Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Type 2 Diabetes Mellitus
Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)
This study will examine the efficacy of omarigliptin 25 mg once weekly compared to placebo in Japanese patients with T2DM who have inadequate glycemic control on insulin monotherapy in addition to diet and exercise therapy.
- Trial name
- NCT02906709
- Testing
- Omarigliptin, Insulin
- Volunteers
- 184 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus (T2DM), Oxidative Stress
Effect of Rosmarinus Officinalis Extract on Oxidative Stress and Inflammatory Biomarkers in Patients With Type 2 Diabetes (T2DM)
This randomized, placebo-controlled clinical trial evaluates the effects of a methanolic extract of Rosmarinus officinalis (rosemary) in patients with type 2 diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Oxidative Stress, Inflammation Chronic
- Trial name
- T2DM (NCT07541729)
- Testing
- Rosmarinus officinalis extract
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma de Zacatecas
Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management
Technology-Based Education and Follow-Up in Type 2 Diabetes Management
This study aims to evaluate whether a nurse-led, technology-based education and follow-up program can improve diabetes management in individuals with type 2 diabetes. Participants were randomly assigned to two groups.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management, Glycemic Control
- Trial name
- PAS-DM (NCT07513961)
- Testing
- Technology-Based Diabetes Education and Follow-up System (PAS-DM)
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Alanya Alaaddin Keykubat University
Diabetes, Hypothyroidism
Thyroid Study Type 2 Diabetes Mellitus (T2DM)
Background of the study: Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are known to promote weight loss, which could be beneficial for treating obesity, and type 2 diabetes.
- Trial name
- NCT01379170
- Testing
- Euthyrox (levothyroxine)
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
T2DM (Type 2 Diabetes Mellitus)
Effects of Berberine Ursodeoxycholate (HTD1801) Versus Dapagliflozin in Patients With Type 2 Diabetes Inadequately Controlled With Metformin
The goal of this clinical study is to evaluate the efficacy and safety of berberine ursodeoxycholate (HTD1801) compared to dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin alone.
- Trial name
- HARMONY (NCT06415773)
- Testing
- HTD1801, Dapagliflozin
- Where
- 53 sites in China
- Volunteers
- 367 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Diabetes Mellitus, Type 2
Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM
To evaluate the effect of the combination of chromium picolinate (600 μg Cr) + biotin (2 mg) versus placebo on glycosylated hemoglobin (HbA1c), lipid profiles (Total-C, HDL-C, LDL-C, TGs, TG/HDL ratio, etc), and pharmacoeconomic…
- Trial name
- NCT00289354
- Testing
- Chromium Picolinate (600 mcg Cr) + biotin (2 mg)
- Volunteers
- 600 people
- Sponsor
- Nutrition 21, Inc.
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal
The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in…
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Tobacco Smoking
- Trial name
- SCALE NCD (NCT06740708)
- Testing
- SCALE-NCD
- Where
- Nepal
- Volunteers
- 2,100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type 2 Diabetes
Mediterranean Diet vs DASH and MIND in T2DM
In our study, we aimed to comparatively evaluate the relative effects of the Mediterranean, DASH, and MIND diets on metabolic parameters in individuals with type 2 diabetes.
- Trial name
- NCT07310225
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Diabete Type 2
Reversibility of Brain Glucose Transport and Metabolism in T2DM: an Intervention Study
This study is designed to test if there is a difference in brain glucose transport kinetics in poorly controlled T2DM individuals with short duration and long duration of diabetes, using non-invasive magnetic resonance…
- Trial name
- NCT04283617
- Testing
- Intensification of insulin regimen/Nutrition
- Where
- United States
- Sponsor
- Yale University
Type 2 Diabetes Mellitus
CAPTIVATE India - A Study to Assess the Prevalence of Cardiovascular Disease (CVD) in Individuals With Type 2 Diabetes Mellitus (T2DM) in India
This is a cross-sectional study assessing the prevalence of Cardiovascular Disease and describing cardio-renal risk factors among individuals with Type 2 Diabetes Mellitus in India based on medical records.
