Clinical trials: Diabetes Related Complications
Gastric Retention
Impact of Neuropathy on the Risk of Semaglutide-Induced Gastric Retention
A prospective, single-center, observational study to compare the risk of gastric retention between the exposure group (with neuropathy) and non-exposure group (without neuropathy) in diabetic patients receiving uninterrupted…
- Trial name
- NCT07156591
- Testing
- Esophagogastroduodenoscopy
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Fudan University
Diabetic Polyneuropathy
Peripheral Nerve Stimulation in Diabetic Patients
The prevalence of diabetes mellitus (DM) in industrialized countries is estimated to be about 7.3% and its incidence has been growing in recent years.
- Trial name
- NCT01488474
- Testing
- peripheral nerve stimulation
- Where
- Austria
- Volunteers
- 124 people
- Sponsor
- Medical University of Graz
Diabetes, Renal Failure , Chronic
Implementation Trial In patieNts With rEnal failuRe and diAbetes for Major Adverse reNal and Cardiovascular Events
The goal of this clinical study is to establish if the use of public health-related messages, designed and disseminated to a targeted population, will result in tangible improvements in patient outcomes and healthcare practices.
- Trial name
- ITINERANCE (NCT07634718)
- Testing
- Health-related messages
- Where
- France
- Volunteers
- 125,000 people
- Sponsor
- Nantes University Hospital
Diabetic Neuropathy, Painful
Study With Two Capsaicin Topic Treatments in Diabetic Neuropathy.
Clinical trial of "line extension" of drug ARAFARMADOL® 0.075% cream in a new formulation in topical solution applicable in roll-on and with the same therapeutic indications approved for the cream.
- Trial name
- NCT05029297
- Testing
- Capsaicin
- Volunteers
- 161 people
- Sponsor
- Arafarma Group, S.A.
Diabetic Retinopathy
Integrating DR Into Mainstream Health System in Bangladesh
Diabetes mellitus is a leading cause of death and disability. Diabetic Retinopathy (DR) is an eye disease that affects the eyesight of about 21.3% persons with diabetes in Bangladesh in a way that is irreversible because of the…
- Trial name
- NCT03658980
- Testing
- Health Education Intervention
- Where
- Bangladesh
- Volunteers
- 299 people
- Sponsor
- Hiroshima University
Negative-Pressure Wound Therapy, Diabetic Foot
Comparison Between Negative Pressure Wound Therapy and Conventional Wound Dressings Before and After Split-Thickness Skin Grafting in Diabetic Foot Wounds
The aim of this thesis is to compare the efficacy of Vacuum assisted closure device versus conventional dressing before and after split thickness skin grafting in diabetic foot wounds.
- Trial name
- NCT05716503
- Testing
- Negative Pressure Wound Therapy (NPWT), Ordinary dressings with antibiotic ointment and gauze
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Diabetic Nephropathy
Nephropathy In Type 2 Diabetes and Cardio-renal Events
The NID-2 study, a multicentric study (21 centres enrolled), was planned in two phases: Phase 1(observational study, completed in September 2005): after the identification of a type-2 diabetic population with typical Diabetic…
- Trial name
- NID-2 (NCT00535925)
- Testing
- SoC therapy, irbesartan, ramipril
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 2 Diabetes Mellitus
A Cohort Study of Incretin-based Therapy Combined With Insulin in Type 2 Diabetic Patients for 5 Years
The use of dipeptidyl-peptidase 4 (DPP-4) inhibitors and glucagon like peptide 1 (GLP1) analogues for the treatment of diabetic mellitus (DM) type 2 is growing (1,2).
- Trial name
- NCT01681550
- Testing
- Incretin-based therapy
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Nagaoka Red Cross Hospital
Ketosis Prone Diabetes
Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
- Trial name
- NCT06699810
- Testing
- Continuous Glucose Monitoring, Insulin
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Diabetic Retinopathy
Using Calcium Dobesilate to Treat Chinese Patients With Mild to Moderate Non-proliferative Diabetic Retinopathy
Calcium dobesilate has been recommended to treat diabetic retinopathy due to its potential in protecting against retinal vascular damage.
