Clinical trials: Diabetes Mellitus Type 2 (T2DM)
T2DM With Inadequate Glycemic Control
CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM)
The objective of the study is to compare the efficacy and safety of 3 doses CS02 Tablet in combination with a stable dose of metformin monotherapy against CS02 PTM (placebo) Tablet in combination with a stable dose of metformin…
- Trial name
- NCT03317028
- Where
- 13 sites in United States, Taiwan
- Volunteers
- 201 people
- Sponsor
- Center Laboratories, Inc.
Type2 Diabetes
Chronic Passive Heating in Individuals With T2DM
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterized by chronic hyperglycemia and progressive insulin resistance, which progressively lead to macro- and microvascular damage and subsequent impairments in blood…
- Trial name
- NCT04858321
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Portsmouth
Type 2 Diabetes
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)
The main reason for this study is to compare the study drug tirzepatide to insulin glargine in participants with type 2 diabetes on metformin with or without a sulfonylurea.
- Trial name
- NCT04093752
- Testing
- Tirzepatide, Insulin Glargine
- Where
- 67 sites in Australia, China and 2 more
- Volunteers
- 917 people
- Sponsor
- Eli Lilly and Company
Diabetes
Duodenal Exclusion for the Treatment of Type 2 Diabetes
The purpose of this study is to investigate the role of an experimental surgery that may offer better short and long-term control of T2DM in select patients who have not achieved adequate blood sugar control with regular means.
- Trial name
- NCT00534547
- Testing
- Duodenal Exclusion
- Sponsor
- Medtronic - MITG
Type 2 Diabetes Mellitus (T2DM), Hypertension (HTN)
Cohort Study of Metabolic Disease and Hypertension
The goal of this observational study is to learn how type 2 diabetes and high blood pressure develop over time in adults in Mexico.
- Trial name
- NCT07577063
- Testing
- Observational Study
- Where
- Mexico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Type2diabetes
Effects of Metformin Therapy on Pancreatic and Hepatic Fat Content in Patients of Type 2 Diabetes Mellitus
A sample size of 15 patients with T2DM visiting Fortis C DOC Hospital will be recruited with informed, written consent and will be requested to answer a validated questionnaire in a language known to them (English/Hindi).
- Trial name
- NCT05939921
- Testing
- Metformin
- Where
- India
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Type 2 Diabetes Mellitus (T2DM), Recurrent Urinary Tract Infections
Cranberry Proanthocyanidins and Lactobacilli for Recurrent UTI Prevention in Type 2 Diabetes
The purpose of this prospective, single-arm feasibility study was to evaluate the operational feasibility, tolerability, safety, and exploratory clinical outcomes of an oral supplement combining standardized cranberry…
- Trial name
- NCT07832409
- Testing
- Cranberry Proanthocyanidins and Lactobacilli
- Where
- Georgia
- Volunteers
- 100 people
- Sponsor
- National Institute of Endocrinology, Georgia
T2DM, Type 2 Diabetes Mellitus
A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Placebo in T2DM Patients
The main purpose of this study is to investigate the efficacy and safety of XW003 versus placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled by diet and exercise alone
- Trial name
- NCT05680155
- Testing
- Ecnoglutide
- Where
- China
- Volunteers
- 211 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Type 2 Diabetes Mellitus (T2DM)
Effects of Saxagliptin on Adipose Tissue Inflammation in Humans
In this research study, Investigators will be comparing the effects of a medication Saxagliptin versus placebo (a similar looking pill that contains no medication) on inflammation in the body.
- Trial name
- NCT02285985
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Phoenix VA Health Care System
Type 2 Diabetes Mellitus (T2DM), Diabetes Self-Management Education
Effects of Online Diabetes Self-management Education on Knowledge Retention, BMI, and HbA1c in Newly Diagnosed Adults With Type 2 Diabetes
Type 2 diabetes requires active self-management from the time of diagnosis, but participation in traditional face-to-face diabetes self-management education is often limited by access-related and personal barriers.
- Trial name
- NCT07669038
- Testing
- Online Diabetes Self-Management Education, Traditional Face-to-Face Diabetes Self-Management Education
- Where
- Slovenia
- Volunteers
- 123 people
- Sponsor
- University of Primorska
Type 2 Diabetes Mellitus (T2DM)
Comparative Cardiovascular Effectiveness of GLP-1 RAs vs. Insulin in Early-Onset Type 2 Diabetes
The incidence of early-onset type 2 diabetes (T2D) is increasing globally. People with early-onset T2D have faster beta-cell deterioration and more aggressive diabetes progression than their late-onset counterparts.
