Clinical trials: Diabetes Type I
Type 1 Diabetes Mellitus
Euglycemic Clamp Dose-response Study Comparing a New Insulin Glargine Formulation With Lantus®
Primary Objective: To assess the total metabolic effect ratios of a new insulin glargine formulation versus Lantus® Secondary Objectives: To assess the exposure ratios of a new insulin glargine formulation versus Lantus® To…
- Trial name
- NCT01195454
- Testing
- Insulin glargine (HOE901)
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Sanofi
Quality of Life, Burden, Dependency
Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life
The use by diabetes patients of real-time Continuous Glucose Monitoring (CGM) system is becoming widespread and has changed diabetic practice. Automated closed-loop (CL) insulin therapy has come of age.
- Trial name
- IMPLIQUE (NCT04939766)
- Testing
- Activation of a closed loop device in an insulin pump device with GCM
- Volunteers
- 250 people
- Sponsor
- VitalAire
Islet Transplantation in Diabetes Mellitus Type 1
Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation
The objective of this clinical trial was: to assess whether Reparixin leads to improved transplant outcome as measured by glycaemic control following intra-hepatic infusion of pancreatic islets in patients with Type 1 diabetes…
- Trial name
- REP0211 (NCT01817959)
- Testing
- Reparixin
- Where
- 9 sites in United States, Czechia and 3 more
- Volunteers
- 51 people
- Sponsor
- Dompé Farmaceutici S.p.A
Diabetes Mellitus, Type 1
Type 1 Diabetes and the Brain in Children
The investigators have previously studied a group of young children with T1D using brain MRI, age-appropriate neurocognitive testing and continuous glucose monitoring, followed for 18 months.
- Trial name
- NCT02351466
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus, Hypoglycemia
How to be Safe With Alcoholic Drinks in Diabetes
The purpose of this study is to show that during and after drinking beer a treatment strategy by insulin bolus and reduction of basal rate reduces the rate of hyperglycaemia without an increase of hypoglycaemic events compared to…
- Trial name
- BEER (NCT02518022)
- Testing
- Insulin
- Where
- Germany
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus
Physiologic Response to Glucagon at Varying Insulin Levels
The purpose of this research study is to test how different levels of insulin block the effect of glucagon. Insulin is a hormone that lowers blood glucose. Glucagon raises blood glucose.
- Trial name
- NCT01483651
- Testing
- Glucagon, Insulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Legacy Health System
Type 1 Diabetes, Type 2 Diabetes
Arginase Inhibition in Type 1 and Type 2 Diabetes Mellitus
To evaluate the efficacy of arginase inhibition on endothelial function in patients with type 1 diabetes and type 2 diabetes.
- Trial name
- NCT05806502
- Testing
- Nω-hydroxy-nor-arginine
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 1, Diabetic Ketoacidosis
Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes
The management goals of diabetic ketoacidosis (DKA) in the pediatric type 1 diabetes (T1DM) population are fluid and electrolyte repletion, insulin administration, and correction of acidosis in order to stabilize the patient.
- Trial name
- NCT02548494
- Testing
- Glargine, IV insulin, Electrolyte Correction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Chattanooga-Hamilton County Hospital Authority
Type 1 Diabetes, Type 2 Diabetes
Breaking Down Barriers to Diabetes Self-Care
Performance of self-care recommendations is key to the successful treatment of diabetes. However, many patients have difficulty adhering to diabetes self-care recommendations.
- Trial name
- NCT00142922
- Testing
- Breaking Down Barriers
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus
Open-Label Study of Dimethyl Fumarate in Adults With Type 1 Diabetes
This is a non-randomized, parallel-controlled, single-center, open-label clinical trial designed to evaluate the efficacy of dimethyl fumarate in preserving pancreatic beta-cell function in adults with type 1 diabetes, as well as…
- Trial name
- NCT07548996
- Testing
- Dimethyl Fumarate Enteric-coated Capsules, Insulin
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Nanjing Medical University
Type 1 Diabetes
Effectiveness of Aerobic Exercise to Mitigate Hyperglycemia After Fasted Resistance Exercise
Certain types and timings of exercise are known to cause hyperglycemia (high blood glucose) in people with type 1 diabetes. Hyperglycemia increases the risk of most long-term complications for individuals with this complication.
