Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive
Primary Objectives: To assess efficacy in terms of change from baseline in Hemoglobin A1c (HbA1c) at the end of study between the two drugs.
- Trial name
- ACADEMIC (NCT03794336)
- Testing
- Alogliptin, Acarbose, Metformin
- Where
- China
- Volunteers
- 1,293 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus (T2DM), Vitamin D Deficiency
Effect of Vitamin D Supplementation on Metabolic Parameters in Patients With Type 2 Diabetes and Vitamin D Deficiency
The goal of this clinical study is to learn whether vitamin D supplementation improves metabolic control in adults with type 2 diabetes mellitus who have vitamin D deficiency.
- Trial name
- VITD-DM2 (NCT07468721)
- Testing
- cholecalciferol (vitamin D3)
- Where
- Paraguay
- Volunteers
- 119 people
- Sponsor
- Faculty of Medical Sciences, Clinical Hospital
Type 2 Diabetes Mellitus
To Evaluate the Efficacy and Safety of JW0201 Added on in Patients With T2DM
A multicenter, randomized, double blind, placebo controlled, parallel, phase Ⅲ study to evaluate the efficacy and safety of JW0201 added on in patients with type 2 diabetes mellitus who have inadequate glycemic control with C2202…
- Trial name
- NCT05814406
- Testing
- JW0201
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- JW Pharmaceutical
Type 2 Diabetes Mellitus (T2DM)
Self Management of Type 2 Diabetes Using a Text Based Mobile Health (Mhealth) Intervention in Nepal
Background: The global prevalence of diabetes is increasing particularly in low and middle income countries like Nepal with the number expected to rise in the near future.
- Trial name
- NCT06623006
- Testing
- mobile health (mhealth)
- Where
- Nepal
- Volunteers
- 154 people
- Sponsor
- University of Huddersfield
Diabetes
A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin
This study will be conducted to compare the efficacy, safety and patient-reported outcome of once-weekly GZR4 and once-daily Insulin Degludec with or without Non-Insulin Antidiabetic Agents in subjects with Type 2 Diabetes…
- Trial name
- NCT06767748
- Testing
- GZR4, insulin degludec
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Gan & Lee Pharmaceuticals.
T2DM (Type 2 Diabetes Mellitus), CKD - Chronic Kidney Disease
Efficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
The purpose of this study is to evaluate whether adding dulaglutide to the combination therapy of Sodium-Glucose Co-Transporter 2 Inhibitors(SGLT2i) and finerenone can provide additional kidney protection and safety for Chinese…
- Trial name
- NCT07537088
- Testing
- Dulaglutide, SGLT2i, Finerenone
- Volunteers
- 468 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Type 2 Diabetes Mellitus (T2DM)
Endovascular Denervation for the Treatment of Type 2 Diabetes Mellitus
This is a prospective, multicenter, single group feasibility clinical trial to evaluate the safety and efficacy of Endovascular denervation for the treatment of type 2 diabetes mellitus (T2DM) using the Endovascular denervation…
- Trial name
- NCT05631561
- Testing
- Endovascular denervation System (Generator and Catheter )
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Assess the Effects of a the 90-day Oral TS Study Regimen on PSA, IPSS, Haemoglobin and Haematocrit, and to Assess Adverse and Serious Adverse Events.
The Effect of 90-day Oral Testosterone Therapy in Chinese Males With Type 2 Diabetes (T2DM)
The study hypothesis is that treatment with oral Testosterone according to the study regimen will improve glycemic control in T2DM Chinese males in Singapore as indicated by a reduction in HbA1c levels at study day 90.
- Trial name
- OTEST (NCT01510847)
- Testing
- Andriol Testocaps
- Where
- 12 sites in Singapore
- Volunteers
- 19 people
- Sponsor
- Singapore Clinical Research Institute
Healthy
Single Dose Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06291874 In Healthy Adult Subjects
The primary purpose of this trial is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of PF-06291874 in healthy volunteers.
- Trial name
- NCT01794364
- Testing
- PF-06291874
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus (T2DM), Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus
Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide
This is a multicenter, prospective, randomized controlled investigator-initiated trial (IIT) aimed at evaluating the efficacy and safety of switching to mazdutide therapy in patients with type 2 diabetes mellitus (T2DM) and…
- Trial name
- NCT07713992
- Testing
- Mazdutide(Dual GLP-1R/GCGR Agonist), Semaglutide (1 Mg Dose)
- Volunteers
- 72 people
- Sponsor
- Tianjin Medical University
Type 2 Diabetes Mellitus
Personality of Diabetic Patients Will Influence Their Medical compliance-a 5 Years Cohort Follow up With Type D Personality
Diabetes is one of the most common causes of death in Taiwan. With the raising prevalence of diabetes, it became the fourth most common cause of death since 2002.
