Ranibizumab, No drug
- Where
- 7 sites in China
- Volunteers
- 118 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
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