Clinical trials: Diabetes Type I
Type 1 Diabetes, Diabetes in Children
The T1D Parent Check-In: A Preventative Intervention
The goal of this clinical trial is to learn how to best support families during the first year of a child or teen's Type 1 diabetes (T1D) diagnosis.
- Trial name
- NCT06160934
- Testing
- T1D Parent Check-in
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Gastroparesis, Type 1 Diabetes
Automated Insulin Delivery in Type 1 Diabetes Complicated by Gastroparesis
This is a staggered randomised controlled trial that aims to assess the impact of an automated insulin delivery (AID) system on glucose, gastrointestinal and patient-reported outcomes.
- Trial name
- AIDgastro (NCT05795309)
- Testing
- Hybrid Automated Insulin Delivery
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 1
To Compare Influence of Breakfast With and Without Sweeteners on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes
Introduction: Type 1 diabetes is a chronic autoimmune disease with multifactorial etiology, resulting in partial or complete destruction of pancreatic β cells, leading to an absolute deficit of insulin and vital dependence on…
- Trial name
- T1D (NCT06201806)
- Testing
- Test food breakfast with NCS or witout NCS
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- University of Chile
Type 1 Diabetes Mellitus
Basic Hematological Parameters and Coagulation Profile in Type 1 Diabetic Children
Diabetes mellitus is a group of chronic metabolic diseases characterized by hyperglycemia .Type 1 diabetes is a heterogeneous disease related to the destruction of pancreatic beta cells and is a result of absolute lack of insulin…
- Trial name
- NCT06897904
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes
Immunointervention With Calcitriol in New-Onset Type 1 Diabetes
This is a randomized, two-arm, placebo-controlled phase-2 trial to determine whether the daily intake of 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3], improves beta cell function in patients with recently diagnosed type 1 diabetes.
- Trial name
- NCT00960635
- Testing
- 1,25-dihydroxy-vitamin D3 (calcitriol)
- Where
- Germany
- Sponsor
- Institut fur Diabetesforschung, Munich, Germany
Type 1 Diabetes Mellitus
Molecular Quantification of Insulin mRNA
The objectives of this study are to: 1. quantitate the level of insulin mRNA in the while cell fraction of whole blood in selected groups of subjects, 2.
- Trial name
- NCT00324207
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Type 1 Diabetes Mellitus
A Qualitative Study on CSII in Children and Adolescents Having Type 1 Diabetes
Using qualitative method; a qualitative case study using semi-structured interviews to explore patients' experiences. Study population of insulin pump patients aged 11-18 years old will be recruited from pediatrics with T1D at…
- Trial name
- NCT03066284
- Where
- Kuwait
- Volunteers
- 20 people
- Sponsor
- Dasman Diabetes Institute
Diabetes Mellitus, Type 1
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes
This is a Phase 3 trial of cadisegliatin as adjunctive therapy to insulin in participants with Type 1 Diabetes Mellitus.
- Trial name
- CATT1 (NCT06334133)
- Testing
- Cadisegliatin 800 mg QD, Cadisegliatin 800 mg BID
- Where
- 48 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- vTv Therapeutics
Type1diabetes
Family-Based Behavioral Medical Nutrition Therapy Education in Children and Adolescents With Type 1 Diabetes
Type 1 Diabetes Mellitus (T1DM) is a heterogeneous condition and is an absolute insulin deficiency resulting from autoimmune-mediated destruction of pancreatic β-cells (1).
