Clinical trials: Diabetes Type I
Diabetic Neuropathy, Cognitive Impairment
Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus
Given that the tocotrienols have been shown to possess neuroprotective effects and that both type 1 and type 2 diabetes can lead to peripheral neuropathy and cognitive impairment, the present study aims to determine the…
- Trial name
- VENUS (NCT01973400)
- Testing
- Tocotrienol
- Where
- Malaysia
- Volunteers
- 300 people
- Sponsor
- Universiti Sains Malaysia
Diabetes
Multi-day (3) In-patient Evaluation of Intradermal Versus Subcutaneous Basal and Bolus Insulin Infusion
The primary objective of this study is to investigate if intradermal (in the skin) basal and bolus insulin delivery of a fast acting insulin analog (NovoRapid) as needed to adequately control the blood glucose for a subject with…
- Trial name
- NCT01557907
- Testing
- Subcutaneous delivery via Medtronic Quick-Set, Intradermal delivery via the BD Research Catheter Set
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Becton, Dickinson and Company
Thromboelastography, Coagulation; Fetus or Newborn
Thromboelastographic Profile in Healthy Newborns and Infants of Diabetic Mothers Using TEG6s
Thromboelastography (TEG) is a laboratory technique used to examine the process of clot formation and degradation by measuring and reporting the kinetic changes, the rate of clot formation, clot strength, and clot stability.
- Conditions
- Thromboelastography, Coagulation; Fetus or Newborn, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT04917965
- Testing
- Laboratory clotting studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Diabetes, Diabetes Mellitus, Type 1
Efficacy and the Safety of Insulin Detemir in Subjects With Insulin Requiring Diabetes
This trial is conducted in Japan. The aim of this trial is to investigate the efficacy of insulin detemir on blood glucose control in subjects with insulin requiring diabetes.
- Trial name
- NCT00604344
- Testing
- insulin detemir, insulin NPH
- Where
- Japan
- Volunteers
- 401 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Insulin-Dependent
Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children and Adolescents
The purpose of this study is to determine if insulin glulisine (Apidra) is as safe and effective a rapid acting insulin as insulin lispro (Humalog) in children and adolescents with type 1 diabetes mellitus.
- Trial name
- NCT00115570
- Testing
- Insulin glulisine, insulin lispro, insulin glargine
- Where
- United States
- Volunteers
- 572 people
- Sponsor
- Sanofi
Fasting Hypoglycemia, Diabetes Mellitus, Type 1
Mini-Dose Glucagon to Treat Fasting-induced Hypoglycemia During Ramadan
This study aimed to develop a new approach for the treatment of fasting induced hypoglycemia during ramadan using mini-dose glucagon.
- Trial name
- NCT03970772
- Testing
- Glucagon Injection, Glucose Tablets
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- Qassim University
Telemedicine
Telemedicine on Metabolic Control in Type 1 Diabetes Mellitus Andalusian Patients (PLATEDIAN)
To assess the effect of a 6-month telemedicine program (DiabeTIC) in patients with type 1 diabetes mellitus (DM1) and regular metabolic control (HbA1c <8%) in multi-dose insulin treatment (MDI) measured HbA1c vs.
- Trial name
- PLATEDIAN (NCT03332472)
- Testing
- Telemedicine group, Conventional group
- Where
- Spain
- Volunteers
- 334 people
- Sponsor
- Sociedad Andaluza de Endocrinología, Diabetes y Nutrición
Type 1 Diabetes, Hypoglycemia
Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus
The purpose of this study is to determine whether ZT-01 increases the glucagon response to hypoglycemia in type 1 diabetes (T1D).
- Trial name
- NCT05007977
- Testing
- ZT-01 low dose, ZT-01 high dose
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Zucara Therapeutics Inc.
Stress, Type 1 Diabetes
Glycemic Rises After Waking Up In Response To An Alarm Clock In Type 1-Diabetic Patients Analysed With Continuous Glucose Monitoring (GlucoDay®)
Study hypothesis: Waking up in response to an alarm clock may evoke a stress reaction that leads to rising glucose concentrations.
- Trial name
- NCT00740012
- Testing
- Continuous glucose monitoring, alarm- clock intervention, patient perform blood glucose self monitoring, nurse intervention
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz
Injection Pain Prevention
Shot Blocker and Manual Pressure Application
Aim of my intervention to test the effectiveness of using the manual pressure application and shotblocker for relief insulin injection pain in children with type 1 diabetes mellitus
- Trial name
- NCT07407881
- Testing
- Manual pressure applied at injection site during insulin injection to reduce pain, Shotblocker, Control group stander care
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Type 1 Diabetes
A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes
The main purpose of this study is to evaluate the safety and tolerability of a study drug called nasal glucagon (Baqsimi) in pediatric participants with type 1 diabetes (T1D) aged 1 to less than 4 years.
