Clinical trials: Diabetes Type 2
Type 2 Diabetes
DIabetic Retinopathy Candesartan Trials
The primary objective is to determine whether candesartan, compared to placebo reduces the progression of diabetic retinopathy in normoalbuminuric type 2 diabetic patients with retinopathy.
- Trial name
- DIRECT (NCT00252694)
- Testing
- candesartan
- Volunteers
- 4,717 people
- Sponsor
- AstraZeneca
PreDiabetes
Personalizing Sleep Interventions to Prevent Type 2 Diabetes in Community Dwelling Adults With Pre-Diabetes
This study will use continuous glucose monitoring and actigraphy to examine whether a personalized, daily sleep extension intervention improves glucose regulation for community dwelling, sleep-restricted adults with pre-diabetes.
- Trial name
- NCT03398902
- Testing
- Sleep extension, Habitual sleep
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- New York University
Type 2 Diabetes
Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Saxagliptin as Monotherapy in Pediatric Patients With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy, safety, tolerability, of Saxagliptin in pediatric patients with type 2 diabetes.
- Trial name
- NCT01204775
- Testing
- Saxagliptin, Metformin IR, Metformin (Active Rescue)
- Where
- 16 sites in United States, Russia and 2 more
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Type2 Diabetes
A Psychological-behavioral Intervention for Physical Activity in Type 2 Diabetes
The focus of this study is to examine the feasibility, acceptability, and impact of a customized, combined positive psychology and motivational interviewing (PP-MI) health behavior intervention versus a motivational interviewing…
- Trial name
- BEHOLD-8 (NCT03150199)
- Testing
- Positive Psychology + Motivational Interviewing, MI-based Health Education Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
This Study Combines Data From 3 Other Studies Testing Empagliflozin in Patients With Diabetes or With Chronic Heart Failure. The Study Looks at the Numbers of Patients Who Had Lower Limb Amputations
The primary objective of this exploratory meta-analysis is to evaluate the frequencies, incidence rates, and hazard ratios of lower-limb amputation (LLA) events (primary outcome) and of adverse events related to amputation…
- Trial name
- NCT04937816
- Testing
- Empagliflozin
- Where
- Germany
- Volunteers
- 16,746 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
Promoting the Universal Medication Schedule Via Mobile and EHR Technologies
The purpose of this study test the effectiveness of the Universal Medication Schedule (UMS), which was designed as a strategy to standardize and simplify medication instructions to support safe and effective prescription drug use…
- Trial name
- NCT02248857
- Testing
- UMS Strategy, SMS Texting Reminders
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Northwestern University
Type 2 Diabetes Mellitus
A Study to Test the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK1006 (MK-1006-002)(COMPLETED)
This study will assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of MK1006
- Trial name
- NCT00757601
- Testing
- MK1006
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Alogliptin/Pioglitazone (Liovel) Combination Tablets Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus
The purpose of this survey is to examine the safety and efficacy of long-term use of alogliptin/pioglitazone(Liovel) combination tablets in patients with type 2 diabetes mellitus determined as warranting combination therapy with…
- Trial name
- NCT01990300
- Testing
- Alogliptin/Pioglitazone
- Where
- Japan
- Volunteers
- 3,281 people
- Sponsor
- Takeda
Diabetes, Diabetes Mellitus, Type 2
A Trial Comparing Sequential Addition of Insulin Aspart Versus Further Dose Increase With Insulin Degludec/Liraglutide in Subjects With Type 2 Diabetes Mellitus, Previously Treated With Insulin Degludec/Liraglutide and Metformin and in Need of Further Intensification
This trial is conducted globally. The aim of the trial is to compare sequential addition of insulin aspart versus further dose increase with insulin degludec/liraglutide in subjects with type 2 diabetes mellitus, previously…
- Trial name
- DUAL™ (NCT02100475)
- Testing
- insulin degludec/liraglutide, insulin aspart
- Where
- 60 sites in United States, Argentina and 8 more
- Volunteers
- 31 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, Hypertension
Expanding Technology-Enabled Nurse Delivered Chronic Disease Care
The purpose of this study is to investigate whether the self-management of diabetes and hypertension can be improved with the use of mobile monitoring devices and nursing support.
- Trial name
- EXTEND (NCT05120544)
- Testing
- EXTEND Plus, EXTEND
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 2
This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus
This study is to determine if inhaled insulin is effective in treating type 2 diabetes mellitus.
