Clinical trials: Diabetes Mellitus Type II,
Hypertension, Diabetes
Genetics of Type 2 Diabetes in West Africans
Background: Type 2 diabetes (T2D) and associated complications are major contributors to the global disease burden. T2D is already a major health threat in populations in developed countries and is rapidly taking hold in the…
- Trial name
- NCT00837122
- Where
- 5 sites in Ghana, Nigeria
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cardiovascular Diseases, Type 2 Diabetes Mellitus
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
Type two diabetes mellitus (T2DM) is a common, long term metabolic disorder characterised by hyperglycaemia (high blood glucose) resulting from insulin resistance and relative insulin insufficiency.
- Trial name
- DEFINE (NCT03449251)
- Testing
- Apelin, Relaxin, Normal saline
- Where
- United Kingdom
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type II Diabetes
Determination of the Optimum Cut-off Value of Type 2 Diabetes Diagnosis Among Chinese Population(SENSIBLE STUDY II)
Study of the correlation between AGEsP and HbA1c and diabetic retinopathy prevalence: determination of cut-off value of AGEsP and HbA1c in type 2 diabetes diagnosis in China
- Trial name
- NCT03024788
- Testing
- syringe, fundus camera etc
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Cardiovascular Diseases
EVOC - EVs in Obesity and Cardiometabolic Disease
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart…
- Trial name
- EVOC (NCT06408961)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus Maturity Onset
Smartguard Use in Real Life : a Longitudinal Study in Patients With Type 1 Diabetes
The reference treatment of the type 1 diabetes is intensified insulin therapy by insulin pump. The CGM (continuous glucose monitoring) is a technology available for a decade, which allows the continuous measure of interstitial…
- Trial name
- Smartguard (NCT03047486)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Diabetes, Diabetes Mellitus, Type 1
A Non-interventional, Post Marketing Surveillance (PMS) Study of Tresiba® (Insulin Degludec) to Evaluate Long Term Safety and Efficacy in Patients With Diabetes Mellitus in Routine Clinical Practice in India
This study is conducted in Asia. The aim of the study is to evaluate long term safety and efficacy of Tresiba® (insulin degludec) in patients with diabetes mellitus in routine clinical practice in India.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02117622
- Testing
- insulin degludec
- Where
- 38 sites in India
- Volunteers
- 1,056 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus (T2DM)
Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy
This is a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of 24 once-weekly subcutaneous doses of PB-119 to subjects with type 2 diabetes mellitus (T2DM) not well-controlled by metformin…
- Trial name
- NCT04504396
- Testing
- GLP-1 receptor agonist
- Where
- China
- Volunteers
- 620 people
- Sponsor
- PegBio Co., Ltd.
Diabetes, Diabetes Mellitus, Type 2
Safety and Efficacy of Insulin Detemir in Combination With OADs in Type 2 Diabetes
This trial is conducted in Asia. The aim of this trial is to evaluate the blood glucose achieved with insulin detemir as add-on to current oral antidiabetic drug (OAD) treatment in subjects with type 2 diabetes.
- Trial name
- NCT00592527
- Testing
- insulin detemir
- Where
- 5 sites in India
- Volunteers
- 132 people
- Sponsor
- Novo Nordisk A/S
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus, Type 2
Resistance Training in Diabetic Elder Patients
The purpose of this study is to investigate the effect of a 12-week progressive resistance training program on the skeletal muscle function, glycemic control, functional capacity, and quality of life in the elderly with type 2…
- Trial name
- NCT01638351
- Testing
- Resistance exercise, Usual care
- Where
- Taiwan
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus
Measurement Algorithm Control and Optimization With Subsequent Performance Evaluation of Sanmina Non-invasive Biosensors During a Standardized Meal Test in Patients With Diabetes Mellitus Type 1 and Type 2
Measurement algorithm control and optimization with subsequent performance evaluation of Sanmina biosensors in monitoring of glucose, heart rate (HR), and SpO2 in patients with type 1 and type 2 diabetes during a standardized…
- Trial name
- NCT04379427
- Testing
- Sanmina Biosensor
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sciema UG
Diabetes Mellitus, Diabetic Retinopathy
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Nerve Injury
- Trial name
- NCT03970161
- Testing
- routine ophthalmic examination
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 2 Diabetes
Oral Insulin: A Comparison With Subcutaneous Regular Human Insulin in Patients With Type 2 Diabetes
This study compared the pharmacokinetic and pharmacodynamic properties of an oral insulin formulation with that of a standard subcutaneous injection of regular human insulin.
- Trial name
- NCT00982254
- Testing
- Oral insulin, regular human insulin
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Obesity
Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients
Obesity is a multifactorial disease that affects millions of people worldwide. It is the main independent risk factor for developing type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00873405
- Testing
- Silastic® ring sleeve gastrectomy, Silastic® ring gastric bypass
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Federal University of Espirito Santo
Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus
Fat Around Heart Arteries as a Measure of Inflammation in Patients With Glycometabolic Disease
In this study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart.
- Conditions
- Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus, Type 2 Diabetes (T2DM), Prediabetes
- Trial name
- PCAT-GMD (NCT07144670)
- Where
- Denmark
- Volunteers
- 747 people
- Sponsor
- Odense University Hospital
Type 2 Diabetes
Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects.
This study is a randomized, open-label, single-dose, parallel-controlled biosimilar comparison study comparing the pharmacokinetics, safety and immunogenicity of the investigational drug and the active comparator in healthy adult…
- Trial name
- NCT06634927
- Testing
- Ozempic®, HDG1901
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Diabetes Mellitus Type 2, Diastolic Dysfunction
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
The purpose of this study is to determine whether liraglutide a GLP-1 analogue are effective in the treatment of diastolic dysfunction in type 2 diabetes patients analyzed by cardiac MRI.
- Conditions
- Diabetes Mellitus Type 2, Diastolic Dysfunction, Cardiac MRI, Myocardial Perfusion
- Trial name
- NCT02655770
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetes Mellitus, Type 2
The FreeStyle Libre Enabled Reduction of A1c Through Effective Eating and Exercise Study
This two-year multisite, real-world, before-after prospective six-month pilot study utilizing a single-group cohort design (n=184) which will first occur in London, Ontario (n=92) through the St.
- Trial name
- LIBERATE (NCT05261906)
- Testing
- LIBERATE
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Western University, Canada
Diabetes Mellitus
Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes
This study was designed to reproduce candidate single nucleotide variants found by whole exome sequencing in some type 2 diabetic patients dependent on sulfonylurea in a separate patient group.
- Trial name
- NCT04123587
- Testing
- discontinuation of Sulfonylureas
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Nurse's Role, Diabetes Mellitus, Type 2
EFFECT OF DIABETES NURSE COACHING ON DIABETES
American Diabetes Association and American Clinical Endocrinology American Association of Clinical Endocrinologists, treatment and care of individuals with diabetes in achieving their goals; regulation of nutrition, regulation of…
- Trial name
- NCT05870293
- Testing
- nurse coaching
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Tuğba Bilgehan
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