Clinical trials: Diabetes in Adolescence
Type 1 Diabetes Mellitus
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
It has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise.
- Trial name
- NCT03349489
- Testing
- Exercise 1, Exercise 2, Dexcom G4 Platinum
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Children and Adolescents With Type 1 Diabetes Mellitus
The Association Between Diabetes Stress, Self-efficacy, Self-management, and Glycemic Control in Children and Adolescents With Type 1 Diabetes Mellitus
The aims of this study were to: (1) Investigate the association between perceived diabetes-specific stress, self-efficacy, self-management and glycemic control in children and adolescents with type 1 diabetes mellitus (T1D).
- Trial name
- NCT05666791
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Obesity, Overweight
Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus
This study will determine whether resting beta cells (cells in the pancreas that produce insulin) for 2 weeks will improve the ability of patients with Type 2 diabetes mellitus (T2DM) to make insulin.
- Conditions
- Obesity, Overweight, Diabetes Mellitus, Type 2
- Trial name
- NCT00445627
- Testing
- Metformin, Insulin, Nutrition counseling
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus
Aerobic Exercise on Fitness Score and Blood Glucose Level in Adolescents Girls With Diabetes Mellitus
In adolescent diabetic girls, a correct life style, including diet and physical activity, is part of a correct intervention protocol.
- Trial name
- NCT06139913
- Testing
- aerobic exercise
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MTI University
Type 1 Diabetes
Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes
This study is assessing the accuracy of continuous glucose monitors during surgical procedures requiring anesthesia.
- Trial name
- NCT06575842
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Hypertension
Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases
Obesity is a condition affecting one-third off the U.S. population and is a major risk actor for the development of Type 2 diabetes, hyperlipidemia (increased levels of fat in the blood), hypertension (high blood pressure), and…
- Conditions
- Diabetes Mellitus, Hypertension, Metabolic Disease, Obesity
- Trial name
- NCT00001723
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jack Yanovski
Type 1 Diabetes Mellitus, Type2 Diabetes Mellitus
Performance Evaluation of an Advanced Algorithm With CGM in Adults, Adolescents, and Pediatrics
The purpose of this study is to demonstrate the performance of the Guardian™ Sensor (3) with an advanced algorithm in subjects age 2 - 80 years, for the span of 170 hours (7 days).
- Trial name
- NCT03966911
- Testing
- Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter
- Where
- 15 sites in United States
- Volunteers
- 335 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
Randomized Transition to Gla-300 in Pediatric Type 1 Diabetes: CGM-Derived Outcomes
This study evaluated two different starting dose strategies when switching children and adolescents with type 1 diabetes from insulin glargine U-100 to insulin glargine U-300.
- Trial name
- NCT07872475
- Testing
- Insulin glargine U-300
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Marmara University
Diabetes, Diabetes Mellitus, Type 1
Safety and Efficacy of NovoLog vs. Humalog in Insulin Pumps in Children and Adolescents
This trial is conducted in the United States of America (USA). It is demonstrated that intensive insulin therapy resulting in good glycaemic control can reduce or delay the incidence of complications secondary to Type 1 Diabetes.
- Trial name
- NCT00097071
- Testing
- insulin lispro, insulin aspart
- Where
- 52 sites in United States
- Volunteers
- 299 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
The Impact of Different CSII and CGM Systems on Different Clinical Outcome Variables in Children and Adolescents With Type 1 Diabetes. An Observational Study Form the Norwegian Childhood Diabetes Registry (NCDR)
To examine the effect of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) on metabolic control, in a large population-based nationwide observational study under real life conditions.
- Trial name
- NCT04201171
- Testing
- CSII and CGM
- Volunteers
- 2,749 people
- Sponsor
- Helse Fonna
Obesity, PreDiabetes
ADI-PEG20, Obesity and Prediabetes
Th purpose of this study is to determine whether ADI-PEG20 (PEGylated arginine deiminase), an arginine catabolizing enzyme preparation, improves insulin sensitivity, mitochondrial respiration, and energy utilization in…
- Trial name
- NCT05829239
- Testing
- ADI-PEG20
- Where
- United States
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes
Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM
This study evaluates the efficacy of sequential transplantation of umbilical cord blood stem cells and islet cells in children with monogenic immunodeficiency type 1 diabetes mellitus.