- Trial name
- NCT06913881
- Testing
- GLP-1
- Where
- Sweden
- Volunteers
- 92,100 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus (T2DM), Overweight , Obesity
A Study to Evaluate Different Administration Conditions and the Food Effect of MWN109 Tablets in Chinese Participants
This is a randomized, open-label, multiple-dose study to evaluate the effects of different volumes of administration water, post-dose fasting duration, and high-fat diet on the pharmacokinetics of the 15 mg dose of MWN109 tablets…
- Trial name
- NCT07801326
- Testing
- MWN109 Tablets
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Diabete Mellitus
Cardiovascular Disease CVD Constitutes a Significant Health Challenge for Individuals With Type 2 Diabetes Mellitus T2DM, Affecting Approximately 32% of This Population and Contributing Significantly to Global Mortality.Visceral Adipose Tissue VAT Accumulation Has Been Recognize
calculate cardiovascular risk scores in type 2 DM patients, then estimate its association with new visceral adipose tissue indices
- Trial name
- NCT07204782
- Where
- Egypt
- Volunteers
- 238 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus
Freestyle Libre-based Education on MDI in T2DM (FreEdoM-2)
Multicenter, Open-label, Randomized Trial to Compare the Effectiveness of Structured Education and Safety of FreeStyle Libre or Self-Monitoring of Blood Glucose (SMBG) in patients with type 2 Diabetes Mellitus using Multiple…
- Trial name
- NCT04926623
- Testing
- FreeStyle Libre 24 weeks, SMBG (22 weeks) and blind CGM (2 weeks)
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
T2DM, Diabete Type 2
Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and Metformin
Phase 3 study to assess the Efficacy and Safety of CT-L02-301 in Type 2 Diabetes Patients with Insufficient Glycemic Control with Metformin and Alogliptin Combination Therapy.
- Conditions
- T2DM, Diabete Type 2, DM
- Trial name
- NCT07093476
- Testing
- Metformin, Alogliptin, empagliflozin
- Where
- South Korea
- Volunteers
- 171 people
- Sponsor
- Celltrion
Type 2 Diabetes
Effect of Saxagliptin on EPCs as a Cellular Biomarker for Evaluating Endothelial Dysfunction in Early T2DM Patients
Type 2 diabetes is a national epidemic. Diabetes has undesirable effects on blood vessels which may contribute to heart disease. Endothelial Progenitor Cells(EPCs) are found in the blood .
- Trial name
- NCT02024477
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- George Washington University
Type 2 Diabetes (T2DM), Cardiovascular Disease
The Effectiveness of Resistance Training on Glycemic Control for Patients With Type 2 Diabetes in Cardiac Rehabilitation
This study is designed to investigate the effect of a structured resistance training program on glycemic control, measured by hemoglobin A1c (glycated hemoglobin), in patients with type 2 diabetes (T2DM) who are enrolled in…
- Trial name
- NCT02707380
- Testing
- Resistance Training, Standard of Care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes Mellitus (T2DM)
Helping Adults With Type 2 Diabetes Use Their Health Data for Healthy Diabetes Self-Management
Day-to-day self-management by adults with type 2 diabetes, including glucose monitoring, taking medications, and healthy habits, is essential to avoid diabetes complications, yet, despite the rapidly expanding availability of…
- Trial name
- MPowerHub (NCT06848361)
- Testing
- MPowerHub, Continuous Glucose Monitor (CGM), Activity Monitor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ann-Marie Rosland
Type 2 Diabetes Mellitus (T2DM), Obesity Type 2 Diabetes Mellitus
Evaluation of Neuregulin-4 (NRG4) Levels in Obese and Non-Obese Patients With Type 2 Diabetes Mellitus
This prospective observational study aims to evaluate serum Neuregulin-4 (NRG4) concentrations in obese and non-obese adults with Type 2 Diabetes Mellitus (T2DM) and to investigate their association with obesity status, insulin…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NRG4-T2DM (NCT07734558)
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- GÜLDEN ANATACA
Diabetes Mellitus, Type 2, Coronary Artery Disease
Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
The purpose of this study is to determine whether bromodomain extraterminal domain (BET) inhibition treatment with RVX000222 in high-risk type 2 diabetes mellitus patients with coronary artery disease increases the time to major…
- Trial name
- BETonMACE (NCT02586155)
- Testing
- Apabetalone, Atorvastatin, Rosuvastatin
- Where
- 214 sites in Argentina, Australia and 13 more
- Volunteers
- 2,425 people
- Sponsor
- Resverlogix Corp