Clinical trials: Diabetes Type I
Type 1 Diabetes
Advanced Bolus Calculator for Type 1 Diabetes (ABC4D)
This study aims to assess the safety and efficacy of a novel advanced bolus calculator in subjects with Type 1 diabetes. Insulin bolus calculators have been developed to aid insulin dose adjustment and existing standard insulin…
- Trial name
- ABC4D (NCT02053051)
- Testing
- ABC4D, Standard bolus calculator
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Diabetes Mellitus
Metabolic Phenotypes and Heterogeneity in Disease Burden Risk in Type 1 Diabetes
This study focuses on individuals with type 1 diabetes (T1D) and seeks to comprehensively study and understand several aspects of T1D including: susceptibility to hypoglycemia (low blood sugar) and improvement in hypoglycemia…
- Trial name
- JDRF-COE (NCT05609279)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 1
Diabetic Patients Needs in Therapeutic Education About Work. TE-DIW (Therapeutic Education of DIabetic Working People)
Diabetes mellitus is an important disease around the world and the number of diabetic people increase every day. The type 1 diabetes often occurred in the youth and people have to learn to work with it and its complication.
- Trial name
- ET-DIT (NCT03893266)
- Testing
- Interviews
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus, Type I
Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation After Kidney Transplant
Type 1 diabetes mellitus (T1D) is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00790439
- Testing
- Low Molecular Weight Sulfated Dextran, Heparin, Mycophenolate Mofetil
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Hormone Responses During Hypoglycemia and the Accuracy of Continuous Glucose Monitors
The primary objective of this study will be to compare the glucose level at which counter-regulatory hormone responses occur during hypoglycemia in young children with diabetes, with the glucose level counter regulatory hormone…
- Trial name
- NCT00607139
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Impact of Functional Insulinotherapy on Blood Glucose Variability Indicators in Patients With Type 1 Diabetes
The primary objective of this trial is to assess whether functional insulinotherapy decreases blood glucose variability at 3 months and 6 months, compared to initial values in type 1 diabetes patients.
- Trial name
- VARIAFIT (NCT00973492)
- Testing
- functional insulinotherapy class
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association Grenobloise pour le Developpement D'etudes et de Recherches en Physiopathologie Endocrinienne, Diabetologie et Maladies de la Nutrition
Type1 Diabetes
Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes
Randomized trial of youth aged 7-<18 years with newly diagnosed stage 3 type 1 diabetes (T1D) to assess the effect of both (1) near-normalization of glucose concentrations achieved through use of a hybrid closed loop (HCL) system…
- Trial name
- CLVer (NCT04233034)
- Testing
- HCL, verapamil 120mg tablet, non-HCL
- Where
- 6 sites in United States
- Volunteers
- 113 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Quality of Life
Quality of Life in Pancreas Transplantation
Quality of Life for individuals with Insulin Dependent Diabetes Mellitus (IDDM) can be severely impaired by acute and chronic complications of the disease.
- Trial name
- NCT03921593
- Testing
- Solid Organ Pancreas Transplantation with or without Kidney Transplantation
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Diabetic Ketoacidosis
A Multi-Disciplinary Technology-Based Care for Diabetic Ketoacidosis in Patients With Type 1 Diabetes
The study team proposes that use of a novel multi-disciplinary approach with continuous glucose monitoring technology can significantly improve glycemic control and reduce readmissions among those with type 1 diabetes mellitus…
- Trial name
- DKA (NCT06471322)
- Testing
- Continuous Glucose Monitoring (CGM), Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Type 1 Diabetes Mellitus, Type 1 Diabetes (T1D)
AI-Assisted Remote Insulin Pump Optimization in T1DM
This study evaluates an AI-assisted remote parameter optimization tool for individuals with type 1 diabetes （T1D） using insulin pump and continuous glucose monitoring (CGM).