- Trial name
- CALM-DR (NCT04283162)
- Testing
- Calcium Dobesilate, conventional treatment
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zhongda Hospital
Small Vessel Disease of Diabetes Mellitus
Validating Imaging Biomarkers of Small Vessel Disease in Diabetic Individuals Using Advanced MRI Techniques.
To develop a set of biomarkers for imaging of small vessel disease in diabetic individuals using advanced MRI techniques. With this the investigators want to document progression of disease both radiologically and clinically.
- Trial name
- NCT03754608
- Testing
- MRI including cf-MRI, DTI, ASL and CVR.
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetic Retinopathy, Vitreomacular Traction
Methotrexate Infusion and Intrasilicone Injection During Diabetic Vitrectomy
The goal of this interventional clinical trial is to assess anatomical and functional outcomes of methotrexate use in irrigating fluid during parsplana vitrectomy combined with intrasilicone injection at end of surgery in…
- Trial name
- NCT06038968
- Testing
- Methotrexate 25 MG/ML, parsplana vitrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Diabetic Foot Ulcer
Plantar Pressure Distribution in Diabetic Foot Ulcer
The goal of this clinical trial is to find out the changes in peak pressure and pressure-time integral after twelve weeks from the initial utility of foot insoles and eight weeks later as a follow-up in diabetic foot ulcers.
- Trial name
- PPDDFU (NCT05888259)
- Testing
- foot insole
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus, Glaucoma
Smartphone Screening for Eye Diseases
To validate new screening instruments for eye disease, increase eye care access in underserved communities, and provide a scientifically implemented method to set up programs for eye disease screening.
- Conditions
- Diabetes Mellitus, Glaucoma, Age Related Macular Degeneration, ROP
- Trial name
- NCT03076697
- Testing
- Fundus photography
- Volunteers
- 472 people
- Sponsor
- University of Michigan
Diabetic Foot
Clinical Trial for the Treatment of Diabetic Foot Ulcers Using a Nitric Oxide Releasing Patch: PATHON
Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences.
- Trial name
- NCT00428727
- Testing
- Controlled nitric oxide releasing patch
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Lower Extremity or Diabetic Foot Ulcers, Bacterial Infection
Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm
This is a prospective study of Veterans with chronic lower extremity or diabetic foot ulcers who will be randomized to either a Larval Debridement Therapy group (Biobags every 4 days x 2 applications) or a Sharp Debridement…
- Trial name
- NCT02294175
- Testing
- Larval Debridement Therapy, Bedside Sharp Debridement
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- North Florida Foundation for Research and Education
Healthy
A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects
The goals of this study are to evaluate the safety and tolerability of multiple ascending doses of PF-04634817 administered orally to healthy adult subjects.
- Trial name
- NCT01140672
- Testing
- PF-04634817
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Pfizer
Metabolomics, Obesity
Metabolomic Profiling in Adolescents With Obesity and Diabetes
The purpose of this study is to identify unique metabolite signatures associated with the development of Type 2 diabetes and diabetic kidney disease in children.
- Conditions
- Metabolomics, Obesity, Diabetes, Diabetic Nephropathies
- Trial name
- NCT02145572
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Diabetic Foot Ulcer Healing Trajectories
Efficacy of Negative Pressure Wound Therapy Versus Conventional Moist Dressings on Diabetic Foot Ulcer Healing Trajectories
Background: Diabetic foot ulcers (DFUs) are severe, chronic complications of diabetes carrying a high risk of amputation. While Negative Pressure Wound Therapy (NPWT) is an active biophysical treatment, clinical evidence using…
- Trial name
- DF-WOUND-RCT (NCT07745075)
- Testing
- Vacuum-Assisted Closure (VAC / NPWT)
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jerash Private University
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