Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Type 2 Diabetes Mellitus (T2DM)
Ayurveda Diet & Lifestyle Protocol for Type 2 Diabetes: A Feasibility Study
This study looked at whether a 12-week Maharishi Ayurveda diet and lifestyle program was practical and acceptable for adults with Type 2 Diabetes.
- Trial name
- AYU-LIFE-T2D (NCT07400276)
- Testing
- Maharishi Ayurveda Lifestyle Program
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Maharishi International University
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes
The goal of this clinical study is to evaluate the efficacy and safety of Berberine Ursodeoxycholate (HTD1801) compared to placebo in patients with type 2 diabetes, inadequately controlled with diet and exercise alone.
- Trial name
- SYMPHONY-1 (NCT06350890)
- Testing
- HTD1801
- Where
- 56 sites in China
- Volunteers
- 408 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Type 2 Diabetes Mellitus
A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM)
Primary Objective: To demonstrate safety of 14-day repeated lixisenatide doses with 3 ascending doses as compared to placebo in pediatric patients with T2DM.
- Trial name
- NCT02803918
- Testing
- Lixisenatide (AVE0010), Basal Insulin, Metformin
- Where
- 11 sites in United States, Mauritius and 4 more
- Volunteers
- 23 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus (T2DM)
Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus
This is a randomized, double-blind, placebo- and active-controlled, multicenter Phase II clinical trial designed to evaluate the efficacy, safety, and pharmacokinetic characteristics of MWN109 tablets in participants with type 2…
- Trial name
- NCT07801820
- Testing
- MWN109 1, MWN109 2, MWN109 3
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Type 2 Diabetes Mellitus (T2DM)
Medical Assistant Health Coaching for Diabetes in Diverse Primary Care Settings
This study is a cluster (clinic level) randomized pragmatic trial to compare the effectiveness of MA Health Coaching (MAC) delivered by non-clinician primary care staff (i.e., MAs) versus usual care (UC) in improving diabetes…
- Trial name
- MAC (NCT02643797)
- Testing
- Medical Assistant Health Coaching
- Where
- United States
- Volunteers
- 602 people
- Sponsor
- Scripps Whittier Diabetes Institute
Type 2 Diabetes Mellitus With Metabolic Syndrome
CHM for T2DM & MetS
This is a single-arm design. A total of 15 Type 2 Diabetes Mellitus (T2DM) patients with comorbid Metabolic Syndrome (MetS) will be recruited from community.
- Trial name
- NCT06450652
- Testing
- Chinese Herbal Medicine granules
- Volunteers
- 15 people
- Sponsor
- Hong Kong Baptist University
Perinatal and Neonatal Outcomes in Pregnancies With Type 2 Diabetes Mellitus (T2DM)
Antenatal Myo-inositol Supplementation in Pre-existing Diabetes
This feasibility pilot study aims to gather data that can guide the design of a larger, more comprehensive trial to establish the effects of myo-inositol supplementation on supporting healthy outcomes in pregnancies complicated…
- Trial name
- AMulet (NCT07241221)
- Testing
- Myo-inositol and folic acid supplement, Folic acid supplement
- Where
- Singapore
- Volunteers
- 182 people
- Sponsor
- National University Hospital, Singapore
Type 2 Diabetes, Non Celiac Gluten Sensitivity
Evaluation of the Effects of Gluten Free Diet on Clinical Symptoms and Glycemic Index in Type 2 Diabetic Patients With Non-celiac Gluten Sensitivity
Confirmed cases of type 2 diabetes who have presented with gastrointestinal symptoms and have no diagnosed gastrointestinal diseases will be referred to the laboratory for testing of tTG IgA and total IgA antibodies to rule out…
- Trial name
- NCT06900946
- Testing
- gluten, cornstarch
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- National Nutrition and Food Technology Institute
Type 2 Diabetes
The Role of Amylin and Incretins on Postprandial Metabolisms in Adolescents With Type 2 Diabetes Mellitus (T2DM).
To study postprandial metabolism in lean, obese and T2DM adolescents using a mixed meal challenge. Specifically we will be measuring the following parameters of postprandial metabolism: 1.
- Trial name
- NCT00361946
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Type 2 Diabetes Mellitus
A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With Type 2 Diabetes Mellitus
The purpose of this study is to examine the effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants with Type 2 Diabetes Mellitus.