- Trial name
- NCT05203653
- Testing
- Resistance exercise only, Resistance exercise plus cool down
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
AI-Predicted Disease Trajectories in Diabetes: A Retrospective Study
The study explores the utilization of artificial intelligence (AI) to predict disease progression trajectories in patients with diabetes.
- Trial name
- AI-TRYDIA (NCT06280729)
- Testing
- AI-Analyis
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type I, Stigma
Effects of Education on Stigma and Quality of Life in Individuals With Type 1 Diabetes
This clinical trial aimed to examine the effects of anti-stigma psychoeducation based on the Roy Adaptation Model on stigma and quality of life in individuals with Type 1 Diabetes.The main questions it aims to answer are: 1.
- Conditions
- Diabetes Mellitus, Type I, Stigma, Quality of Life (QOL)
- Trial name
- NCT06850441
- Testing
- Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Izmir Katip Celebi University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
A Canadian Study of the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellitus
The purpose of this study is to collect historical data in real life conditions in a large group of people who have type 1 or type 2 diabetes and were treated with Tresiba® (insulin degludec) for at least 6 months.
- Trial name
- CAN-TREAT (NCT03674866)
- Testing
- Insulin degludec
- Where
- 32 sites in Canada
- Volunteers
- 662 people
- Sponsor
- Novo Nordisk A/S
Hepatocellular Carcinoma (HCC), Immunotherapy
A Single-Arm, Multicenter, Exploratory Clinical Study of Transarterial Chemoembolization (TACE) Combined With Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection for the Treatment of Unresectable, Non-Metastatic Hepatocellular Carcinoma (HCC)
This is a single-arm, multicenter, exploratory clinical study designed to evaluate the efficacy and safety of TACE combined with Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection in patients with unresectable…
- Conditions
- Hepatocellular Carcinoma (HCC), Immunotherapy, PD-1, CTLA-4
- Trial name
- NCT07128251
- Testing
- TACE treatment, Iparomlimab and Tuvonralimab Injection (QL1706), Bevacizumab
- Volunteers
- 47 people
- Sponsor
- Anhui Provincial Hospital
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Type 1 Diabetes (T1D), Surgery, Day
Efficacy and Safety of the Minimed 780G® Advanced Hybrid Closed Loop System (AHCL) in Patients With Type 1 Diabetes Undergoing Surgery
An analytical observational study based on a cohort of patients who received training at San Ignacio University Hospital. Glycemic control metrics were compared between the perioperative and postoperative periods and the…
- Trial name
- AHCL & surgery (NCT06947031)
- Testing
- AHCL
- Where
- Colombia
- Volunteers
- 15 people
- Sponsor
- Hospital Universitario San Ignacio
Type 1 Diabetes
The Management of Glucose Control and Hypoglycemic Prevention Using Continuous Glucose Monitoring System in Patients With Type 1 Diabetes
This study was designed to evaluate the glucose control and hypoglycemic prevention effect of using continuous glucose monitoring system(CGMS) in patients with type 1 diabetes.
- Trial name
- NCT04684030
- Testing
- Continuous glucose monitoring system(CGMS), Self-monitoring of blood glucose (conventional fingerpricking method)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Type1diabetes
HIT on Hypoglycemic Risk in Type 1 Diabetes (T1D)
There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly.
- Trial name
- NCT03598400
- Testing
- high intensity interval training, moderate intensity continous training
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Diabetes Mellitus, Diabetes Mellitus, Adult-Onset
Classification of Adult-onset Diabetes in Five Subgroups in Pakistani Population
This study aims to classify adult-onset diabetes patients into distinct data-driven clusters, such as severe insulin-deficient, severe insulin-resistant, mild obesity-related, and mild age-related diabetes, based on clinical and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Adult-Onset, Diabetes Mellitus Type 1 and 2
- Trial name
- NCT06706609
- Volunteers
- 394 people
- Sponsor
- Getz Pharma
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.