Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/ Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg
An open label, randomized, two-period, two treatment, two-sequence, crossover, balanced, single dose oral bioequivalence study to compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet versus Synjardy XR tablets…
- Trial name
- NCT07694115
- Testing
- Empagliflozin / Metformin Extended-Release Tablet, Synjardy XR tablets
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Type 2 Diabetes Mellitus (T2DM), Psychological Distress
Effectiveness of a Diabetes Self-Management Program Among Ethnic Minority Elderly in Rural Thailand
Type 2 diabetes is a serious health condition that affects many older adults from ethnic minority communities in Northern Thailand.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Psychological Distress, Hyperglycemia
- Trial name
- DSM-EME (NCT07669389)
- Testing
- Diabetes Self-Management Education (DSME) Program, Usual Care
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Taipei Medical University
Diabetic Foot Ulcer, Type 1 Diabetes Mellitus
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
The goal of this investigational study is to evaluate the safety and clinical performance of Tropocells Autologous Platelet-rich Fibrin (PRF) for wound care for both males and females, ages 18-80 years old, with Grade 1 and 2…
- Conditions
- Diabetic Foot Ulcer, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Neuroischemic Foot Ulcer
- Trial name
- NCT06810726
- Testing
- Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Estar Medical dba Medical Technologies, LTD
Diabetes Mellitus, Type 2
Effects of Sitagliptin on Type 2 Diabetes Mellitus Patients on Treatment With Metformin and Insulin
The purpose of the study is to determine the efficacy and safety of sitaglipin in the treatment of Type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control using metformin and insulin.
- Trial name
- NCT01341717
- Testing
- Sitagliptin, Glimepiride, Metformin
- Where
- India
- Volunteers
- 440 people
- Sponsor
- Jothydev's Diabetes and Research Centre
Type 2 Diabetes Mellitus
Tenelia Triple Combination Study
After a screening, a 2-week, single-blind placebo run-in, 200 patients will be randomized in a 1 : 1 ratio to the addition of either once-daily Teneligliptin 20mg or sitagliptin 100mg to ongoing stable doses of glimepiride in…
- Trial name
- TETRIS (NCT02567994)
- Testing
- Teneligliptin
- Where
- South Korea
- Volunteers
- 201 people
- Sponsor
- Handok Inc.
Type 2 Diabetes Mellitus (T2DM)
Combination of Bitter Melon Extract and Snakehead Fish Powder to Reduce Glycaemia in Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, which contributes to the formation of advanced glycation end-products (AGEs) and increases the risk of long-term…
- Trial name
- NCT07303127
- Testing
- Bitter Melon Extract and Snakehead Fish Powder Combination
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Muhammadiyah Surakarta
Type 2 Diabetes Mellitus
Dose-finding of PB-119 Administered Subcutaneously Once-weekly Versus Placebo in Drug-naïve T2DM Subjects
This is a multicenter, randomized, double-blind, placebo-controlled, parallel dose cohort, multiple dose study to evaluate the efficacy, safety, and tolerability of different doses of PB-119 in drug-naïve subjects with T2DM.
- Trial name
- NCT03520972
- Testing
- PB-119 75ug, PB-119 150ug, PB-119 200ug
- Where
- China
- Volunteers
- 251 people
- Sponsor
- PegBio Co., Ltd.
Type 2 Diabetes, Obesity
Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM
This is an exploratory study evaluating CS0159 in combination with Semaglutide in metabolic dysfunction-associated fatty liver disease (MAFLD) patients with obesity and type 2 diabetes (T2DM).
- Conditions
- Type 2 Diabetes, Obesity, Non-alcoholic Fatty Liver Disease
- Trial name
- NCT07570810
- Testing
- CS0159, Semaglutide
- Volunteers
- 30 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes
A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Type 2 Diabetes Mellitus Subjects (T2DM) Treated With Basal + Prandial Insulin
This study will be conducted to compare the efficacy, safety and patient-reported outcome of once-weekly GZR4 and once-daily Insulin Glargine U100 in Combination with Insulin Aspart (with or without Non-Insulin Antidiabetic…
- Trial name
- NCT06767761
- Testing
- GZR4, Insulin Glargine U100 group
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Mortality of Patients with CVD, Mortality of Patients with CVD and T2DM
The Impact of Type 2 Diabetes Mellitus on Cardiovascular Events in Saudi Arabia Now and Future
Cardiovascular disease (CVD) and Type 2 diabetes mellitus (T2DM) are major global health challenges with significant morbidity and mortality. In Saudi Arabia, the prevalence of CVD and T2DM is increasing.