- Trial name
- NCT03835312
- Testing
- Sequential transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Fudan University
Type 1 Diabetes, Type 2 Diabetes
ACCESS: AI for pediatriC diabetiC Eye examS Study
The purpose of this study is to determine if providing in clinic point-of-care autonomous AI diabetic retinopathy exams improves screening rates compared to standard of care referral to an eye care provider, in a randomized…
- Trial name
- ACCESS (NCT05131451)
- Testing
- Point of Care Autonomous AI diabetic retinopathy exam
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Johns Hopkins University
Type 1 Diabetes Mellitus
Real-World Evaluation of TouchCare Nano in Pediatric Type 1 Diabetes
The goal of this observational study is to learn how well the TouchCare Nano automated insulin delivery system works and how safe it is for children and adolescents with type 1 diabetes in everyday medical care.
- Trial name
- NANO-KIDS (NCT07425912)
- Where
- 3 sites in Italy
- Volunteers
- 76 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 1 Diabetes
Individualized Carbohydrate Intake Strategy to Improve Blood Glucose Control
The objective of this study is to test whether an individualized carbohydrate intake based on weight and pre physical activity glucose level is more effective than usual camp care to improve glucose control in children and…
- Trial name
- NCT03995498
- Testing
- Physical activity, FreeStyle Libre, SenseWear Armband
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Effect of Micronutrient Supplementation on Nerve Conduction Velocity in T1D- RCT
Type 1 diabetes can complicate to peripheral neuropathy due to preferential involvement of small unmyelinated nerve fibers (pain and temperature sensation) followed by myelinated nerve fibers (vibration and proprioception).
- Trial name
- NCVRCT (NCT06443593)
- Testing
- Tablet VitaBliss vitamin B12 (2.2 mcg), Tablet VitaBliss vitamin B12 (2.2 mcg) and Syrup Orofer (5 ml = 50 mg), Tablet VitaBliss vitamin B12 (2.2 mcg) and Tablet Tayo (60000 IU)
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Type 2 Diabetes
Sleep and Glycemic Control in Type 2 Diabetes Adolescents
The primary objective is to determine the cross-sectional relationship between sleep duration (as measured by 14 days of actigraphy) and glycemic control in an adolescent Type 2 Diabetes (T2DM) cohort (age 12-20y, n=67).
- Trial name
- NCT04213547
- Testing
- Loss frame sleep extension intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Philadelphia
Diabetes Mellitus, Type 1
The Impact of a Moderate Carbohydrate Diet in Children With Type 1 Diabetes on Hybrid Closed-loop Therapy
In the past, carbohydrate restriction was indicated as a treatment for people with type 1 diabetes when exogenous insulin was not available.
- Trial name
- COMBINE1 (NCT06567158)
- Testing
- Moderate carbohydrate diet, Traditional diet
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus
A New Wizard for Insulin Sensitivity Estimation From SAP: a Randomized Controlled Trial in Adolescents With T1D
We aim to test the efficacy of a new method for determining individual insulin sensitivity (IS) based on sensor-augmented-insulin pump (SAP) data in order to customize the insulin to carbohydrate ratio (CR) in adolescents with…
- Trial name
- NCT03034759
- Testing
- individualized insulin sensitivity index (ISind)
- Where
- United States
- Sponsor
- Yale University
Type 1 Diabetes (T1D), Type 1 Diabetes Mellitus
Twiist Postmarket Surveillance Study for Type 1 Diabetes
The goal of this surveillance study is to collect real-world data on adults and youth with type 1 diabetes (T1D) using twiist(TM) for insulin delivery.
- Trial name
- twiist-PS (NCT07356089)
- Testing
- twiist Automated Insulin Delivery System
- Where
- United States
- Volunteers
- 1,875 people
- Sponsor
- Deka Research and Development