Clinical trials: Diabetes Related Complications
Diabetic Foot, Foot Ulcer; Diabetic
Study of Amniotic Membrane Graft in the Management of Diabetic Foot Ulcers
This is comparison trial comparing human amniotic membrane to standard wound care for non healing diabetic foot wounds over a 12 weeks period
- Trial name
- NCT02399826
- Testing
- Offloading, Dressing Application
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lower Extremity Institute for Research and Therapy
Diabetes, Diabetic Foot Ulcer
Multiple Applications of ExpressGraft-C9T1 Skin Tissue as a Treatment for Diabetic Foot Ulcers
Some people with diabetes get foot ulcers that do not heal. These ulcers can get infected and cause other medical problems. Five patients with these foot ulcers volunteered to participate in the first part of this study…
- Conditions
- Diabetes, Diabetic Foot Ulcer, Non-healing Wound
- Trial name
- NCT04134143
- Testing
- ExpressGraft-C9T1 Skin Tissue
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Diabetic Foot, Peripheral Neuropathy With Type 2 Diabetes
The Effects of Different Exercises on Tissue Mechanics, Strength and Neuropathy Symptoms in Type 2 Diabetes Patients
To examine the effects of aerobic exercise and foot exercises in addition to aerobic exercise on lower extremity distal tissue mechanics, muscle strength and neuropathy symptoms in type 2 diabetics with peripheral neuropathy.
- Trial name
- NCT05422235
- Testing
- Routine Medical Treatment, Aerobic Exercise, Aerobic Exercise+ Foot-Related Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Diabetic Neuropathy
Study of DA-9801 to Treat Diabetic Neuropathy
To evaluate the effectiveness of DA-9801 at 300mg, 600mg, 900mg and placebo, in reducing pain in subjects with diabetic neuropathic pain compared to their baseline values.
- Trial name
- NCT01822925
- Testing
- DA-9801 300mg, DA-9801 600mg, DA-9801 900mg
- Where
- 14 sites in United States
- Volunteers
- 128 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Diabetic Retinopathy, Neurodegeneration
Retinal Neurodegenerative and Vascular Changes in Diabetic Patients
Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with…
- Trial name
- NCT04637217
- Testing
- Optical Coherence Tomography
- Where
- Romania
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Type 2 Diabetes, Obesity
Randomisation to Endobarrier Alone Versus With Incretin Analogue in SustainEd Diabesity (REVISE-Diabesity)
New effective non-surgical treatments are needed for patients whose obesity and type 2 diabetes (T2DM) do not respond to current medical therapies.
- Conditions
- Type 2 Diabetes, Obesity, Diabesity
- Trial name
- NCT02055014
- Testing
- Liraglutide, Duodenal-jejunal bypass liner - Endobarrier device
- Where
- 4 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Diabetes, Diabetic Foot
Optimized Care of People With Diabetes and Foot Complication in Primary Care
The goal of this observational study is to create and evaluate and new management, by using eHealth tools, to prevent diabetic foot ulcers. The main questions it aims to answer are: 1. Validation a.
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Diabetes Mellitus, Type 2
- Trial name
- NCT05692778
- Testing
- Patients being foot examined by using an eHealth tool, Patients being foot examined in traditional manner
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Sahlgrenska University Hospital
Pain, Diabetic Neuropathies
A Phase 2 Study of Tapentadol Extended-Release (JNS024ER) ) in Japanese Participants With Chronic Pain Due to Diabetic Neuropathic Pain or Postherpetic Neuralgia
The purpose of this study is to investigate the efficacy and safety of tapentadol extended-release (ER) tablets in Japanese participants with moderate to severe chronic (lasting a long time) pain due to painful diabetic…
- Conditions
- Pain, Diabetic Neuropathies, Neuralgia, Postherpetic Neuralgia
- Trial name
- NCT01124617
- Testing
- Tapentadol
- Where
- 31 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.
Diabetic Foot Ulcer, Wound
Investigation of the Effects of Different Exercise on Wound Healing in Patients wıth Diabetic Foot Wounds
Diabetic foot ulcers are a common complication of diabetes mellitus and are associated with delayed wound healing, impaired quality of life, and an increased risk of lower extremity amputation.
- Trial name
- NCT05422846
- Testing
- standard treatment, aerobic exercise, exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Harran University
Diabetic Foot Ulcer
Study of Oasis Ultra in Diabetic Foot Ulcers
Many people with diabetes will develop a non-healing diabetic foot ulcer. Many ways are available to try to get a diabetic foot ulcer to heal, including application of Oasis Ultra.