- Trial name
- NCT07121114
- Testing
- No treatment given
- Where
- India
- Volunteers
- 1,500 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus
A Study on Safety and Tolerability of SAR425899 in Overweight to Obese Subjects and Type 2 Diabetes Mellitus Patients Not Requiring Anti-Diabetic Pharmacotherapy With an Optional 6-month Safety Extension Period
Primary Objectives: Main study: To assess in overweight to obese subjects and type 2 diabetes mellitus (T2DM) patients not requiring anti-diabetic pharmacotherapy the safety and tolerability of 3 different dose escalation…
- Trial name
- NCT03414736
- Testing
- SAR425899
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sanofi
Type 2 Diabetes (T2DM), Obesity Type 2 Diabetes Mellitus
DIabetes GLycemic Assessment in Newly Confirmed Episodes
This is a prospective, open-label, randomized controlled trial involving 80 adult patients with newly diagnosed T2DM (diagnosed within the last 3 months) recruited at the Bogomolets National Medical University.
- Conditions
- Type 2 Diabetes (T2DM), Obesity Type 2 Diabetes Mellitus, Obesity & Overweight, Insulin Resistance
- Trial name
- DI-GLANCE (NCT07690163)
- Testing
- CGM Sibionics, On-Call Extra Glucometer
- Where
- 3 sites in Ukraine
- Volunteers
- 80 people
- Sponsor
- Nazarii Kobyliak
Type 2 Diabetes Mellitus, Hypertriglyceridemia
The Effect of Omega-3 FA on Hypertriglyceridemia in Patients With T2DM(OCEAN)
The purpose of this study is to conduct a multicenter randomized, double-blind, placebo-controlled clinical trial, evaluating the effects and change of lipid metabolism, especially of triglyceride after omega-3 administration in…
- Trial name
- NCT03120299
- Testing
- Omega-3 fatty acid
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes Mellitus, Type 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of JNJ-38431055 in Volunteers With Type 2 Diabetes Mellitus
This study will assess the safety, tolerability, pharmacokinetics (explores what the body does to the drug), and pharmacodynamics (explores what a drug does to the body) of multiple doses of JNJ-38431055 in volunteers with type 2…
- Trial name
- NCT00946972
- Volunteers
- 33 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Glucose Metabolism Disorders (Including Diabetes Mellitus), Metabolic Disease
Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM
This randomized controlled trial (RCT) with 250 patients suffering from type 2 diabetes mellitus (T2DM) aims to investigate the effectiveness of the self-guided digital therapeutic covivio.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Metabolic Disease, Endocrine System Diseases, Diabetes Mellitus, Type 2
- Trial name
- EASE-T2DM (NCT06529965)
- Testing
- covivio
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Gaia AG
Type 2 Diabetes Mellitus (T2DM)
Impact of LLL and Aerobic Exercise on Peripheral Arterial Outcomes in Patients With Type 2 Diabetes
Diabetes is one of the fastest-growing diseases worldwide, It has Devastating macrovascular complications (cardiovascular disease) and microvascular complications (such as diabetic kidney disease, diabetic retinopathy, and…
- Trial name
- LLLT (NCT06827171)
- Testing
- aerobic exercise + low-level laser therapy, Aerobic exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nouran Hesham Slama Younis
Nonalcoholic Fatty Liver Disease, Type 2 Diabetes
Dapagliflozin in Type 2 Diabetes Mellitus Patients (T2DM) With Nonalcoholic Fatty Liver Disease (NAFLD)
The aim of this study is to evaluate the effect of dapagliflozin on liver function of patient with NAFLD and T2DM.
- Trial name
- NCT05459701
- Testing
- Dapagliflozin 10mg Tab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Rehab Werida
Type 2 Diabetes Mellitus (T2DM)
A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
The main purpose of this study is to investigate the Efficacy and Safety of GZR18 Injection in Chinese Subjects with Type 2 Diabetes Mellitus and Poor Blood Glucose Control by Metformin Monotherapy or in Combination with…
- Trial name
- Optimum 2 (NCT06778967)
- Testing
- GZR18, semaglutide
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Care in the United States
This is an observational study in which data from people with chronic kidney disease (CKD) and Type 2 diabetes mellitus (T2D) are collected and studied.
- Trial name
- 22663 (NCT06608212)
- Testing
- Finerenone (Kerendia, BAY948862), Others except finerenone
- Where
- United States
- Volunteers
- 238,038 people
- Sponsor
- Bayer
Type 2 Diabetes Mellitus (T2DM)
Diabetes Management for Primary Healthcare Centers.
The purpose of this study, "Integrating diabetes care into Primary Healthcare Centers (PHCs) in Abuja, Nigeria: a pilot study," is to screen, diagnose, treat, and educate diabetes patients in two selected PHCs in Abuja.
- Trial name
- DM4PHC-pilot (NCT06907472)
- Testing
- Protocol-based treatment
- Where
- 2 sites in Nigeria
- Volunteers
- 106 people
- Sponsor
- University of Abuja