Clinical trials: Diabetes Mellitus Type II,
Type 2 Diabetes
A Study to Evaluate ITCA 650 Compared to Sitagliptin for the Treatment of Type 2 Diabetes
Phase 3 study to compare treatment with ITCA 650 to sitagliptin when added to metformin monotherapy in patients with type 2 diabetes.
- Trial name
- NCT01455909
- Testing
- ITCA 650 60 mcg/day, sitagliptin
- Where
- United States
- Sponsor
- Intarcia Therapeutics
Type 2 Diabetes, Cardiovascular Complication
Study on the Predictive Value of High-sensitivity Cardiac Troponin I, N-terminal Pro-B-natriuretic Peptide, and Soluble Suppression of Tumorigenesis-2 for Mortality and the Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV)
The Diabetes-CV study is an observational study designed to assess the prognostic value of serum cardiac damage markers high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B-natriuretic peptide (NT-proBNP), and soluble…
- Trial name
- Diabetes-CV (NCT06902857)
- Where
- Italy
- Volunteers
- 964 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Type 2 Diabetes Mellitus
Randomized, Double-blind, Active-controlled, Study of Rivoglitazone in Type 2 Diabetes Mellitus
This is a 26-week, multicenter, randomized, double-blind, placebo and active comparator-controlled, parallel-group study in participants with type 2 diabetes currently sub-optimally controlled by diet and exercise or with…
- Trial name
- NCT00571519
- Testing
- Rivoglitazone HCl, pioglitazone HCl, pioglitazone HCl 45 mg
- Where
- 18 sites in United States
- Volunteers
- 94 people
- Sponsor
- Daiichi Sankyo
Diabetes Mellitus, Type 2, Hypertension
Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities
This study is to assess the safety and performance of the Neurotronic Infusion Catheter and ethanol denervation of renal and hepatic arteries for the treatment of patients with Type 2 Diabetes (T2DM), Hypertension and Obesity.
- Trial name
- NECTAR IV (NCT05369065)
- Testing
- Ablation Treatment, Arterial Angiography Only, Single Arm non-Randomized Ablation Treatment
- Where
- 3 sites in Georgia
- Volunteers
- 60 people
- Sponsor
- Neurotronic, Inc.
Diabetes Mellitus, Type 2
Prediction of the SEPRA Diabetes Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT05577728
- Testing
- New use of semaglutide injection, New initiation of "standard of care" (SGL2i, 2nd generation SU, DPP-4i and GLP-1 RA except for semaglutide inj or oral)
- Where
- United States
- Volunteers
- 2,316 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2
In-patient Study With GSK716155 In Patients With Type 2 Diabetes Mellitus
This study is a placebo-controlled study in patients with Type 2 Diabetes Mellitus to assess safety and tolerability parameters, the levels of GSK716155 in the bloodstream when it is given at the same dose 7 days apart, and the…
- Trial name
- NCT00354536
- Testing
- GSK716155 subcutaneous injections
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Heart Diseases
Heritage Study--Genetics, Exercise and Risk Factors
To document the role of the genotype in the cardiovascular and metabolic responses to aerobic exercise-training and the contribution of inherited factors in the changes brought about by regular exercise for several cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent, Diabetes Mellitus
- Trial name
- HERITAGE (NCT00005137)
- Testing
- exercise program
- Sponsor
- Washington University School of Medicine
Diabetes, Diabetes Mellitus, Type 2
Effect of Liraglutide as add-on to Metformin Compared to Either Liraglutide or Metformin Alone, or to a Combination of Metformin and a SU (Sulphonylurea) Agent in Subjects With Type 2 Diabetes
This trial is conducted in Europe and Oceania. The aim of this trial is to assess the effect on glycemic control of NNC 90-1170 (liraglutide) added to metformin compared to metformin given alone in subjects with type 2 diabetes…
- Trial name
- NCT01511172
- Testing
- liraglutide, metformin, glimepiride
- Where
- 41 sites in Australia, Austria and 6 more
- Volunteers
- 145 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Diseases, Type 2 Diabetes
Continuous Glucose Monitoring to Assess Glycemia in Chronic Kidney Disease - Changing Glucose Management
The goal of this study is to test whether a dipeptidyl peptidase-4 inhibitor, compared with a sulfonylurea, improves time in normal blood glucose range and reduces blood glucose variability.