- Trial name
- NCT01151293
- Sponsor
- Far Eastern Memorial Hospital
Type 2 Diabetes Mellitus (T2DM)
Clinical Study to Evaluate the Food Effect of CKD-383 0.5/25/1000mg in Healthy Volunteers
This study is a randomized, open-label, single dose, crossover study to evaluate the food effect of CKD-383 in healthy volunteers
- Trial name
- CKD-383 FDI P1 (NCT06695598)
- Testing
- CKD-383
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Weight Management
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
This master study protocol, Study D7260C00015, covers 2 independent, pivotal studies, Study 1 and Study 2. Each study is a global, randomized, double-blind, parallel-group, multicenter, Phase III study to assess the efficacy and…
- Trial name
- Embold (NCT07667803)
- Testing
- Elecoglipron
- Where
- 325 sites in United States, Argentina and 17 more
- Volunteers
- 4,500 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus (T2DM), Non-Alcoholic Fatty Liver Disease (NAFLD)
A Phase 1b Study of QX1206 in T2DM Patients With NAFLD
This is an open label phase 1b trial of QX1206 in patients with T2DM and with NAFLD. Laboratory tests and other measurements will be assessed prior to the first dose of study treatment and throughout the study to determine the…
- Trial name
- NCT06694935
- Testing
- QX1206
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- 1Globe Health Institute
Type 2 Diabetes, Atherosclerosis
The Copenhagen Insulin and Metformin Therapy Trial
Type 2 Diabetes Mellitus patients (T2DM) have an increased mortality rate due to macrovascular disease. The primary objective of the study is to evaluate the effect of an 18-month treatment with metformin versus placebo in…
- Conditions
- Type 2 Diabetes, Atherosclerosis, Arteriosclerosis
- Trial name
- CIMT (NCT00657943)
- Testing
- metformin, insulin detemir, insulin aspart + insulin aspart protamin
- Where
- 9 sites in Denmark
- Volunteers
- 415 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes
A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
This study is a multicenter, randomized, open-label, parallel-group, phase 3 clinical trial aimed at evaluating the efficacy and safety of HDM1005 versus active comparator in subjects with Type 2 Diabetes Mellitus (T2DM)…
- Trial name
- NCT07417306
- Testing
- HDM1005 1, HDM1005 2, Mazdutide
- Where
- China
- Volunteers
- 912 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
T2DM (Type 2 Diabetes Mellitus), Hypogonadism
Efficacy of Androgen Substitution for Hypogonadism in Men With Type 2 Diabetes Mellitus
The purpose of the study is to get data of prevalence of testosterone deficiency in patient with T2DM in Russian Federation
- Trial name
- DESTINY (NCT03437109)
- Testing
- Laboratory tests
- Where
- 2 sites in Russia
- Volunteers
- 554 people
- Sponsor
- Besins Healthcare
Type 2 Diabetes Mellitus, Hypertension
Dose-ranging Study to Evaluate the Effectiveness and Tolerability of MK0736 in Patients With Type 2 Diabetes Mellitus (T2DM) and Hypertension (0736-007)
The study will assess the efficacy and tolerability of MK0736 in patients with Type 2 Diabetes Mellitus and Hypertension who are on ongoing therapy with Angiotensin-Converting Enzyme or Angiotensin Receptor Blocker.
- Trial name
- NCT00806585
- Testing
- MK-0736, Comparator: HCTZ
- Volunteers
- 620 people
- Sponsor
- Merck Sharp & Dohme LLC
Uncontrolled Type 2 Diabetes Mellitus
Effect of CPL-2009-0031 in the Treatment of Patients With Uncontrolled Type 2 Diabetes Mellitus
This trial is a Phase-III, Prospective, Randomized, Double Blind, Parallel Group, Two arm, Comparative, Multicenter, controlled clinical trial to determine the efficacy, safety, and tolerability of oral CPL-2009-0031 140 mg in…
- Trial name
- NCT04801199
- Testing
- CPL-2009-0031 140 mg, Sitagliptin 100mg
- Where
- 12 sites in India
- Volunteers
- 355 people
- Sponsor
- Cadila Pharnmaceuticals
Type 2 Diabetes Mellitus
A Phase 1 Study to Investigate the Mechanism of Action of Ipragliflozin
In this study the effect of ipragliflozin on glucose homeostasis in healthy subjects and T2DM subjects, and the effect of exposure of ipragliflozin on urinary glucose excretion and plasma glucose in T2DM subjects will be…
- Trial name
- NCT01611363
- Testing
- ASP1941
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.