- Trial name
- NCT01835379
- Testing
- Oasis, Standard
- Where
- 16 sites in United States
- Volunteers
- 82 people
- Sponsor
- Healthpoint
Non-healing Wound, Diabetic Foot Ulcer
Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound…
- Trial name
- NCT06028386
- Testing
- AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Arch Therapeutics
Hyperglycaemic Crisis in Diabetes Mellitus, Diabetic Ketoacidosis
Concurrent Subcutaneous Basal Insulin and Intravenous Insulin Pump in Hyperglycemic Crisis Patients Under Critical Care
The safety and efficacy of basal insulin during intravenous insulin infusion for hyperglycemic crisis patients under critical care is still unknown.
- Conditions
- Hyperglycaemic Crisis in Diabetes Mellitus, Diabetic Ketoacidosis, Hyperglycaemic Hyperosmolar Nonketotic Syndrome
- Trial name
- NCT05155917
- Testing
- Insulin Glargine 300 UNT/ML [Toujeo]
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Changhua Christian Hospital
Peripheral Vascular Disease, Diabetic Foot Ulcer
Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently?
The goal of this multicenter, multi-national, multi-arm, multi-stage, randomized controlled trial, is to determine the added benefit of hyperbaric oxygen treatment (HBOT) in patients with diabetic foot ulcers and peripheral…
- Conditions
- Peripheral Vascular Disease, Diabetic Foot Ulcer, Amputation
- Trial name
- DIONYSIUS (NCT05804097)
- Testing
- Hyperbaric oxygen
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetic Foot, Mobile Application, Patient Education
Mobile Application For Educating Diabetics About Foot Care
Purpose: Our aim was to develop a training program on the mobile application and to assess the effect of this training on the participants' knowledge about foot care, their self-efficacy and their behavior levels.
- Trial name
- NCT04265469
- Testing
- Diabetic foot education
- Volunteers
- 130 people
- Sponsor
- Istanbul Medeniyet University
Diabetes Mellitus, Diabetic Foot Ulcer
Contribution of Psychological Factors in the Healing of the Diabetic Foot Ulcer
Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes and can lead to amputations in 85% of cases, resulting in physical, psychological, family, social and economic consequences.
- Trial name
- NCT04698720
- Testing
- Muscle Relaxation with Guided Imagery, Hypnosis with Guided Imagery, Neutral Guided Imagery
- Where
- 3 sites in Portugal
- Volunteers
- 69 people
- Sponsor
- University of Minho
Foot Ulcer, Diabetic Foot
A Study on the Efficacy and Safety of Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers With REGRANEX
The purpose of this study is to evaluate the efficacy and safety of REGRANEX® Gel compared with placebo when applied for up to 52 consecutive weeks to recurring or non-healing ulcers of the ankle or foot related to diabetes.
- Conditions
- Foot Ulcer, Diabetic Foot, Skin Ulcer, Diabetic Neuropathies
- Trial name
- NCT00034788
- Testing
- Becaplermin
- Volunteers
- 84 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Small Vessel Disease of Diabetes Mellitus
Validating Imaging Biomarkers of Small Vessel Disease in Diabetic Individuals Using Advanced MRI Techniques.
To develop a set of biomarkers for imaging of small vessel disease in diabetic individuals using advanced MRI techniques. With this the investigators want to document progression of disease both radiologically and clinically.
- Trial name
- NCT03754608
- Testing
- MRI including cf-MRI, DTI, ASL and CVR.
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Type 2, Urosepsis
Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes
The purpose of this study is to compare the risk of serious adverse events associated with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in comparison with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors among…
- Conditions
- Diabetes Mellitus, Type 2, Urosepsis, Diabetic Ketoacidosis, Lower Extremity Amputation
- Trial name
- NCT04017221
- Testing
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors, Dipeptidyl peptidase-4 (DPP-4) inhibitors, Other treatment combinations
- Where
- Canada
- Volunteers
- 1,249,636 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Diabetes Mellitus, Diabetic Retinopathy
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
The study's primary objective is to determine whether the PRSS improves the optimal timing of photocoagulation in diabetic patients in VA.
- Trial name
- NCT00119535
- Testing
- Implementation of Proactive Diabetes Eye Care Program
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy
Diabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4
The overall objective of this project is to describe the prevalence of and risk factors to diabetic neuropathy in a representative cohort of diabetes patients and to investigate pathophysiological conditions in those patients…
- Conditions
- Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy, Diabetic Foot, Foot Deformities
- Trial name
- DANES (NCT05043636)
- Testing
- Vagus, HeartsTrends, Sudoscan
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
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