Clinical trials: Diabetes Type 2
Diabetes Mellitus, Type II
Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy
2 weeks screening period, 4 weeks run-in period, 24 weeks double-blind treatment period, to evaluate the Safety and Efficacy of Retagliptin Plus Henagliflozein added to Metformin compared to Retagliptin or Henagliflozein in…
- Trial name
- NCT04667143
- Testing
- Retagliptin, Henagliflozein, metformin XR
- Volunteers
- 760 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Obesity
Weight Loss and Reversing T2D Through eHealth Coaching
Background: Systematic reviews conclude that Internet and mobile interventions can significantly change lifestyle in a short time span.
- Trial name
- LIVA (NCT03788915)
- Testing
- Online dietetic lifestyle counseling, Usual care
- Where
- 2 sites in Denmark
- Volunteers
- 340 people
- Sponsor
- University of Southern Denmark
Type 2 Diabetes Mellitus
A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test
The study has a randomized, double-blind, placebo-controlled, double dummy and eight-way cross-over design. Males with T2DM on a stable metformin monotherapy will be screened for participation in the study.
- Trial name
- DXM2 (NCT01936025)
- Testing
- Dextromethorphan, Sitagliptin
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Weight Loss, Diabetes Mellitus, Type 2
Reducing Weight and Diabetes Risk in an Underserved Population (STRIDE)
The purpose of this study is to examine the effectiveness of a lifestyle intervention designed to reduce weight and diabetes risk in a population of individuals with mental illness who are also taking antipsychotic medications.
- Conditions
- Weight Loss, Diabetes Mellitus, Type 2, Psychotic Disorders
- Trial name
- STRIDE (NCT00790517)
- Testing
- Premier Lifestyle Intervention with DASH Diet
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaiser Permanente
Type 2 Diabetes Mellitus
Avandia™ + Amaryl™ or Avandamet™ Compared With Metformin (AVALANCHE™ Study)
The incidence of type 2 diabetes is on the increase. According to recent Canadian Diabetes Association guidelines glucose control, based on the A1C measurement, needs to be achieved within a 6-12 month period of time after the…
- Trial name
- AVALANCHE (NCT00131664)
- Testing
- Avandamet, Avandia and Amaryl, Metformin
- Where
- Canada
- Volunteers
- 391 people
- Sponsor
- Canadian Heart Research Centre
Type 2 Diabetes Mellitus
The Impact of Ursodeoxycholic Acid and Probiotics on Metabolic Outcomes in Type 2 Diabetic Patients Taking Metformin
A monocentric prospective randomized double-blind controlled study included 90 patients with T2DM on metformin therapy. Patients were randomized into three groups: a metformin group (1000 to 2000 mg daily in two doses), a…
- Trial name
- NCT07072949
- Testing
- Metformin Monotherapy, Metformin combined with probiotic (Normia® Jadran Galenski Laboratory) supplementation, Triple therapy - metformin, probiotic and ursodeoxycholic acid (Bilexin®, Bosnalijek)
- Where
- Bosnia and Herzegovina
- Volunteers
- 90 people
- Sponsor
- University of Banja Luka
Type 2 Diabetes Mellitus
A Study Using Swedish Registries to Find Out How Many People With Type 2 Diabetes Had Cardiovascular Disease and Started Treatment With Empagliflozin Between 2015 and 2017
This study aims to describe the prevalence of type 2 diabetes mellitus (T2DM) patients with established cardiovascular disease (CVD) according to the (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus…
- Trial name
- NCT04927858
- Testing
- Empagliflozin
- Where
- Sweden
- Volunteers
- 460,558 people
- Sponsor
- Boehringer Ingelheim
Obesity, Insulin Resistance
Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with…
- Trial name
- NCT01926938
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 2
Inspiratory Muscle Training on Glycemic Control in Individuals With Type 2 Diabetes
In diabetic individuals, changes in ventilatory muscle strength and lung function have been demonstrated over the years. The onset and progression of chronic complications in diabetes should be avoided by reaching glycated…
- Trial name
- NCT03191435
- Testing
- Inspiratory muscle training.
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Insulin Resistance, Menstrual Cycle
Effects of Antipsychotics on Brain Insulin Action in Females
Females treated with antipsychotics have higher rates of comorbid metabolic syndrome than males. Despite this, females have historically been excluded from many mechanistic studies due to confounding effects of menstrual cycles.
