Clinical trials: Diabetes Related Complications
Diabetic Retinopathy
Routine Clinical Practice for Use of Intravitreal Aflibercept Treatment in Patients With Diabetic Macular Edema
The main objectives of this observational study were to describe outcomes, monitoring and treatment patterns of patients with diabetic macular edema in routine clinical practice who are either treatment naïve patients or…
- Trial name
- APOLLON (NCT02924311)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- France
- Volunteers
- 402 people
- Sponsor
- Bayer
Diabetic Foot Ulcers
LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers
The LeucoPatch™ study goal is to investigate whether the fully autologous growth factor-containing dressing LeucoPatch™ has a positive effect on healing rates of diabetic foot ulcers.
- Trial name
- NCT01454401
- Testing
- LeucoPatch treatment
- Where
- 7 sites in Denmark, Sweden
- Volunteers
- 60 people
- Sponsor
- Reapplix
Diabetic Neuropathies
Randomized Study of Intravenous Immunoglobulin (IVIg) in Patients With Subacute Proximal Diabetic Neuropathy
OBJECTIVES: I. Determine the effect of intravenous immunoglobulin on recovery time of patients with proximal diabetic neuropathy. II. Determine whether rate of response is dose dependent in these patients.
- Trial name
- NCT00004407
- Testing
- immune globulin
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Macular Degeneration, Diabetic Retinopathy
Ocular Discomfort Assessment After Intravitreal Injections
In this study, ocular discomfort following intravitreal injection in naïve patients will be studied, as well as the efficacy of wetting agent (Optive eyewash) to prevent ocular discomfort.
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Artery Occlusion, Myopia, Degenerative
- Trial name
- EVAGO (NCT02806830)
- Testing
- Optive
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Pressure Ulcer, Leg Ulcer
Evaluation Of An Advanced Borderless Dressing
This study will gather preliminary clinical, health economic, and safety data on the treatment of chronic wounds with the ALLEVYN Life Non-Bordered dressing compared to standard of care treatment when used on a wound.
- Conditions
- Pressure Ulcer, Leg Ulcer, Diabetic Foot Ulcer
- Trial name
- NCT03146845
- Testing
- ALLEVYN Life Non-Bordered, Standard Care
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Foot Ulcer, Diabetic
A Comparison of an Investigational Dressing to Tegaderm Matrix Wound Dressing in the Management of Diabetic Foot Ulcers
The primary objective is to: Assess the effect of the Non-adherent study dressing to 3M Tegaderm Matrix Dressing with PHI technology on wound healing in patients with a diabetic foot ulcer.
- Trial name
- NCT01013792
- Testing
- Wound Dressing
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Solventum US LLC
Diabetic Foot Ulcers
Safety and Preliminary Efficacy Study of Nicotine Gel to Treat Diabetic Foot Ulcers
The purpose of this study is to evaluate the safety and preliminary efficacy of low dose nicotine gel in patients with chronic diabetic ulcers
- Trial name
- NCT00316537
- Testing
- ATG002 (study drug)
- Where
- 13 sites in United States
- Volunteers
- 48 people
- Sponsor
- CoMentis
Chronic Ulcer, Venous Ulcer
Efficacy of PICO Single-use System in Chronic Ulcers
A clinical trial will be carried out comparing the efficacy of PICO system based on negative pressure therapy (NPT) in adults with chronic ulcers compared to conventional treatments.
- Conditions
- Chronic Ulcer, Venous Ulcer, Diabetic Foot Ulcer, Pressure Injury
- Trial name
- NCT05877378
- Testing
- Single-use negative pressure therapy (PICO)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Diabetes Mellitus, Essential Hypertension
Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy
Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy.