- Trial name
- NCT07732777
- Testing
- AI-Assisted Insulin Pump Settings Optimization System, Conventional Insulin Pump Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
Patients with diabetes have high blood sugar levels (hyperglycemia) because pancreatic beta-cells no longer produce sufficient insulin.
- Trial name
- NCT00813228
- Testing
- Sitagliptin (Januvia)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1
Psychosocial Factors Affecting Glycemic Control in Children and Adolescents With Type 1 Diabetes Mellitus
The aim of the study is to research psychosocial and socioeconomic factors among families that might affect glycemic control in children and adolescent with type 1 diabetes mellitus.
- Trial name
- NCT04186195
- Where
- Finland
- Volunteers
- 191 people
- Sponsor
- Tampere University Hospital
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate the Safety of Levemir® in Diabetes
This study is conducted in Africa, Asia, Europe, Japan and South America. The aim of this observational study is to evaluate the incidence of serious adverse reactions (SARs) while using Levemir® (insulin detemir) under normal…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PREDICTIVE™ (NCT00659295)
- Testing
- insulin detemir
- Where
- 13 sites in Belgium, Czechia and 11 more
- Volunteers
- 51,170 people
- Sponsor
- Novo Nordisk A/S
Retinal Vascular, Retinal Disease
Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus
This study is directed to evaluate the role of Optical Coherence Tomography Angiography (OCT-A) in the evaluation of the perifoveal vascular network in type 1 diabetic patients, and to investigate the relationship between…
- Conditions
- Retinal Vascular, Retinal Disease, Retinal Ischemia, Retinal Ischaemia Due to Type 1 Diabetes Mellitus
- Trial name
- NCT03422965
- Testing
- Optical Coherence Tomography Angiography, Blood test, Urine test
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Type 1 Diabetes Mellitus
CloudConnect: Predictive And Retrospective Clinical Decision Support For Chronic Disease Management
This study is to assess an approach of self-management called CloudConnect, evaluating the impact of CloudConnect Reports on patient engagement, adolescent/parent discussion, and clinical outcomes in adolescent Type 1 Diabetes…
- Trial name
- NCT03676465
- Testing
- CloudConnect Report, Will not receive a CloudConnect Report
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1, Child
Comparison Between Insulin Pump Treatment and Multiple Daily Insulin Injections in Diabetic Type 1 Children
Comparison between insulin pump treatment and multiple daily insulin injections in 38 children with type 1 diabetes4-16 years old. Outcome metabolic control, quality of life, impact of disease and cost effectiveness.
- Trial name
- NCT00462371
- Testing
- Insulin pump (CSII)
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Type 1 Diabetes
Lipoprotein Kinetics in T1D
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke).
- Trial name
- LTD (NCT05179954)
- Testing
- Metabolic testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes Mellitus, Type 1
AT278 and NovoRapid® in Glucose Clamp Study
A phase 1, randomised, single-centre, double-blind, single-dose, two period balanced cross over study in a glucose clamp setting.
- Trial name
- NCT04660305
- Testing
- AT278, NovoRapid
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Arecor Limited
Kidney Insufficiency, Diabetes Mellitus
Plant Versus Animal Dietary Protein and the Effect on Proteinuria
The purpose of this study is to investigate if a diet high in plant protein improves kidney function in patients with kidney insufficiency and diabetes and/or hypertension and/or glomerulonephritis.
- Conditions
- Kidney Insufficiency, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NYPRO (NCT04058951)
- Testing
- High Animal Protein Diet (HAPD), High Plant Protein Diet (HPPD)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Jens Rikardt Andersen
Type 1 Diabetes
Impact of a built-in Insulin Calculator Feature on Diabetes Control - Pilot Study
The purpose of this study is to investigate the effect of using FreeStyle InsuLinx (a blood glucose meter with a built-in insulin calculator) on glucose control in people with type 1 diabetes.
- Trial name
- NCT01519466
- Testing
- FreeStyle InsuLinx, FreeStyle Freedom Lite
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 55 people
- Sponsor
- Abbott Diabetes Care
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