Clinical trials: Diabetes Type I
Type 1 Diabetes, Hypoglycemia
Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes
Despite recent pharmacological and technological advantages, hypoglycemia remains to be the key limiting factor in achieving optimal glycemic control in people with type 1 diabetes.
- Trial name
- DHCL2019 (NCT04053712)
- Testing
- Glucagon, Closed-loop system
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Mobile Application-delivered Resistance Program for Children and Adolescents With Type 1 Diabetes (Diactive-1)
This project involves a two-arm randomized controlled trial (RCT) designed to assess the feasibility, acceptability, and preliminary efficacy of a mobile application aimed at prescribing resistance training for children and…
- Trial name
- Diactive-1 (NCT06048757)
- Testing
- Diactive-1 application
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Fundacion Miguel Servet
Type 1 Diabetes
Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- NCT01591681
- Testing
- Pump suspension
- Where
- 3 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Jaeb Center for Health Research
Diabetes, Autoimmune
Safety, Tolerability, Immunological and Clinical Efficacy of Multiple Subcutaneous Doses of DiaPep277 in Latent Autoimmune Diabetes in Adults (LADA)
Randomized, double-blind, parallel-group study to evaluate safety and efficacy of multiple subcutaneous doses of DiaPep277 in patients with Latent Autoimmune Diabetes in Adults (LADA).
- Trial name
- NCT00058981
- Testing
- DiaPep277
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- DeveloGen Israel, Ltd.
Diabetes Mellitus, Type 1, Complications
Long Term Vascular Changes in Type 1 Diabetes
The main purpose of this study is to investigate progression of late complications of diabetes during the last ten years in a well characterized cohort of type 1 diabetes with a long duration of the disease, and to define factors…
- Conditions
- Diabetes Mellitus, Type 1, Complications, Coronary Heart Disease
- Trial name
- DM09 (NCT00991575)
- Where
- Norway
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Type 1 Diabetes, Hypoglycemia
hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients
The collective effects of two-layer pancreas preservation, pretransplant islet culture, day -2 pretransplant immunosuppression, and induction immunosuppression with the FcR-nonbinding anti-CD3 monoclonal antibody hOKT3γ1…
- Trial name
- NCT00285194
- Testing
- Allogeneic Islets of Langerhans, hOKT3γ1 (Ala-Ala)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetic Macular Edema (DME)
High Dose Aflibercept in Diabetic Macular Edema in Patients With Previous Vitrectomy
Patients with diabetic macular edema (DME) sometimes must undergo vitrectomy surgery (PPV) for diabetic and non-diabetic related issues.
- Trial name
- NCT06662994
- Testing
- Aflibercept 8 mg (VEGF Trap-Eye, BAY86-5321)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Retina Consultants of Orange County
Diabetes Mellitus, Type 1
A Clinical Study to Investigate and Compare the Impact of High Protein Pasta, Lower Protein Pasta and White Rice on Blood Sugar Control in People With Type 1 Diabetes Mellitus (T1DM)
The aim of this clinical study is to investigate and compare the postprandial glycemic response to three different meal types rich in carbohydrates, that is, white pasta, high protein pasta and white rice consumed by individuals…
- Trial name
- NCT03362151
- Testing
- Regular pasta, High protein pasta, White rice
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Cross-Sectional Study
Glycaemic control is an important aspect of Type 1 diabetes (T1D) management for diabetologists and patients alike. Evidence suggests continuous subcutaneous insulin infusion (CSII) is an effective method of achieving this.
- Trial name
- NCT02258945
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Liverpool John Moores University
Diabetes Mellitus
Evaluation of the Accuracy of an Implanted Glucose Sensor
The purpose of this clinical investigation is to evaluate the accuracy of the Senseonics Continuous Glucose Monitoring System (Senseonics CGM System) measurements when compared with reference standard measurements The…
- Trial name
- PRECISEII (NCT02647905)
- Testing
- Continuous Glucose Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 90 people
- Sponsor
- Senseonics, Inc.
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes: Evaluation of Reduced Meal Bolusing
The main focus of our research is the development of a closed-loop system for glucose control in people with type 1 diabetes. After having demonstrated the safety and efficacy of overnight closed-loop insulin delivery, we are…
- Trial name
- NCT01629251
- Testing
- Closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
Assessing Closed-loop Insulin Delivery in Children With Type 1 Diabetes.
The objective of this clinical trial is to assess the safety of our insulin dosing algorithm in children with type 1 diabetes in a free-living study.
- Trial name
- NCT04612257
- Testing
- Insulin-alone closed-loop
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
The procurement of blood for SMBG, usually via a finger stick, is considered by many patients to be the most painful portion of diabetes therapy.
- Trial name
- NCT00741390
- Testing
- BD/33G, OTM / 33G, OTU/28G
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Becton, Dickinson and Company
Type I Diabetes
Ladarixin as Adjunctive Therapy to Improve Insulin Sensitivity and Glucometabolic Outcomes in Type 1 Diabetes
Objectives Primary study objective: To determine whether orally-administered ladarixin versus placebo adjunctive therapy improves insulin sensitivity in overweight, insulin-resistant (IR) type 1 Diabetic (T1D) adult subjects.
- Trial name
- NCT05035368
- Testing
- Ladarixin
- Where
- United States
- Sponsor
- Dompé Farmaceutici S.p.A
Type 1 Diabetes
Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia
The main purpose of the study is to determine the effects of 16 weeks of adjunctive pramlintide or exenatide use on glycemic control in Type 1 Diabetes.
- Trial name
- NCT01269047
- Testing
- Pramlintide, Exenatide, Insulin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Diabetes Mellitus, Type 1
An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D
This is an open-label, multicenter, Phase 1 study evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects with T1D
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05565248
- Testing
- VCTX211
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- CRISPR Therapeutics AG
Type 1 Diabetes
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable…
- Trial name
- R2D2 (NCT05268250)
- Testing
- R2D2 mHealth intervention
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Pharmacodynamics, Pharmacokinetics, and Safety of ASP1941 in Patients With Type 1 Diabetes Mellitus
The objective of this study is to assess pharmacodynamics, pharmacokinetics, and safety of ASP1941 in patients with type 1 diabetes mellitus when administered once daily (q.d.) for 2 weeks.
- Trial name
- NCT02529449
- Testing
- ASP1941
- Where
- 11 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Astellas Pharma Inc
Type 1 Diabetes, Diabetes Distress
Behavioral Approaches to Reducing Diabetes Distress and Improving Glycemic Control
This study is comparing three programs to reduce Diabetes Distress (the worries and concerns that people with diabetes may experience as they struggle to keep blood glucose levels in range) in adults with type 1 diabetes.
- Trial name
- EMBARK (NCT04016558)
- Testing
- StreamLine, TunedIn, FixIt
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of California, San Francisco
Hypoglycemia, Diabetes Mellitus, Type 1
A Pilot Study of Nocturnal Hypoglycemia Prevention in Type 1 Diabetes Using the Vigilant Diabetes Management Companion
A single center pilot study assessing the Vigilant Diabetes Management Companion for the prevention of recurrent nocturnal hypoglycemia in type I diabetes patients.
- Trial name
- NCT02906891
- Testing
- Vigilant Diabetes Management Application
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- InSpark Technologies, Inc.
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