Clinical trials: Diabetes Type I
Type 1 Diabetes
Intervention for Children With Type 1 Diabetes Targeting Gut Microbes
The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes.
- Trial name
- TRIM1 (NCT06198725)
- Testing
- Trimtab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 1
EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
The objectives of this study is to: Evaluate the tolerability of a combination therapy with Diamyd, vitamin D and etanercept Evaluate how the above mentioned treatments influence the immune system and endogenous insulin secretion
- Trial name
- NCT02464033
- Testing
- GAD-Alum, Vitamin D, Etanercept
- Where
- 8 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Johnny Ludvigsson
Diabetes
A Comparison Study of Prototype Continuous Glucose Sensors in the Intradermal and Subcutaneous Spaces
The purpose of this study is to compare two continuous glucose sensors, one placed subcutaneous (under the skin) and one placed intradermal (in the skin) over 12-14 hours.
- Trial name
- NCT01093833
- Testing
- BD Continuous glucose monitor (BD CGM), YSI Glucose Analyzer, Medtronic Guardian CGM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Becton, Dickinson and Company
Diabetes Mellitus, Type 1
Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
This proposed study will test whether measurement of breath acetone (BrAce) can be used for the purpose of identifying ketosis (elevated ketones) in persons with type 1 diabetes (T1D).
- Trial name
- NCT05541484
- Testing
- SGLT2 inhibitor, Biosense Breath Ketone Analyzer
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Diabetes, Diabetes Mellitus, Type 1
Human Insulin NPH and Insulin Aspart in Type 1 Diabetes
This trial is conducted in South America. This aim of this trial is to evaluate the comparative prandial blood glucose lowering profile in subjects with type 1 diabetes.
- Trial name
- NCT00597233
- Testing
- insulin aspart, soluble human insulin, insulin NPH
- Where
- Argentina
- Volunteers
- 91 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus
The purpose of this study is to determine wether coenzyme Q10 is effective in reducing markers of endothelial dysfunction in pediatric patients with type 1 diabetes mellitus and aslo to investigate its effect on glycemic control…
- Trial name
- NCT03111433
- Testing
- Coenzyme Q10, Insulin
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Ain Shams University
Type1diabetes
Safety of Closed-loop Hybrid Insulin Administration During Ramadan Fasting in People Living With Type 1 Diabetes
Fasting in Ramadan is not recommended for people with type 1 diabetes. The main risk associated with fasting is dysglycemia (hypoglycemia, hyperglycemia, diabetic ketosis) and dehydration.
- Trial name
- RAMDAM (NCT05747352)
- Testing
- closed-loop hybrid insulin administration
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 1 Diabetes, Hyperglycemia Stress
Competition Induced Hyperglycemia in Athletes With Type 1 Diabetes
Design and methods 12 athletes with T1D and 12 healthy athletes are included in a prospective experimental randomized, cross-over study.
- Trial name
- EXCITE-1 (NCT05561517)
- Testing
- 5 K running
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes Mellitus
Beta Cell Imaging During and Shortly After the Honeymoon Phase of T1D
The primary goal is to correlate beta cell mass to beta cell function from measurements during and shortly after the honeymoon phase of type 1 diabetes, to improve understanding of the change in metabolic control after the…
- Trial name
- Honeymoon (NCT03917238)
- Testing
- gallium-68-exendin injection followed by PET/CT scan
- Where
- 2 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- Radboud University Medical Center
Glucose Lowering
To Assess the Pharmacokinetics of AZD1656 and Its Metabolite in Type 2 Diabetes Mellitus Patients
To assess the pharmacokinetics of AZD1656, and its metabolite, in type 2 diabetes mellitus patients with varying degrees of renal impairment and to compare the results with those in patients with normal renal function.
- Trial name
- NCT01069926
- Testing
- AZD1656
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- AstraZeneca
Diabetes, Diabetic Foot
Optimized Care of People With Diabetes and Foot Complication in Primary Care
The goal of this observational study is to create and evaluate and new management, by using eHealth tools, to prevent diabetic foot ulcers. The main questions it aims to answer are: 1. Validation a.
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Diabetes Mellitus, Type 2
- Trial name
- NCT05692778
- Testing
- Patients being foot examined by using an eHealth tool, Patients being foot examined in traditional manner
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Sahlgrenska University Hospital
Diabetes Mellitus, Type 1
Sulfonylurea Effects on Glucagon Regulation During Hypoglycemia in Type 1 DM
We aim to demonstrate that oral administration of glibenclamide stimulates pancreatic glucagon secretion during hypoglycemia in insulin-deficient (C-peptide negative) patients with type 1 diabetes when compared to type 1 diabetic…
- Trial name
- NCT00515801
- Testing
- glibenclamide
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus, Type 1
Prolonged Remission Induced by Phenofibrate in Children Newly Diagnosed With Type 1 Diabetes.
The goal of this clinical trial is to evaluate of the effect of phenofibrate on the functions of beta cells in children with new diagnosis of type 1 diabetes.
- Trial name
- PRIFEN (NCT05909800)
- Testing
- Phenofibrate
- Where
- 2 sites in Poland
- Volunteers
- 102 people
- Sponsor
- Medical University of Warsaw
Type 1 Diabetes
Impact of Food Carbohydrate and Insulin Dose Computing by on Smart Phone on Glucose Control in Patients With Diabetes
During this study, we will assess a new smart phone application which aims at helping patients with Type 1 diabetes to compute food carbohydrates and meal insulin doses.
- Trial name
- GLUCAL (NCT02676609)
- Testing
- Automated carbohydrate and meal insulin dose computing
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes
Use of Insulin Adjustment Device DreaMed Advisor Pro During Routine Clinical Use for Subjects With Diabetes Type 1
The DreaMed Advisor Pro, is a software which automatically analyses treatment information, learns patient's needs and accordingly suggests adjustments in insulin dosing (FDA approved decision support system).
- Trial name
- NCT04271228
- Testing
- DreaMed Advisor Pro
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus Type 1 Pre-Existing, Pregnancy Related
Closed-Loop Insulin in Mothers With Type 1 Diabetes and Baby Feeding Practices
This study will is a parallel two-group randomized controlled trial that will use the MiniMed 670G hybrid closed-loop system's continuous glucose monitor (GCM) insulin pump and computer algorithm to deliver insulin when in "auto…
- Conditions
- Diabetes Mellitus Type 1 Pre-Existing, Pregnancy Related, Feeding Behavior, Infant Development
- Trial name
- CLIMB (NCT04420728)
- Testing
- Early auto-mode, Delayed auto mode
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Diabetes Mellitus, Type 1
Imaging Inflammation in Autoimmune Diabetes
The purpose of this study is to determine whether magnetic resonance imaging (MRI) with ferumoxtran-10 can be used to detect changes in the pancreas associated with autoimmune diabetes.
- Trial name
- NCT00585936
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes
Islet Allotransplantation in Type 1 Diabetes
Islet transplantation can provide physiologic insulin replacement to patients with type 1 diabetes without the complications associated with whole pancreas transplantation.
- Trial name
- NCT01705899
- Testing
- Human Pancreatic Islets
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Type 1 Diabetes Mellitus
Structured Carbohydrate-Counting Education in Adults With Type 1 Diabetes
This study evaluated changes in glycemic outcomes following a structured carbohydrate-counting education program in adults with type 1 diabetes using continuous glucose monitoring (CGM).
- Trial name
- NCT07834801
- Testing
- Carbohydrate counting education
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Acibadem University
Diabetes Mellitus
The Guardcontrol Trial: Study to Assess if Type 1 Diabetics Can Improve Using the Real-time Values of Guardian RT
The objective of the study is to determine whether patients with poor glycemic control can improve metabolic control using the real-time values of the Guardian® RT compared to conventional self-monitoring blood glucose…
- Trial name
- NCT00111228
- Testing
- Guardian RT, SMBG only
- Where
- 8 sites in France, Germany and 5 more
- Volunteers
- 162 people
- Sponsor
- Medtronic MiniMed, Inc.
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