- Trial name
- NCT05411952
- Testing
- Medical nutrition therapy and carbohydrate counting education, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Hasan Kalyoncu University
Metastatic Melanoma
Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic Melanoma
Our proposed study is designed to test the safety of a new vaccine against melanoma. The induction of immune activity against cancers such as melanoma is a promising approach to cancer treatment, but to date, only a few…
- Trial name
- NCT01216436
- Testing
- Vaccination with RNA-transfected mature autologous DC
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Diabetes
The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies
Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed…
- Trial name
- NCT06173934
- Testing
- insulin injection 15 minutes before meals, Insulin injection 15 minutes after eating
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type1diabetes
Mobile Physical Activity for Type 1 Diabetes
The study is the formative observation stage of behavioral intervention development. Sedentary adults with type 1 diabetes will be given access to a mobile application that incorporates biosensor feedback, teleconsultation, and…
- Trial name
- NCT04204733
- Testing
- Mobile application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Obesity
On-Line Intervention For Promoting Healthy Habits And Weight Loss In Hypertensive Patients
Efficacy of an Internet-based self-guided intervention for promoting healthy habits and weight loss in hypertensive people with overweight and obesity: A Randomized Controlled Trial
- Trial name
- VIVIR-MEJOR (NCT02445833)
- Testing
- Lifestyle on-line intervention
- Volunteers
- 106 people
- Sponsor
- Universitat Jaume I
Type One Diabetes
The Safety and Efficacy of Administrating DiaPep277® Vaccination in Type 1 Diabetes Patients.
Type 1 diabetes is caused by an autoimmune process resulting in a selective destruction of the pancreatic insulin-secreting beta-cell. DiaPep277® is a small, lyophilized powder containing 24 Amino-acids.
- Trial name
- NCT01881958
- Testing
- DiaPep277®
- Sponsor
- Hadassah Medical Organization
Type 1 Diabetes
Family Routines Enhancing Adolescent Diabetes by Optimizing Management
A three month randomized study to examine the potential benefits of sleep extension in tandem with clinical trial on diabetes management in youth with type 1 diabetes.
- Trial name
- FREADOM (NCT02974309)
- Testing
- Sleep Extension, Routine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
Type 1 Diabetes
Timing of Resistance Exercise in Type 1 Diabetes
The aims of the current study are 1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes. 2.
- Trial name
- T-REX (NCT05884814)
- Testing
- Morning exercise, Afternoon exercise, Habitual physical activity levels
- Where
- Kuwait
- Volunteers
- 54 people
- Sponsor
- Dasman Diabetes Institute
Advanced Solid Tumor
CTLA-4 and PD-1 Antibodies Expressing EGFR-CAR-T Cells for EGFR Positive Advanced Solid Tumor
This is a single-arm, open-label, one center clinical study, to determine the safety and efficacy of infusion of autologous T cells engineered to express immune checkpoint antibodies (CTLA-4 and PD-1) and chimeric antigen…
- Trial name
- NCT03182816
- Testing
- anti-CTLA-4/PD-1 expressing EGFR-CAR-T
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Cell Therapy Research Institute
Lung Adenocarcinoma
PHOENIX: QL1706 Plus Chemotherapy and Bevacizumab in AGA-Resistant, PD-L1 ≥50% Non-Squamous NSCLC
The goal of this Phase II clinical trial (The PHOENIX Study) is to evaluate if the combination of QL1706 (Iparomlimab and Tuvonralimab), bevacizumab, and chemotherapy can treat patients with TKI-refractory, driver-gene positive…
- Trial name
- PHOENIX (NCT07416058)
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Guangdong Association of Clinical Trials
Diabetes Mellitus, Diabetes Mellitus, Type 1
An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
This study is conducted in Europe and Asia. The purpose of the study (Diabetes Pregnancy Registry) is to evaluate the safety of treatment with insulin detemir in pregnant women with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01892319
- Testing
- insulin detemir, other injectable antidiabetic treatment regimens
- Where
- 93 sites in Croatia, Finland and 14 more
- Volunteers
- 2,446 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity
The main purpose of this study is to learn more how tirzepatide affects stomach emptying in participants with Type 1 Diabetes Mellitus (T1DM) and overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 1, Overweight, Obesity
- Trial name
- NCT07803744
- Testing
- Tirzepatide, Acetaminophen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eli Lilly and Company