Clinical trials: Diabetes Mellitus Risk
Gestational Diabetes
The OHSU Pregnancy Exercise & Nutrition (PEN) Program
Personal behaviors can influence development of Gestational Diabetes Mellitus (GDM), a condition that can adversely affect the pregnant woman, her developing fetus and future events for both.
- Trial name
- PEN (NCT01719406)
- Testing
- Intervention, behavioral lifestyle education
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity Difficult Airway Airway Management, Obesity Adult Onset
OBESIAL: A Prospective Interventional Real-world Study of a Multidisciplinary Obesity Management Programme
The OBESIAL (Obesity Structured Intervention in Algeria) study aims to evaluate the clinical, metabolic, and organisational impact of a structured multidisciplinary obesity care pathway implemented under real-world conditions.
- Conditions
- Obesity Difficult Airway Airway Management, Obesity Adult Onset, Obesity and Cardiovascular Risk, Obesity Type 2 Diabetes Mellitus
- Trial name
- OBESIAL (NCT07779343)
- Testing
- Semaglutide (Wegovy) weekly injection, Behavioral Treatment, Weight loss
- Where
- Algeria
- Volunteers
- 300 people
- Sponsor
- University of Health Sciences, Algeria
Diabetes Mellitus, Type 2
Effects of Empagliflozin-Metformin, Sitagliptin-Metformin, and Metformin on Adipokines in Type 2 Diabetes
This study compared the impacts of empagliflozin-metformin, sitagliptin-metformin, and metformin monotherapy in treatment-naive overweight or obese adults with newly diagnosed type 2 diabetes mellitus in Erbil, Iraq.
- Trial name
- NCT07531108
- Testing
- Empagliflozin-Metformin, Sitagliptin-Metformin, Metformin
- Where
- Iraq
- Volunteers
- 186 people
- Sponsor
- Hawler Medical University
Diabetes and Risk of Diabetic Foot Ulcer
Pressure and Diabetic Foot
Diabetic foot ulcer (DFU) is a worldwide burden in the management of patients with diabetes. Peripheral neuropathy has a key role in the physiopathology of DFU.
- Trial name
- PIV & MPP (NCT03213093)
- Testing
- Measure of cutaneous microcirculation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes Mellitus, Obesity
Soluble Dietary Fibres in the Prevention of Type 2 Diabetes Mellitus
Controlling the glycemic impact of foodstuffs (by reducing the glycemic load of the diet by using soluble dietary fibres) may reduce the glycemic or insulinemic response.
- Trial name
- NCT01163006
- Testing
- Polydextrose and soluble gluco fibre
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
CKD - Chronic Kidney Disease, Diabetes Mellitus Type 2
Evaluation of the Risk of Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus
The goal of this study, performed entirely with computer programs, is to learn if using a combination of two drugs works better than using one alone, in the treatment of people with chronic kidney disease and type 2 diabetes…
- Trial name
- NCT07719621
- Where
- Spain
- Volunteers
- 100,000 people
- Sponsor
- Aeterna Medical Solutions SL
Prediabetic State
A Study of Attitudes About the Risk of Developing Type 2 Diabetes
Diabetes mellitus (DM) type 2 is well recognized as a major cause of morbidity and mortality in the United States, as well as a significant contributor to health disparities within the population.
- Trial name
- NCT00323349
- Testing
- Oral Glucose Tolerance Testing, Education tailored to learning style preferences
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Type 2 Diabetes Mellitus, Insulin Resistance
Impact of Overfeeding and Following Exercise Training in Individuals With and Without Increased Risk of Type 2 Diabetes
Low birth weight (LBW), a marker of impaired fetal growth is an independent and strong risk factor for type 2 diabetes (T2D). A western lifestyle characterized by a surplus of calories, and/or a low physical activity level…
- Conditions
- Type 2 Diabetes Mellitus, Insulin Resistance, Dyslipidemia
- Trial name
- NCT02982408
- Testing
- High carbohydrate overfeeding, Exercise, Normal physical activity
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes Mellitus
Carotid Wall Texture as a Cardiovascular Risk Biomarker in Type 2 Diabetes Mellitus
This study aims to compare carotid intima-media thickness (CIMT) and layer-specific texture characteristics of the carotid wall between individuals with Type 2 diabetes mellitus (T2DM) and normoglycemic controls, to assess the…
- Trial name
- NCT07373938
- Testing
- SCORE2, SCORE2-Diabetes, Ultrasound Assessment
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Obesity, Smoking
Africa and Middle East Cardiovascular Epidemiological Study
This is a cross-sectional, epidemiological study to determine the prevalence of cardiovascular risk factors such as obesity, smoking, dyslipidemia, diabetes mellitus and hypertension in patients attending General Practice clinics…
- Conditions
- Obesity, Smoking, Dyslipidemia, Diabetes Mellitus
- Trial name
- ACE (NCT01243138)
- Where
- 73 sites in Algeria, Cameroon and 12 more
- Volunteers
- 4,386 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
High Risk Hypertensive Patients
Study to Improve Quality of Care and Patient Health in the Field of Cardiovascular Risk Factors in General Practice
Observational studies performed in France and abroad in hypertensive patients at high cardiovascular risk have shown a wide gap between the therapeutic targets reached in ambulatory patients and those set by guidelines.