- Conditions
- Insulin Resistance, Menstrual Cycle, Type 2 Diabetes, Antipsychotics
- Trial name
- NCT06251635
- Testing
- Olanzapine 2.5Mg Oral Tablet, Insulin Lispro 100 UNT/ML, Saline
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Type 2 Diabetes
Effect of Arginine on Microcirculation in Patients With Diabetes
Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood viz: nitric oxide.
- Trial name
- NCT00902616
- Testing
- L-arginine
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Tameside Hospital NHS Foundation Trust
Diabetes Mellitus, Type 2
Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships
The goal of this study is to develop, implement, and evaluate a patient-centered triage and referral model designed to improve health outcomes for individuals with uncontrolled type 2 diabetes mellitus (T2DM) and unmet…
- Trial name
- THRIVE-DM (NCT07043426)
- Testing
- THRIVE-DM, Standard of care
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Boston Medical Center
Diabetes Mellitus, Type 2
Managing Diabetes to Gain Opportunities for a More Active Life
The purpose of this novel patient-facing disease management intervention is to develop and test a system embedded within the electronic medical record to engage patients in personalized goal setting and chronic disease management.
- Trial name
- NCT03692208
- Testing
- My Diabetes Goal Survey and Optional Care Management
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Chicago
Diabetes, Type 2 Diabetes (T2D)
NYULMC CareSmarts Pilot
CareSmarts is a theory-driven behavioral intervention designed to improve self-care among patients with Type 2 diabetes (T2D) with poor glycemic control (HbA1c>8%), through multiple mediators, including cuing, education…
- Trial name
- NCT02726217
- Testing
- CareSmarts Mobile Health Diabetes Program, Standard of Care Reminders and Self Assessments
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus Type 1 and 2, Diabetes Mellitus Complications
Study to Assess Pharmacodynamics of RM-131 in Patients With Diabetic Gastroparesis
The purpose of this study is to evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) profile and the safety and tolerability of RM-131 in patients with diabetes mellitus and delayed gastric emptying.
- Conditions
- Diabetes Mellitus Type 1 and 2, Diabetes Mellitus Complications, Gastroparesis, Gastrointestinal Motility Disorder
- Trial name
- NCT01394055
- Testing
- RM-131
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Motus Therapeutics, Inc.
Type 2 Diabetes (T2DM)
Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists
Minorities have higher rates of diabetes, poorer glucose control, and higher complications and mortality rates than white people.
- Trial name
- Beta (NCT07325435)
- Testing
- SGLT-2 inhibitor, GLP1-RA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MaryAnn Banerji
Type 2 Diabetes Mellitus (T2DM)
Impact of LLL and Aerobic Exercise on Peripheral Arterial Outcomes in Patients With Type 2 Diabetes
Diabetes is one of the fastest-growing diseases worldwide, It has Devastating macrovascular complications (cardiovascular disease) and microvascular complications (such as diabetic kidney disease, diabetic retinopathy, and…
- Trial name
- LLLT (NCT06827171)
- Testing
- aerobic exercise + low-level laser therapy, Aerobic exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nouran Hesham Slama Younis
Type 2 Diabetes Mellitus
A Study of LY2189265 in Japanese Participants With Type 2 Diabetes Mellitus
The purpose of this trial is to examine the efficacy and safety of once-weekly LY2189265 in participants with type 2 diabetes mellitus who are not taking oral antidiabetic medication.
- Trial name
- NCT01558271
- Testing
- LY2189265, Liraglutide
- Where
- 14 sites in Japan
- Volunteers
- 492 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
Safety and Tolerability Study of MEDI0382 in Japanese Preobese or Obese Subjects With Type 2 Diabetes
This is a Phase 2a study designed to assess the safety and tolerability of MEDI0382 titrated up to a dose level of 100, 200 or 300 µg from 50 µg vs Placebo across 48 days in Japanese subjects.
- Trial name
- NCT03645421
- Testing
- MEDI0382 100 μg, MEDI0382 200 μg, MEDI0382 300 μg
- Where
- 5 sites in Japan
- Volunteers
- 61 people
- Sponsor
- AstraZeneca
Insulin Resistance, Type 2 Diabetes
Insulin Resistance in the Control of Intestinal Lipid Metabolism
America's preferential consumption of high-fat/high-sugar foods is a driving force in the current epidemic of obesity and insulin resistance.
- Trial name
- NCT02020343
- Testing
- taste tests
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia