Clinical trials: Diabetes Type 1
Diabetes Mellitus, Type 1
A Study of LY2605541 (Insulin Peglispro) and Human Insulin Concentrations in Fat Tissue
LY2605541 is an investigational drug being developed for the treatment of diabetes mellitus. This study is designed to understand how the body handles the investigational drug, and to measure the quantity of LY2605541 in fat…
- Trial name
- NCT02109029
- Testing
- Insulin Peglispro, Human Insulin
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Subcutaneous Administration of Teplizumab in Adults With Type 1 Diabetes
The purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of subcutaneously administered teplizumab in adults with relatively recent onset T1DM, greater than 12 weeks and…
- Trial name
- SUBCUE (NCT01189422)
- Volunteers
- 1 people
- Sponsor
- MacroGenics
Melanoma
Novel Adjuvants for Peptide-Based Melanoma Vaccines
This is a study to determine the efficacy of a melanoma vaccine chemotherapy cocktail composed of CTLA-4 antibody; tyrosinase, gp100, and MART-1 peptides; and incomplete Freund's adjuvant (IFA) with or without interleukin-12 in…
- Trial name
- NCT00028431
- Testing
- MDX-CTLA4 Antibody; Tyrosinase/gp100/MART-1 Peptides Melanoma Vaccine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Southern California
Diabetes
Evaluation of Extended Wear Infusion Set (EWIS) in Patients With Type 1 Diabetes
The purpose of this study is to collect confirmatory clinical data to support 6 or 7 days wear of EWIS (Extended Wear Infusion Set).
- Trial name
- NCT04113694
- Testing
- Extended Infusion Set
- Where
- 15 sites in United States
- Volunteers
- 291 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetic Foot Ulcer
Prospective, Multicenter, RCT of the Tenex Ultrasound System
The goal of this multicenter randomized controlled trial is compare standard of care (SOC) to Tenex MicroTip ultrasound therapy plus SOC in patients with Wagner 1-2 diabetic foot ulcers.
- Trial name
- NCT06137222
- Testing
- Tenex TXB MicroTip Ultrasound system plus SOC, Standard of Care for diabetic foot ulcer
- Where
- 2 sites in United States
- Volunteers
- 148 people
- Sponsor
- Tenex Health Inc.
Type 2 Diabetes
A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes
The study is to assess the safety, pharmacokinetics, and pharmacodynamic profile of HMS1005 in patient with diabetes
- Trial name
- NCT07568678
- Testing
- HMS1005
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hua Medicine Limited
Type 2 Diabetes Mellitus (T2DM)
Multiple Dose Study Of PF-05231023 In Obese Adult Subjects
This is a trial in obese subjects to study the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple doses of PF-05231023.
- Trial name
- NCT01923389
- Testing
- 100 mg PF-05231023
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Pfizer
Diabetes Mellitus Type 1
A Double-blinded, Randomised, Two -Period Crossover Euglycemic Clamp Trial Investigating the Pharmacokinetics, Glucodynamics and Safety of BioChaperone Insulin Lispro and Insulin Lispro (Humalog®) in Subjects With Type 1 Diabetes
The addition of Biochaperone to insulin lispro may accelerate the onset and shorten the duration of action of insulin lispro due to a facilitation of the absorption of the insulin after subcutaneous injection.
- Trial name
- NCT02029924
- Testing
- BioChaperone insulin lispro, Humalog®
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Adocia
Type 1 Diabetes Mellitus
Group Education Curriculum for Older Teens With Type 1 Diabetes
SMART T1D is a research study that offers interactive diabetes education for teens with type 1 diabetes in peer groups led by diabetes nurse educators.
- Trial name
- SMART T1D (NCT03147274)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes Mellitus
Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus
In this prospective, dual-center, open trial, patients with recent onset type 1 diabetes will receive one dose of allogenic Adipose tissue-derived stromal/stem cells (1x106 cells/kg) and oral cholecalciferol 2000UI/day for 24…
- Trial name
- NCT03920397
- Testing
- Infusion of adipose tissue-derived stem/stromal cells and oral Cholecalciferol supplementation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Type 1 Diabetes, Diabetes Distress
UK MyREMEDY Clinical Trial
The UK MyREMEDY study investigates whether MyDiaMate, an online self-help program, can effectively improve the mental health of adults with type 1 diabetes compared to those receiving care as usual.
- Trial name
- UK-MyREMEDY (NCT06448338)
- Testing
- MyDiaMate
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- King's College London
Diabetes Mellitus, Type 1
¿Can mySugr App Improve Knowledge and Self-management of People With Type 1 Diabetes Mellitus?
This project is based on the contribution that an app can offer for improving knowledge and self-management of people with type 1 diabetes.
- Trial name
- NCT03819335
- Testing
- mySugr app, Standard care
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Diabetes Mellitus, Type 1, Overweight
Liraglutide in Type 1 Diabetes
A randomised, double-blind, placebo controlled study of the effect of liraglutide as an additional treatment to insulin on HbA1c, body weight and hypoglycaemia in poorly regulated type 1 diabetes patients.
- Trial name
- NCT01612468
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Steno Diabetes Center Copenhagen
Stage 3 Type 1 Diabetes
Autologous CD6-CAR Treg Cells for Patients With Stage 3 Type 1 Diabetes
Type 1 diabetes (T1D) is a persistent and gradually increasing genetic autoimmune disease requiring life-long management. The disease commonly impacts children. However, a quarter of cases are diagnosed in adults.
- Trial name
- NCT07395050
- Testing
- AutoCD6-CAR Treg cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Effect of a Structured Educational Intervention Through Mobile App on Hemoglobin A1c (HbA1c), Self-Efficacy and Self- Care in Adolescent With Type 1 Diabetes (T1DM)
This study aims to evaluate the effectiveness of a mobile health (mHealth) educational intervention for adolescents with Type 1 Diabetes Mellitus (T1DM).
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Type 1 Diabetes Mellitus, HbA1c
- Trial name
- (T1DM) (NCT07689318)
- Testing
- educational intervention via mobile app
- Volunteers
- 84 people
- Sponsor
- Shifa Tameer-e-Millat University
Type 1 Diabetes Mellitus
Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients
Primary Objective: To demonstrate the non-inferiority of insulin glargine 300 units per milliliter (U/ml) in comparison to insulin degludec 100 U/ml on glycemic control and variability in participants with diabetes mellitus.
- Trial name
- inRange (NCT04075513)
- Testing
- Insulin glargine, 300 U/ml, Insulin degludec, 100U/ml, Background therapy: Rapid acting insulin analogs
- Where
- 7 sites in United States, Brazil and 5 more
- Volunteers
- 343 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1
Clinical Startup of the 670G Closed Loop Insulin Delivery System
The purpose of this project is to track initiation and the first year of clinical use of the newly FDA approved 670G closed loop insulin delivery system by patients who have requested this system.
- Trial name
- 670Gstartup (NCT03017482)
- Testing
- Medtronic 670G
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Stanford University
Type 1 Diabetes Mellitus
Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes
The Pizza-Salami-Study aims to investigate the efficacy of carbohydrate plus fat/protein (CFP) counting compared with carbohydrate (CARB) counting using normal and dual-wave bolus in sensor-augmented pump therapy in children and…
- Trial name
- NCT01400659
- Testing
- CFP counting, CARB counting
- Volunteers
- 42 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes, Hypoglycemia
Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)
This study will recruit drivers with Type 1 diabetes from across the U.S. and assign them to four groups based on their presumed risk level- routine care low risk, routine care high risk, or to one of two Internet interventions…
- Trial name
- NCT01563887
- Testing
- DD.com, DD.com + MI
- Where
- United States
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes, Diabetes Mellitus, Type 1
The HEADWIND-Study
To analyse driving behavior of individuals with type 1 diabetes in eu- and progressive hypoglycaemia using a validated research driving simulator.
- Trial name
- HEADWIND (NCT04035993)
- Testing
- Controlled hypoglycaemic state while driving with a driving simulator
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern