Clinical trials: Diabetes in Adolescence
Type 1 Diabetes Mellitus
Comparing the Metabolic Control of Once to Twice-daily Insulin Detemir Injections
An open-label, treat to target, intervention study in order to compare the metabolic control of once to twice-daily insulin Detemir injections in children and adolescence with type 1 diabetes mellitus.
- Trial name
- NCT00542399
- Testing
- Levemir (insulin detemir), Levemir twice a day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Type1diabetes, Cardiovascular Risk Factor
Increasing Heart Healthy Behaviors in Youth With Type 1 Diabetes
This study is evaluating how to encourage teens to engage in heart healthy behaviors such as being more active or eating in a healthy way.
- Trial name
- NCT03531021
- Testing
- Heart healthy intervention
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes, Hypoglycemia
Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes
In this within-subject cross-over study, the investigators hypothesize that corn-starch based supplements taken prior to exercise will decrease the risk of delayed hypoglycemia in adolescents with T1D, improve performance during…
- Trial name
- NCT05540132
- Testing
- maltodextrin, super starch
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Type 1 Diabetes
Optimizing Self-Management Adherence and Glycemic Control in Older Teens With Type 1 Diabetes: The Teenwork Study
The purpose of this 18-month randomized controlled trial (RCT) is to find out if (1) a set of psychoeducational materials for teens with type 1 diabetes and (2) text message reminders to check blood glucose levels can help…
- Trial name
- NCT01892280
- Testing
- Teenwork intervention, Text message reminders
- Where
- 2 sites in United States
- Volunteers
- 310 people
- Sponsor
- Joslin Diabetes Center
Type1diabetes
Increasing Use of Continuous Glucose Monitors in Publicly-insured Youth With Type 1 Diabetes
To use an enhanced continuous glucose monitor (CGM) experience, including an automated CGM-electronic health record (EHR) data integration system, proactive interventions, and gamification techniques, to increase CGM use among…
- Trial name
- NCT03297762
- Testing
- gamification, Use of Dexcom G5
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Type 1 Diabetes
Better Control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference (SWEET- Registry)
SWEET-REGISTRY is a multi center, investigator initiated registry in patients with diabetes. SWEET' is an acronym derived from 'Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference'.
- Trial name
- SWEET (NCT04427189)
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes
Hybrid Closed Loop in High Risk Youth With Type 1 Diabetes
The use of insulin pumps and continuous glucose monitors for Type 1 diabetes (T1D) has been shown to improve glycemic control while also decreasing the risk for acute and chronic complications.
- Trial name
- NCT04807374
- Testing
- Control IQ
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's National Research Institute
Type 2 Diabetes
Precision Dosing of Metformin in Youth With T2D
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
- Trial name
- PRECISE_T2D (NCT06120881)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Type 1
EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
The objectives of this study is to: Evaluate the tolerability of a combination therapy with Diamyd, vitamin D and etanercept Evaluate how the above mentioned treatments influence the immune system and endogenous insulin secretion
- Trial name
- NCT02464033
- Testing
- GAD-Alum, Vitamin D, Etanercept
- Where
- 8 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Johnny Ludvigsson
Diabetes Mellitus, Diabetes Mellitus, Type 1
Closing the Loop in Children and Adolescents With Type 1 Diabetes in the Home Setting
Type 1 diabetes (T1D) is one of the most common chronic childhood diseases requiring lifelong insulin therapy. Children and adolescents with T1D need regular insulin injections or the continuous insulin delivery using an insulin…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam08 (NCT01778348)
- Testing
- Overnight closed-loop, Real-time CGM alone
- Where
- 3 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Cambridge
Type 2 Diabetes, Proteinuria
Improving Renal Complications in Adolescents With Type 2 Diabetes Through REsearch Cohort Study (National iCARE Study)
The overall aim of the project is to elucidate the primary bio-psycho-social (BPS) risk factors for albuminuria in youth with type 2 diabetes (T2D) and the mechanisms by which they cause renal injury. The Study aims include: 1.
- Conditions
- Type 2 Diabetes, Proteinuria, Stress, Nephropathy
- Trial name
- iCARE (NCT02818192)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Manitoba
Type 1 Diabetes Mellitus, Adolescent
Effect of High Fat High Protein Meal in Type 1 Diabetes
Aim: Despite optimal glycemic control in individuals with type 1 diabetes, post-meal hyperglycemia remains a clinical challenge, and it has been identified as an independent risk factor for the development of long-term…
- Trial name
- T1DM-HFHP (NCT07158385)
- Testing
- Standard test meal (SM), High fat high protein meal-carbohydrate counting (HFHP), High fat high protein meal-fat counting (HFHP-a)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Cumhuriyet University
Type 1 Diabetes Mellitus
A Hybrid Effectiveness-implementation Trial to Reduce Diabetes Distress in Teenagers
The investigators will assess both effectiveness (primary) and implementation (secondary) outcomes for a distress-reducing intervention, Supporting Teen Problem Solving (STePS). STePS has already undergone an efficacy trial.
- Trial name
- NCT06709755
- Testing
- Supporting Teen Problem Solving, Diabetes Education
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Jill Weissberg-Benchell, Ph.D.
Gestational Diabetes Mellitus
Supporting American Indian/Alaska Native Mothers and Daughters in Reducing Gestational Diabetes Risk
The purpose of this study is to modify an existing Reproductive Health intervention for adolescents with diabetes for Gestational Diabetes and make it culturally appropriate American Indian/Alaska Native adolescents.
- Trial name
- NCT02723266
- Testing
- STOPPING-GDM
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes
Alpha-lipoic Acid in Diabetic Nephropathy
Endothelial dysfunction in diabetes is a central event in the pathogenesis of different microangioapthic changes. Nephropathy in patients with type 1 diabetes is a severe microvascular complication.
- Trial name
- NCT06253429
- Testing
- Thioctic Acid 333 MG Oral Capsule, Captopril 25Mg Tab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Type 1 Diabetes, Insufficient Sleep
Assessment of Sleep and Sleep Disruptors in Adolescents With Type 1 Diabetes
The goal of this study is to identify causes of insufficient sleep and sleep disruptors in adolescents with type 1 diabetes. For this study, adolescents will wear an actigraphy watch and complete sleep diaries for seven days.
- Trial name
- NCT05370339
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes Mellitus
A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes
The reason for this study is to compare the study drug LY900014 to insulin lispro (Humalog) in children and adolescents with type 1 diabetes (T1D).
- Trial name
- PRONTO-Peds (NCT03740919)
- Testing
- LY900014, Insulin Lispro, Insulin Glargine
- Where
- 111 sites in United States, Austria and 16 more
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Diseases, Diabetes Mellitus
CV Disease in Adolescents With Type 2 Diabetes
To study cardiac and vascular structure and function in a population of adolescents with type 2 diabetes mellitus (T2DM) compared to a similar group with obesity alone and a similar non-obese group.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Heart Diseases, Obesity
- Trial name
- NCT00114998
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetes Mellitus, Type 2
Glucose Homeostasis and Incretin Effect T2DM in the Youth- a Study of the Malaysian Population
Early onset type 2 diabetes mellitus among adolescents/youth (YT2DM) is a rising phenomenon. The pathophysiology has been studied primarily on non-Asian populations while literature on incretin effect is scarce.
- Trial name
- NCT02845557
- Testing
- OGTT and IVGTT tests
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RCSI & UCD Malaysia Campus