- Trial name
- RescuiNGkids (NCT04992312)
- Testing
- Glucagon Nasal Powder [Baqsimi]
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
Safety and Efficacy of Autologous Adipose-Derived Stem Cell Transplantation in Type 2 Diabetics
The purpose of this study is to determine whether intravenous administration of autologous adipose-derived stem cells is of benefit in the management of types 2 diabetics.
- Trial name
- NCT00703612
- Testing
- Autologous Adipose-derived Stem cells
- Where
- 2 sites in Philippines
- Volunteers
- 34 people
- Sponsor
- Adistem Ltd
Type 1 Diabetes Mellitus
Prevention of Hypoglycaemia With Predictive Insulin Suspend Using Sensor Augmented Insulin Pump in Children
The aim of the study is to prove whether the use of the SmartGuard feature of the MiniMed system significantly reduces hypoglycemic excursions and thus provide proactive protection to the user.
- Trial name
- SportGuard (NCT02179281)
- Testing
- Medtronic MiniMed™ 640G system
- Where
- 2 sites in Israel, Slovenia
- Volunteers
- 100 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Insulin Dependent Diabetes Mellitus
Strategies to Minimize the Risk for Insulin Induced Hypertrophy and Its Related Consequences
Hypertrophy caused by insulin has effects that extend beyond just aesthetic concerns. Innovative methods have shown potential in decreasing the chances of hypertrophy and its related issues, including the development of detailed…
- Trial name
- NCT07375875
- Testing
- Group(1) Insulin site injection map
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Mansoura University
Type 1 Diabetes
The ADHERENCE Index - the Indicator of Effective Coping With the Requirements of the Disease of Children and Adolescents With Type 1 Diabetes
The aim of the research is to develop a mathematical model called ADHERENCE index, and to evaluate its effectiveness.
- Trial name
- ADHERENCE (NCT01580462)
- Testing
- Observational study
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Diabetes Mellitus, Type 1
Extension of Phase II Therapeutic Trial With a Humanized Non-Mitogenic CD3 (ChAgly CD3) Monoclonal Antibody in Recently Diagnosed Type 1 Diabetic Patients
Compared to placebo, treatment with ChAgly CD3 has a beneficial effect on preservation of beta cell function and metabolic outcome in type 1 diabetic patients with recent clinical onset of disease that persists until 48 months…
- Trial name
- NCT00627146
- Testing
- ChAgly CD3
- Where
- 5 sites in Belgium, Germany
- Volunteers
- 80 people
- Sponsor
- Universitair Ziekenhuis Brussel
Type 1 Diabetes
Overnight Closed Loop Study in U.S.
This is a multicenter feasibility study. Up to 85 subjects will be enrolled in the study. The goal of the study is to demonstrate that the Hybrid Closed Loop (HCL) System is safe to be used in an even larger study outside of…
- Trial name
- OCL (NCT01857973)
- Testing
- Hybrid Closed Loop
- Where
- 6 sites in United States
- Volunteers
- 78 people
- Sponsor
- Medtronic MiniMed, Inc.
Wolfram Syndrome 1, Optic Atrophies, Hereditary
Does Recessive Optic Atrophy Due to WFS1 Exist?
All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study.
- Trial name
- NCT07336966
- Testing
- analyse study
- Volunteers
- 45 people
- Sponsor
- Hôpital Necker-Enfants Malades
Diabetes Mellitus, Metabolic Surgery
Metabolic Surgery; Gastric Bypass vs Sleeve Gastrectomy; Efects Over Type 2 DM With Bad Metabolic Control (MSO1CT)
The aim of the study is to compare the efficacy of laparoscopic gastric bypass versus vertical gastrectomy for the resolution of DM in patients with BMI 30-35.
- Conditions
- Diabetes Mellitus, Metabolic Surgery, Sleeve Gastrectomy, BPGY
- Trial name
- MSO1CT (NCT03891056)
- Testing
- metabolic surgery
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario Doctor Peset
Acute Pancreatitis
Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics
The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop…
- Trial name
- DREAM-ON (NCT06401577)
- Testing
- Dexcom Continuous Glucose Monitor (CGM)
- Where
- 13 sites in United States
- Volunteers
- 800 people
- Sponsor
- Milton S. Hershey Medical Center
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