- Trial name
- CANDY-CANE (NCT02608177)
- Testing
- Linagliptin, Glipizide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Washington
Diabetes, Diabetes Type 2
Glucose, Understanding, Integrated Digital Health, and Engagement (GUIDE) Study
The purpose of this study is to evaluate whether an Integrated Digital Health (IDH) intervention with and without healthcare provider engagement, improves glycemic control and diabetes-related outcomes among adults with Type 2…
- Trial name
- GUIDE (NCT07689877)
- Testing
- Integrated Digital Health (IDH) platform, Provider engagement
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 2
Tulip Study: Testing the Usefulness of Lantus When Initiated Prematurely In Patients With Type 2 Diabetes
Primary objective: The primary objective of this trial is: To evaluate the efficacy of initiating Lantus in combination with oral antidiabetics drugs compared to oral antidiabetic treatment optimised by enhancing hygienic and…
- Trial name
- NCT00174681
- Testing
- Insulin Glargine
- Where
- 6 sites in Croatia, Czechia and 4 more
- Volunteers
- 390 people
- Sponsor
- Sanofi
Type 2 Diabetes
A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin
This study is a multicenter, randomized, double-blind (with open-label dose levels and active comparator), parallel-group, placebo- and active-controlled Phase 2 clinical trial aimed at evaluating the efficacy, safety…
- Trial name
- NCT07109700
- Testing
- HDM1005 1, HDM1005 2, HDM1005 3
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2
Efficacy and Safety of BI 10773 in Combination With Insulin in Patients With Type 2 Diabetes
The objective of the current study is to investigate the efficacy, safety and tolerability of BI 10773 at two different doses compared to placebo during long term treatment (78 weeks) in combination with basal insulin in patients…
- Trial name
- NCT01011868
- Testing
- BI 10773 low dose, BI 10773 high dose
- Where
- 99 sites in United States, Denmark and 5 more
- Volunteers
- 494 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
Basal Insulin for Type 2 Diabetes Patients Treated in Outpatient Clalit Clinics
Treatment of diabetes mellitus type II with basal insulin, for patients treated in Clalit outpatient clinics that are not adequately controlled with current treatment.
- Trial name
- Lapas II (NCT00726674)
- Where
- Israel
- Volunteers
- 1,229 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Type 2 Diabetes
Roflumilast Plus Alogliptin Proof-of-Mechanism Study in Type2 Diabetes
The purpose of this study is to assess the effect of roflumilast plus alogliptin on glucagon-like peptide-1 (GLP-1) and glucose levels in patients with type 2 diabetes.
- Trial name
- NCT01664624
- Testing
- Roflumilast, Alogliptin, Exenatide
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2, Hemodialysis
Efficacy and Tolerance of Liraglutide for Weight Loss in Obese Type 2 Diabetic Hemodialysis Patients
Diabetes is the second leading cause of end stage renal disease in France (22% in the 2016 REIN register). In hemodialysis, its prevalence is higher, between 30-40% depending on the study.
- Conditions
- Diabetes Mellitus, Type 2, Hemodialysis, Obese
- Trial name
- LIRADIAL (NCT04529278)
- Testing
- Liraglutide
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Type 2 Diabetes
Evaluating the Effect of a Diabetes Health Coach in Individuals With Type 2 Diabetes
Background: Health coaching is defined as health education, promotion and support by a professional to enhance the well-being of individuals and facilitate the achievement of their health-related goals.
- Trial name
- DiabCoach (NCT02128815)
- Testing
- Coaching
- Where
- 2 sites in Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus
Cholesterol Metabolism and Lipid Transfer in Diabetes
The diabetic dyslipidemia is one of the most important risk factor in the development of coronary artery disease. The low density lipoprotein (LDL)-like nanoemulsions is being used to study the clearance of cholesteryl ester and…
- Trial name
- NCT01010035
- Testing
- Plasma kinetic study
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type 2 Diabetes
Degludec Glargine U300 Hospital Study
Limited data exist about the use of insulin degludec and insulin glargine U300 in the hospitalized patients. A previous study compared the safety and efficacy of insulin degludec versus insulin glargine U100 for the management of…
- Trial name
- NCT05036876
- Testing
- Degludec, Glargine U300
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Medanta, The Medicity, India
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