- Trial name
- NCT00418522
- Testing
- Insulin glargine, Inhaled Insulin (Exubera)
- Where
- 73 sites in United States, Puerto Rico
- Volunteers
- 413 people
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus
Insulin Glargine at Bedtime or in AM Versus NPH
To compare the efficacy and safety of once-nightly insulin glargine versus a single morning injection of glargine or once-nightly NPH insulin in ethnic minority type 2 diabetic patients inadequately controlled on combination oral…
- Trial name
- NCT00686712
- Testing
- 1- Insulin glargine QHS, 2 - Insulin glargine QAM, 3 - NPH insulin QHS
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Charles Drew University of Medicine and Science
Type 1 Diabetes, Type 2 Diabetes
Nurse Telephone Management of Cholesterol in Diabetes
The current project is evaluating the effect of a nurse-administered phone care in diabetes to improve access to care and healthcare delivery.
- Trial name
- NATCHOS (NCT00950963)
- Testing
- Phone Counseling, Standard Clinical Care
- Where
- United States
- Volunteers
- 762 people
- Sponsor
- Denver Health and Hospital Authority
Type 2 Diabetes
Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes
The purpose of this study is to evaluate the effect of Dipeptidyl peptidase (DPP) -IV inhibitor Vildagliptin vs. Glibenclamide on circulating endothelial progenitor cells (EPCs) number in type 2 diabetes patients in metformin…
- Trial name
- NCT01822548
- Testing
- Vildagliptin, Glibenclamide, Metformin
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Diabetes Mellitus, Type 2
Sulfonylurea Add-on Study in Patients With Type 2 Diabetes Mellitus (0431-035)
The purpose of this clinical study is to determine the safety and efficacy of an investigational drug in patients with Type 2 diabetes mellitus.
- Trial name
- NCT00106704
- Testing
- Comparator: Sitagliptin, Comparator: Pioglitazone
- Volunteers
- 441 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2
A Study of LY2608204 in Patients With Type 2 Diabetes
Safety study with multiple oral doses of LY2608204 given to patients with type 2 diabetes. Study subjects will receive once daily doses of LY2608204 for a total treatment duration of up to 28 days.
- Trial name
- NCT01247363
- Testing
- LY2608204
- Where
- 2 sites in United States, Singapore
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
Hypercholesterolemia, Mixed Dyslipidemia
Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia
The purpose of this study is to evaluate the effect of 12 weeks of subcutaneous evolocumab taken monthly compared with subcutaneous placebo taken monthly on low density lipoprotein cholesterol (LDL-C) in adults with type 2…
- Conditions
- Hypercholesterolemia, Mixed Dyslipidemia, Type 2 Diabetes
- Trial name
- BANTING (NCT02739984)
- Testing
- Evolocumab
- Where
- 66 sites in United States, Belgium and 5 more
- Volunteers
- 424 people
- Sponsor
- Amgen
Type 2 Diabetes Mellitus
An Evaluation of a Novel Glucose Sensing Technology in Type 2 Diabetes
To evaluate the impact of the Abbott Sensor Based Glucose Monitoring System on glycaemic control (HbA1c) compared to Self Monitoring Blood Glucose (SMBG) testing using a randomised controlled study design in adults with Type 2…
- Trial name
- REPLACE (NCT02082184)
- Testing
- Sensor Based Glucose Monitoring System, Standard Blood Glucose Monitoring
- Where
- 26 sites in France, Germany and 1 more
- Volunteers
- 302 people
- Sponsor
- Abbott Diabetes Care
Type2 Diabetes
Chronic Passive Heating in Individuals With T2DM
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterized by chronic hyperglycemia and progressive insulin resistance, which progressively lead to macro- and microvascular damage and subsequent impairments in blood…
- Trial name
- NCT04858321
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Portsmouth
Diabetes Mellitus, Type 2, Coronary Artery Disease
Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
The purpose of this study is to determine whether bromodomain extraterminal domain (BET) inhibition treatment with RVX000222 in high-risk type 2 diabetes mellitus patients with coronary artery disease increases the time to major…
- Trial name
- BETonMACE (NCT02586155)
- Testing
- Apabetalone, Atorvastatin, Rosuvastatin
- Where
- 214 sites in Argentina, Australia and 13 more
- Volunteers
- 2,425 people
- Sponsor
- Resverlogix Corp
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