Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Diabetes
Mechanisms of Glucose Lowering Effects of Sitagliptin and Metformin Alone and in Combination in Patients With T2DM
In patients with type 2 diabetes with inadequate glycemic control on diet and exercise after 6 weeks of treatment: Objective: To assess the effects of co-administration of sitagliptin and metformin compared to placebo on hepatic…
- Trial name
- NCT00820573
- Testing
- Sitagliptin, Metformin, Sitagliptin + Metformin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes
A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Type 2 Diabetes Mellitus Subjects (T2DM) Treated With Basal + Prandial Insulin
This study will be conducted to compare the efficacy, safety and patient-reported outcome of once-weekly GZR4 and once-daily Insulin Glargine U100 in Combination with Insulin Aspart (with or without Non-Insulin Antidiabetic…
- Trial name
- NCT06767761
- Testing
- GZR4, Insulin Glargine U100 group
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Self-management, Type 2 Diabetes Mellitus (T2DM)
Development and Evaluation of a Culturally Sensitive Structured Diabetes Self-Management Program for People With Type 2 Diabetes Residing in Qatar
This study is about helping people in Qatar who have Type 2 Diabetes take better care of their health. Diabetes is a common and growing problem in Qatar, and many people need more support and information to manage it well in…
- Conditions
- Self-management, Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management
- Trial name
- PARADIGM-Q (NCT06948370)
- Testing
- Intervention Name: PARADIGM-Q Diabetes Self-Management Education Program, Control Arm (DESMOND): DESMOND Diabetes Self-Management Education Program
- Volunteers
- 200 people
- Sponsor
- Ragae Dughmosh
PreDiabetes, Myocardial Infarction
Effect of Dapagliflozin on the Progression From Prediabetes to T2DM in Subjects With Myocardial Infarction
It is hypothesize that, because dapagliflozin will reverse the metabolic defects responsible for the development of prediabetes (i.e.
- Conditions
- PreDiabetes, Myocardial Infarction, T2DM (Type 2 Diabetes Mellitus), CVD
- Trial name
- NCT03658031
- Testing
- Dapagliflozin 10mg
- Where
- Qatar
- Volunteers
- 576 people
- Sponsor
- Hamad Medical Corporation
Type 2 Diabetes (T2DM), Hyperglycemia
CGM-Based Glycemic Analysis After ESI
The goal of this clinical study is to learn how blood glucose levels change after an epidural steroid injection (ESI) with dexamethasone in adults.
- Conditions
- Type 2 Diabetes (T2DM), Hyperglycemia, Radicular Pain, Spinal Stenosis
- Trial name
- CGMSteroid (NCT07280780)
- Testing
- Epidural Steroid Injection, Continuous Glucose Monitoring
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Korea University Anam Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 2
Single Dose Study of PF-04991532 in Healthy Subjects
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK) and preliminary food effect of PF-04991532 following single escalating oral doses in healthy adult subjects.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- NCT01102673
- Testing
- PF-04991532
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM)
"Sexual Activity and Hypoglycemia Risk in Adults With Type 1 or Type 2 Diabetes Using Insulin Therapy and Continuous Glucose Monitoring"
This observational study examines whether sexual activity influences the risk of hypoglycemia in adults with type 1 or type 2 diabetes treated with insulin therapy and using continuous glucose monitoring (CGM).
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM), Hypoglycemia
- Trial name
- SEX-HYPO-CGM (NCT07286500)
- Testing
- No intervention
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Type 2 Diabetes Mellitus (T2DM)
hUC-MSC-Exosomes for T2DM - Safety & Efficacy
The goal of this clinical trial is to Evaluate the Safety and Preliminary Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Adult Type 2 Diabetes Mellitus.
- Trial name
- HOPE-T2DM (NCT07693036)
- Testing
- exosomes treatment group, control group
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University First Hospital
Diabetes
A Prospective, Open, Self-controlled Study of the Effects of Chiglitazar Sodium on Glucose and Lipid Metabolism in Patients With Type 2 Diabetes Mellitus (T2DM)
The goal of this clinical trial is to learn about inour study aimed to evaluate serum lipid profiles of T2DM patients before and after Chiglitazar Sodium administration.
- Trial name
- NCT06191328
- Testing
- Chiglitazar sodium
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yufan Wang
Type 2 Diabetes Mellitus (T2DM), Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus
Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide
This is a multicenter, prospective, randomized controlled investigator-initiated trial (IIT) aimed at evaluating the efficacy and safety of switching to mazdutide therapy in patients with type 2 diabetes mellitus (T2DM) and…
- Trial name
- NCT07713992
- Testing
- Mazdutide(Dual GLP-1R/GCGR Agonist), Semaglutide (1 Mg Dose)
- Volunteers
- 72 people
- Sponsor
- Tianjin Medical University
T2DM (Type 2 Diabetes Mellitus)
PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy
Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03155087
- Testing
- Metformin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- People's Hospital of Zhengzhou University
Safety Outcomes
Safety Of DAPAGLIFLOZIN (FORXIGA) in Patient With Type 2 Diabetes Mellitus (T2dm) In Vietnam From A Post-Marketing Surveillance Program
This study is conducted to meet the requirements of the Drug Administration of Vietnam (DAV) on conducting necessary safety evaluations in routine clinical practice for a new medication within 3 years from its date of approval.
- Trial name
- DAPAPMS (NCT07210307)
- Where
- Vietnam
- Volunteers
- 1,001 people
- Sponsor
- AstraZeneca
Type 2 Diabetes, Metabolic Dysfunction-Associated Steatotic Liver Disease
Metformin-Dapagliflozin Effects on IGF-1 in Male T2DM With MASLD
This is a 3-month, single-center, prospective, randomized, parallel-controlled, open-label trial investigating the effects of metformin combined with dapagliflozin on serum IGF-1 levels in male patients with type 2 diabetes…
- Trial name
- MDEITM (NCT07778719)
- Testing
- Metformin + Dapagliflozin, Metformin
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The 95th Hospital of Putian，Putian, Fujian, China
Type 2 Diabetes Mellitus (T2DM)
Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes
This clinical trial investigates the short-term effects of two commonly used non-nutritive sweeteners (NNS), saccharin and sucralose, on blood glucose regulation and the gut microbiota in adults with Type 2 Diabetes Mellitus…
- Trial name
- NCT07124585
- Testing
- Sucralose, Saccharin
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- National University of Malaysia
Diabetes Mellitus, Type 2, Cognitive Dysfunction, Epigenetics, Exercise
Using Polar Unite Fitness Watch to Improve Cognition for T2DM Patients
Type 2 diabetes mellitus (T2DM) impairs the brain, leading to cognitive dysfunction, which carries substantial lifetime consequences.
- Trial name
- NCT04603885
- Testing
- Aerobic exercise program, Stretching exercise
- Volunteers
- 42 people
- Sponsor
- University of Arkansas, Fayetteville
NAFLD, T2D
Prevalence of NAFLD in T2DM Patients
To determine the prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
- Conditions
- NAFLD, T2D, Type 2 Diabetes, Fatty Liver, Nonalcoholic
- Trial name
- PAD2ZOL (NCT06445335)
- Testing
- FibroScan
- Where
- Belgium
- Volunteers
- 385 people
- Sponsor
- Ziekenhuis Oost-Limburg
Type 2 Diabetes Mellitus (T2DM)
A Telenursing Program to Support Diabetes Self-Management
This randomized controlled trial aims to develop and evaluate a telenursing-based Diabetes Self-Management Education and Support (DSMES) program with uncontrolled type 2 diabetes mellitus in Thailand.
- Trial name
- NCT07366775
- Testing
- Telenursing-Based Diabetes Self-Management Education and Support
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Chiang Mai University
Type 2 Diabetes Mellitus, Metabolic Dysfunction-associated Steatotic Liver Disease
Liver Fat as a Dietary Target of the Chinese Medical Nutrition Therapy (CMNT) Diet for Treating Type 2 Diabetes With Nonalcoholic Fatty Liver Disease (Version 3.0)
This study aims to explore the efficacy of CMNT, an intermittent energy restriction (iER) intervention, in managing Chinese adults with type 2 diabetes and non-alcoholic fatty liver disease.
- Trial name
- NCT07083336
- Testing
- CMNT diet
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- State Key Laboratory of Subhealth Intervention Technology
Type 2 Diabetes Mellitus
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics After High Single Ascending Oral Doses of AZD1656 in T2DM Patients
The purpose of this study is to investigate safety and tolerability after high Single Ascending Oral Doses of AZD1656.
- Trial name
- NCT01221545
- Testing
- AZD1656
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Male Subjects With Type II Diabetes (T2DM)
Assessment of the Safety, Tolerability and Pharmacodynamics After Administration of One Dose of AZD8601 to Male Patients With Type II Diabetes Mellitus (T2DM)
This study will be a phase I, first time in human (FiH), randomized, single-blind, placebo-controlled, SAD study in male patients with T2DM, performed at a single study center.
- Trial name
- NCT02935712
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- AstraZeneca