- Conditions
- Mortality of Patients with CVD, Mortality of Patients with CVD and T2DM, Mortality of Patients with T2DM, Mortality of Patients with Neither
- Trial name
- NCT06674161
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
NAFLD - Non-Alcoholic Fatty Liver Disease, Type 2 Diabetes
Hepatic and Cardiac Metabolic Flexibility in Subjects With T2DM With and Without NAFLD
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from simple reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH) and cirrhosis.
- Trial name
- NCT04698486
- Testing
- Hyperinsulinemic euglycaemic clamp
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes (T2DM)
Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes
This study is a multicenter, randomized, open, parallel-controlled, Phase III clinical study aimed to evaluate the efficacy and safety of semaglutide injection and Ozempic® in patients with type 2 diabetes.
- Trial name
- NCT07046273
- Testing
- F027, Ozempic®
- Volunteers
- 496 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes Mellitus (T2DM), Cost-effectiveness, Sulfonylureas, DPP4 Inhibitors, Metformin
Comparative Analysis of Cost-effectiveness Between Sulfonylureas and DPP4 Inhibitors in Combination With Metformin in Treatment of Type 2 Diabetic Patients : A Retrospective, Observational Study.
The aim of this study is to compare the cost effectiveness of Sulfonylureas and DPP4-inhibitors in combination with Metformin among type2 diabetic patients diagnosed for 2-5 years.
- Trial name
- NCT06570980
- Testing
- sulfonylurease with metformin, DPP4 inhibitors with Metformin
- Where
- Bangladesh
- Volunteers
- 200 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Type 2 Diabetes Mellitus
Efficacy and Safety of Combination Therapy of Vildagliptin/Metformin in Patients in Type 2 Diabetes Mellitus (T2DM)
This study will assess the efficacy and safety of combination therapy of vildagliptin/metformin in patients with T2DM inadequately controlled with metformin 1,000 mg/day.
- Trial name
- NCT01196546
- Testing
- vildagliptin/metformin
- Where
- 8 sites in Thailand
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Novartis
Type 2 Diabetes Mellitus
Effects of Mixed Herbs on Blood Glucose and Lipid Profile in T2DM Patients
The aim of this study was to evaluate the effects of mixed herbs as ad-on therapy on blood sugar and lipid profile of patients with established T2DM.
- Trial name
- T2DM (NCT02159846)
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- International Islamic University Malaysia
Type 2 Diabetes (T2DM)
Evaluate the Efficacy and Safety of GZR101-80 Injection in Patients With Type 2 Diabetes
This study will be conducted to evaluate the efficacy and safety of GZR101-80 Injection in patients with type 2 diabetes mellitus inadequately controlled on oral antidiabetic drugs or Basal Insulin.
- Trial name
- NCT07387003
- Testing
- GZR101-80, GZR33 or Insulin degludec/Insulin aspart or Insulin aspart30 (NovoRapid®30)
- Where
- China
- Volunteers
- 345 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Diabetic Retinopathy, Type 2 Diabetes Mellitus
The Relationship Between Advanced Glycation Endproducts and Diabetes
The overall purpose of this COMIRB application is to perform a cross-sectional pilot study to aid in the design of a prospective epidemiologic study for an NIH grant application.
- Trial name
- NCT02662010
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
DigiDiab Evaluation Domiciliary Nursing Care
GlucoTab is a stand-alone software system to support healthcare professionals in the care of patients with diabetes mellitus or newly diagnosed hyperglycaemia who are treated with insulin and/or other glucose-lowering drugs or of…
- Conditions
- Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes, Insulin Requiring
- Trial name
- NCT06616779
- Testing
- GlucoTab, Diabetes Treatment
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Type 2 Diabetes Mellitus (T2DM), Metabolic Dysfunction-Associated Steatotic Liver Disease
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Metabolic Dysfunction-Associated Steatotic Liver Disease, Biological Age
- Trial name
- NCT06984510
- Testing
- Observational
- Where
- China
- Volunteers
- 2,720 people
- Sponsor
- Ningbo No. 1 Hospital