- Trial name
- ESCAPE (NCT00348855)
- Testing
- Cardiovascular drugs strategies, Compliance, Exercise
- Where
- 2 sites in France
- Volunteers
- 1,836 people
- Sponsor
- Collège National des Généralistes Enseignants
Diabetes, Diabetes Mellitus, Type 2
Mindfulness IN-home for Diabetes and Sleep Health
The study investigates the effects of a mindfulness intervention on sleep and subsequent cardio-metabolic risk in an adult Atlanta population aged 18 and older.
- Trial name
- MINDS (NCT04160078)
- Testing
- Mindfulness-based stress reduction (MBSR) Intervention
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Obesity, Cardiovascular Disease
Role of Cardiometabolic Risk Factors in Childhood Bone Development
The proposed research brings together complementary expertise to systematically elucidate the longitudinal effects of (1) total and regional body fat and (2) the metabolic impairment that accompanies obesity on bone development…
- Conditions
- Obesity, Cardiovascular Disease, Type 2 Diabetes, Osteoporosis
- Trial name
- NCT02355717
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Augusta University
Birth Defects, Type 2 Diabetes
Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy
This is an observational, prospective cohort study describing pregnancy outcomes in women with pre-existing (prior to pregnancy) type 2 diabetes who have been exposed to any formulation of exenatide during pregnancy.
- Conditions
- Birth Defects, Type 2 Diabetes, Preterm Birth
- Trial name
- Exenatide (NCT00579150)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- AstraZeneca
Diabetic Polyneuropathy
Differential Air Pressure Technology for Treatment of Diabetic Elderly Patients
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT04620265
- Testing
- Antigravity treadmill training 100% weight bearing, Antigravity treadmill training 75% weight bearing, Antigravity treadmill training 50% weight bearing
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- Umm Al-Qura University
Diabetes
DHS MIND Metabolomics
The study team will evaluate whether metabolomic signatures of neurocognitive decline trajectories are exacerbated by the presence of type 2 diabetes mellitus (T2D) and whether these signatures contribute in part, to ethnic…
- Trial name
- NCT03975309
- Where
- United States
- Volunteers
- 417 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Diabetes
Role of Nutrition and Maternal Genetics on the Programming of Development of Fetal Adipose Tissue
In the PREOBE projects it is aimed to obtain genetic and biochemical biomarkers for the programming of obesity in early stages of life.
- Trial name
- PREOBE (NCT01634464)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Diabetes Mellitus, Type 2, Lifestyle Risk Reduction
Patient-Driven Lifestyle Modification Using FreeStyle Libre in Type 2 Diabetes Patients
We aim to provide medical nutritional therapy to patients with type 2 diabetes who are on oral hypoglycemic agents or on basal insulin only and monitor the glycemic response with flash glucose monitoring or self-monitoring of…
- Trial name
- PDF (NCT04932928)
- Testing
- FreeStyle Libre, Blood glucose meter
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
Pregnancy, Gestational Diabetes
Targeted Lifestyle Change Group Prenatal Care
To conduct a randomized trial to determine the effect of Targeted Lifestyle Change Group Prenatal Care (TLC) on maternal and neonatal outcomes in women at high risk for developing gestational diabetes mellitus (GDM).
- Trial name
- TLC (NCT04090307)
- Testing
- TLC Group Prenatal Care
- Where
- 2 sites in United States
- Volunteers
- 305 people
- Sponsor
- University of North Carolina, Chapel Hill
Abdominal Obesity, Metabolic Syndrome
Growth Hormone Treatment in Men With High Risk of Developing Type 2 Diabetes Mellitus
The overall aim of this study is to investigate the effects of GH treatment in men with the Metabolic Syndrome and a high risk of developing type 2 DM.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Obesity
- Trial name
- GHDM (NCT00781547)
- Testing
- recombinant human growth hormone
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
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