Clinical trials: Diabetes Type I
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise Physiology Study
People with type 1 diabetes often find exercise very difficult to manage, because of the high risk for low blood glucose levels.
- Trial name
- NCT03090451
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus, Hypoglycemia
Hypoglycaemia Awareness Restoration Programme
Insulin treatment for type 1 diabetes inevitably carries risk of hypoglycaemia (low blood sugar) which can be severe enough to cause coma, seizure, even death.
- Trial name
- HARPdoc (NCT02940873)
- Testing
- HARPdoc courses, BGAT courses
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 99 people
- Sponsor
- King's College London
Diabetes Mellitus, Diabetes Mellitus, Type 1
A Novel mHealth Application Guided by an Optimization Algorithm for T1D Sensor-Augmented Insulin Injection Users
The Artificial Pancreas lab at McGill University has developed an optimization algorithm for adults with Type 1 Diabetes (T1D) on Multiple Daily Injection (MDI) therapy with the adjunctive use of glucose sensor technology…
- Trial name
- NCT04123054
- Testing
- Mobile App, Mobile App + Basal-Bolus Optimization Algorithm
- Where
- 2 sites in Canada
- Volunteers
- 84 people
- Sponsor
- McGill University
Type 1 Diabetes
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and…
- Trial name
- SOTA (NCT05696366)
- Testing
- Sotagliflozin, Volagidemab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Diego
Type1 Diabetes Mellitus, Adiposity
Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes
The purpose of this study is to assess the effects of adiposity on resistance to insulin's ability to suppress hepatic glucose production and to stimulate peripheral glucose metabolism in adolescents with type 1 diabetes.
- Trial name
- T1D (NCT03582956)
- Testing
- Euglycemic hyperinsulinemic clamp with tracer enhancement
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
New-onset Type 1 Diabetes Mellitus
Inducing Remission in Type 1 Diabetes With Alefacept
The purpose of this trial is to test whether a drug called alefacept will slow or halt destruction of the beta cells in the pancreas.
- Trial name
- T1DAL (NCT00965458)
- Testing
- Alefacept
- Where
- 15 sites in United States
- Volunteers
- 49 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Effect of Paired Testing to Poorly Controlled Chinese Diabetes on Glycemic Control and Self Care
This study aims is to evaluate the effect of introducing paired testing on actual testing frequency, glycemic control, psychosocial and behavioural aspects of poorly controlled diabetes patients in China.
- Trial name
- NCT02225691
- Testing
- Paired testing of blood glucose Accu-Chek®
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 6th People's Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
PROMISE Study: An Evaluation of an Implantable Continuous Glucose Sensor up to 180 Days
The purpose of this clinical investigation is to evaluate the accuracy of the Eversense® continuous Glucose Monitoring System (Eversense® 180 CGM System) measurements when compared with reference standard measurements up to 180…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PROMISE (NCT03808376)
- Testing
- Continuous Glucose Monitoring System
- Where
- 8 sites in United States
- Volunteers
- 208 people
- Sponsor
- Senseonics, Inc.
Type 1 Diabetes Mellitus
Combined Basal-bolus Insulin and Post-exercise Carbohydrate Feeding Strategy in T1DM
The investigators hypothesise that reducing basal insulin dose (Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk), whilst employing current carbohydrate feeding and rapid-acting insulin dose recommendations…
- Trial name
- NCT02204839
- Testing
- Basal insulin dose
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Northumbria University
Type 1 Diabetes
Ketoacidosis in Individuals With Type I Diabetes Mellitus (T1DM)
The purpose of this study is to investigate individuals with type 1 diabetes who were disconnected from their insulin pump and insulin therapy was started again after positive ketones (U) in the urine or blood β-hydroxybutyrate.
- Trial name
- NCT00970567
- Testing
- Different insulin therapy at different time points
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Charite University, Berlin, Germany
Hypoglycemia
Hypoglycemia Biomarkers to Predict Timing of a Hypoglycemic Event
The study aims to obtain a panel of biomarkers from hypoglycemic diabetic patients with either type 1 or type 2 diabetics and from control patients with type 1 or type 2 diabetes who didn't have hypoglycemia in the last 72 hours.
- Trial name
- NCT06652867
- Where
- Bahrain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Type1diabetes
Exercise Training and Endothelial Function in Type 1 Diabetes
Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological…
- Trial name
- EVaDia (NCT03528226)
- Testing
- Exercise Training Procedure, Normal life procedure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Lille
Diabetes, Diabetes Mellitus, Type 1
The Impact of Initiating/Switching to Insulin Detemir on Emotional Well-being and Treatment Satisfaction
This study is conducted in Europe. The aim of this study is to assess the well-being of patients following treatment with insulin detemir (Levemir®) in subjects with type 1 or type 2 diabetes in whom either initiation of or a…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- CONFIDENCE (NCT01542476)
- Testing
- insulin detemir
- Where
- Netherlands
- Volunteers
- 299 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Investigating the Safety and Effectiveness of Insulin Degludec in a Real World Population With Type 1 and 2 Diabetes Mellitus
This study is conducted in Europe. The aim of this non-interventional study is to investigate the safety and effectiveness of insulin degludec (Tresiba®) in a real world population with type 1 (T1DM) and 2 (T2DM) diabetes…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- ReFLeCT (NCT02392117)
- Testing
- insulin degludec
- Where
- 8 sites in Denmark, Germany and 6 more
- Volunteers
- 1,262 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Safety and Effectiveness of Automated Insulin Delivery (AID) Systems in Physically Active Adults With Type 1 Diabetes
Despite recent medical and technological advances, optimal glycemic control (time in range; TIR) and prevention of hypoglycemia remain significant challenges for people living with type 1 diabetes (T1DM).
- Trial name
- AIDE-1 (NCT05626725)
- Testing
- Automated insulin delivery system
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes
Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)
The goal of this application is to evaluate the safety and efficacy of atorvastatin as a potential treatment to preserve beta cell function in children and young adults with newly diagnosed type 1 diabetes (T1DM).
- Trial name
- TIDM (NCT00529191)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Diabetes Mellitus, Type 1 Diabetes
Supporting Medtronic 780G Insulin Pump Adoption in Latino Patients: A Spanish - Language Training Initiative
This study plans to learn more about whether a support program delivered in Spanish or both English and Spanish for bilingual families helps Latino youth with Type 1 Diabetes (T1D) successfully use the Medtronic MiniMed 780G…
- Trial name
- APOYO780G (NCT07720388)
- Testing
- Culturally and linguistically tailored onboarding and support program, Medtronic MiniMed 780G Insulin Pump System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Hypoglycemia
Single Ascending Doses of ZP4207 Administered in HV and in T1D to Evaluate Safety, Tolerability PKs and PDs of ZP4207 Compared to a Comparator
The trial is a randomized, double-blind First in Human trial to evaluate the safety and tolerability of ZP4207 in healthy volunteers (HV) and in insulin-induced hypoglycemic T1D (type 1 diabetes) subjects as compared to native…
- Trial name
- NCT02367053
- Testing
- ZP4207, Glucagon
- Where
- Germany
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
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