- Conditions
- Diabetes Mellitus, Essential Hypertension, Renal Failure
- Trial name
- NCT00295555
- Testing
- Effects of doxazosin on morning surge in diabetic patients
- Where
- Japan
- Volunteers
- 98 people
- Sponsor
- Yokohama City University Medical Center
Diabetic Retinopathy, Periodontitis
Periodontitis Severity in Patients With Diabetic Retinopathy
The aim of this observational study is to investigate the relationship between periodontal disease severity and retinal layer thickness in patients diagnosed with diabetic retinopathy (DR), using optical coherence tomography…
- Trial name
- NCT07137013
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Type 2 Diabetes, Diabetic Nephropathy
Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
Angiotensin type-1 receptor (AT1R) blockers (ARBs) have been recognized recently as regulators of glucose and lipid metabolism in adipocytes and adipose tissue.Moreover telmisartan and irbesartan have been recognized recently as…
- Trial name
- NCT00361023
- Testing
- losartan
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetic Foot Ulcer, Wound
Investigation of the Effects of Different Exercise on Wound Healing in Patients wıth Diabetic Foot Wounds
Diabetic foot ulcers are a common complication of diabetes mellitus and are associated with delayed wound healing, impaired quality of life, and an increased risk of lower extremity amputation.
- Trial name
- NCT05422846
- Testing
- standard treatment, aerobic exercise, exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Harran University
Diabetic Retinopathy, Diabetic Macular Edema
Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema
Background: Diabetic macular edema (DME) is a common condition in people with diabetes. DME occurs when blood vessels in the eye leak fluid, resulting in swelling inside the back of the eye and progressive vision loss.
- Trial name
- NCT01168258
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Foot Ulcer
Outpatient Nurse Managed Counseling Program for Patients With Diabetic Foot Ulceration: a Pilot Study
The purpose of the study is to evaluate the feasibility and effectiveness of a physician directed nurse managed earlier outpatient counselling intervention for patients with diabetic foot ulceration.
- Trial name
- NCT01731808
- Testing
- Nursing counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 19 people
- Sponsor
- Zurich University of Applied Sciences
Diabetic Macular Edema, Diabetic Retinopathy
Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME
The objective of this study is to test the hypothesis that following the use of intravitreal dexamethasone implant for the treatment of DME, there will be an observable increase in the capillary density plexus as denoted by the…
- Conditions
- Diabetic Macular Edema, Diabetic Retinopathy, Retinal Ischemia
- Trial name
- ICOD (NCT04038125)
- Testing
- Ozurdex Drug Implant Product
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Retina Macula Specialists of Miami, LLC
Diabetic Retinopathy, Retinal Detachment
Pars Plana Vitrectomy (PPV) Versus Preoperative Intravitreal Bevacizumab Plus PPV to Treat Diabetic Tractional Retinal Detachment (IBETRA)
The purpose of this study is to compare the amount of intraoperative intraocular bleeding during 23-gauge pars plana vitrectomy (PPV) for diabetic traction retinal detachment (TRD) with and without preoperative intravitreal…
- Trial name
- IBETRA (NCT00690768)
- Testing
- Bevacizumab, pars plana vitrectomy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Diabetic Foot
a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis
Osteomyelitis is a frequent complication of diabetic foot ulcer. Several therapeutic strategies are used : medical treatment with antibiotics and foot offloading or surgical treatment consisting in the resection of infected bone…
- Trial name
- DIPIOS (NCT00578890)
- Testing
- Medical/surgical treatment versus medical treatment
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Retinopathy
Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema
This study will evaluate which of the three following treatment options is better for diabetic macular edema: laser alone, steroid injection alone, or steroid injection followed by laser.
- Trial name
- NCT00231023
- Testing
- Peribulbar Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Foot Ulcer
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Diabetic Foot Ulcers
This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Diabetic Foot Ulcers
- Trial name
- NCT07039396
- Testing
- NeoThelium FT (HCT/P 361)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- NuScience Medical Biologics, LLC
Diabetic Macular Edema
Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE)
This study is a Phase I/II, multicenter, randomized, study of the efficacy and safety of ranibizumab injection monotherapy verses a duel therapy of 0.3mg ranibizumab combined with ultra wide, 200° field angiography guided pan…
- Trial name
- DAVE (NCT01552408)
- Testing
- 0.3 mg ranibizumab, Targeted Pan Retinal Photocoagulation
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- David M. Brown, M.D.
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