- Trial name
- IRAK4 (NCT07433062)
- Testing
- AZD6793
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus (T2DM)
CGM for Insulin-Treated T2DM During Post-Discharge Transition
The transition from inpatient care to the home setting is a critical phase for glycemic management, often associated with decreased adherence and deterioration of glycemic control.
- Trial name
- TRANSIT-CGM (NCT07414277)
- Testing
- RT-CGM, SMBG
- Where
- 4 sites in China
- Volunteers
- 160 people
- Sponsor
- Shanghai 6th People's Hospital
Carpal Tunnel Syndrome (CTS), Type 2 Diabetes Mellitus (T2DM)
The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes
Our study was planned as a prospective observational study aiming to compare the post-intervention recovery process between patients with carpal tunnel syndrome (CTS) and diabetes mellitus and patients with idiopathic carpal…
- Trial name
- NCT07433257
- Testing
- 1 mL 40 mg [40 mg/mL] triamcinolone acetonide + 1 mL 2% lidocaine hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Diabete Mellitus, Type 2 Diabetes
Mangosteen Supplement as Adjuvant Therapy With Sitagliptin/Metformin in Iraqi Patients With Type 2 Diabetes
This clinical trial was conducted at the National Diabetes Center for Treatment and Research, Mustansiriyah University, Baghdad (Sept 2024-May 2025).
- Conditions
- Diabete Mellitus, Type 2 Diabetes, Obesity Type 2 Diabetes Mellitus, Dyslipidemia in Patients With Diabetes Mellitus
- Trial name
- NCT07172269
- Testing
- Sitagliptin + Metformin, mangosteen supplement, Lifestyle Management
- Where
- Iraq
- Volunteers
- 58 people
- Sponsor
- Mais Qais Hbeeb
Diabetes Mellitus, Type 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of JNJ-38431055 in Volunteers With Type 2 Diabetes Mellitus
This study will assess the safety, tolerability, pharmacokinetics (explores what the body does to the drug), and pharmacodynamics (explores what a drug does to the body) of multiple doses of JNJ-38431055 in volunteers with type 2…
- Trial name
- NCT00946972
- Volunteers
- 33 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity, Morbid, Type 2 Diabetes Mellitus (T2DM)
Comparative Outcomes of One-Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass As Revisional Procedures Following Failed Restrictive Bariatric Surgery
Study Description This prospective, multicenter study aims to compare the outcomes of One-Anastomosis Gastric Bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) as revisional procedures for patients experiencing insufficient…
- Conditions
- Obesity, Morbid, Type 2 Diabetes Mellitus (T2DM), Hypertension, Dyslipidemia
- Trial name
- COBRA stady (NCT06794892)
- Where
- Italy
- Volunteers
- 328 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Type 2 Diabetes Mellitus
PK Study of Dapagliflozin in Pediatric Subjects With T2DM
The primary purpose of this study is to evaluate the pharmacokinetics (PK) of Dapagliflozin in pediatric subjects with type 2 diabetes mellitus (T2DM)
- Trial name
- NCT01525238
- Testing
- Dapagliflozin
- Where
- 17 sites in United States, Mexico
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus, Obesity
DECREASE: Dapagliflozin Plus Exenatide on Central REgulation of Appetite in diabeteS typE 2
This is a 16 week, phase 4, randomized and placebo controlled trial, investigating the separate and combined effects of Sodium Glucose coTransporter 2 (SGLT2) inhibition with dapagliflozin and Glucagon Like peptide-1 (GLP-1)…
- Trial name
- DECREASE (NCT03361098)
- Testing
- Dapagliflozin 10mg, Exenatide
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Amsterdam UMC, location VUmc
Type 2 Diabetes
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)
The main reason for this study is to compare the study drug tirzepatide to insulin glargine in participants with type 2 diabetes on metformin with or without a sulfonylurea.
- Trial name
- NCT04093752
- Testing
- Tirzepatide, Insulin Glargine
- Where
- 67 sites in Australia, China and 2 more
- Volunteers
- 917 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus (T2DM), Semaglutide
The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Semaglutide, Caloric Restriction
- Trial name
- NCT07272343
- Testing
- semaglutide, caloric restriction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Diabetes Mellitus Type 2
Study of Duodenal Mucosal RF Vapor Ablation in Subjects With Type-2 Diabetes Mellitus
The purpose of this clinical study is to test the hypothesis that RF vapor ablation of the duodenal mucosa will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation).
- Trial name
- STEAM T-2DM (NCT05887635)
- Testing
- RF Vapor Ablation
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Aqua Medical, Inc.