Clinical trials: Diabetes in Adolescence
Type 1 Diabetes
"MyPlan" - Individualized Planned Eating Patterns for Adolescents With Type 1 Diabetes
The purpose of this study is to test the acceptability and effectiveness of an individualized eating strategy as part of diabetes self-management to improve glycemic levels among youth with type 1 diabetes (T1D) and suboptimal…
- Trial name
- NCT05147324
- Testing
- "MyPlan" - Individualized Planned Eating Pattern
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of North Carolina, Chapel Hill
Type1diabetes, Sleep
Sleep Patterns and Chronotype in Children With and Without Type 1 Diabetes
Type 1 diabetes (T1D) is one of the most common chronic childhood diseases. Recent studies have highlighted the strong association between type 1 diabetes and sleep health problems.
- Conditions
- Type1diabetes, Sleep, Chronotype
- Trial name
- NCT06318611
- Testing
- sleep, chronotype
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Koç University
Type 2 Diabetes
Arginine Metabolism in Youth With Type 2 Diabetes
Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology…
- Trial name
- NCT05477134
- Testing
- Stable isotope infusion, oral glucose ingestion, intravenous arginine bolus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 1, Hyperglycemia, Postprandial
Effect of Protein Intake on Post Prandial Hyperglycemia in Children and Adolescents With Type1 Diabetes Mellitus
In type 1 Diabetes Mellitus, patients receive insulin doses if they consume specific amounts of carbohydrates. Currently, insulin is not being administered for consumption of protein although studies in adults show that consuming…
- Trial name
- NCT04655131
- Testing
- Whey protein isolate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Type 1 Diabetes Mellitus
PRISM for Adolescents With Type 1 Diabetes
It is well-known that adolescents with type 1 diabetes are at high risk for elevated diabetes-specific distress and poor glycemic control.
- Trial name
- NCT03847194
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Seattle Children's Hospital
Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus
Glucose Intolerance and Diabetes Related to Treatment With Steroids and PEG- Asparaginase in Children and Adolescents With ALL and Lymphoma
The overall survival of acute lymphoblastic leukemia (ALL) and lymphoma in children and adolescents is above 90%. The survival rate has increased significantly during the last decades as a consequence of more intensive…
- Conditions
- Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus, Impaired Glucose Tolerance, Lymphoma
- Trial name
- NCT05873322
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Type 1 Diabetes Mellitus
Hypoglycemia Prevention After Exercise in Adolescent T1DM Patients Using a Control to Range System
In this protocol the investigators plan to demonstrate management of glucose using a modular insulin management system based on continuous glucose monitoring and targeted towards the avoidance of hypoglycemic and prolonged…
- Trial name
- MDB005 (NCT01390259)
- Testing
- Open-Loop, Closed-Loop
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Virginia
Prediabetic State, Insulin Resistance
United for Health: Type 2 Diabetes Prevention in Latino Teens
This study pilots the feasibility and acceptability of a family-based lifestyle intervention for decreasing diabetes risk called "Salud sin Barreras" (meaning, "Health without Barriers") delivered in the community to Latino teens…
- Conditions
- Prediabetic State, Insulin Resistance, Type2 Diabetes, Stress
- Trial name
- UNITED (NCT03527641)
- Testing
- CookingMatters, Parent Education, Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Colorado State University
Type 1 Diabetes
Use of Terbutaline or a Reduction in Basal Insulin in the Prevention of Nocturnal Hypoglycemia
The investigators hypothesize that the use of an oral dose of Terbutaline or a 20% basal reduction will be able to prevent nocturnal hypoglycemia after an afternoon exercise session.
- Trial name
- NCT00974051
- Testing
- Terbutaline, 20% basal insulin reduction, Control
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Mental Health Issue, Diabetes Distress
Examining the Feasibility of Wysa in Hindi
The principal objective of this study is to investigate the feasibility of including a digital mental health intervention (Wysa in Hindi) within pre-existing usual care to support adolescents and young adults with Type 1 Diabetes…
- Trial name
- NCT06320756
- Testing
- Wysa in Hindi, Individual and group sessions on topics like motivation, coping, wellbeing
- Where
- India
- Volunteers
- 79 people
- Sponsor
- Wysa
Cardiovascular Diseases, Type2diabetes
Physical Activity and CVD in Adolescents With Type 2 Diabetes
The main research questions for this study are: (1) Is delivering a resiliency-informed behavioural intervention designed to increase physical activity (PA) feasible for adolescents living with Type 2 Diabetes (T2D)? and (2) What…
- Trial name
- CVD (NCT05724888)
- Testing
- Peer mentorship and physical activity
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type2 Diabetes, Type 2 Diabetes Mellitus
Depression & Insulin Sensitivity in Adolescents
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance
- Trial name
- NCT03263351
- Testing
- Cognitive-behavioral therapy group, Health education group
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Colorado State University
Impaired Glucose Tolerance, Prediabetes
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical.
- Trial name
- NCT05387551
- Testing
- CGM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
Transfusion Dependent Beta Thalassemia
Glucagon-Like Peptide 1 Receptor Agonist in Diabetes Mellitus Management in Children and Adolescents With Transfusion-Dependent Thalassemia
Blood transfusion and iron-chelation therapy have prolonged and improved the quality of life in patients with β-thalassemia. The improvement was mainly due to the decrease in mortality from heart failure Such a treatment…
- Trial name
- NCT07370922
- Testing
- Dulaglutide 0.75Mg/0.5Ml Inj Pen, control group (insulin)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Type1 Diabetes, Adolescents
Real-world Use of Hybrid Closed Loop in Adolescents and Young Adults 15-25 Years of Age with Type 1 Diabetes
The purpose of this study is to determine the effect of hybrid closed loop on glycemic outcomes in young patients aged between 15 and 25 years old with type 1 diabetes, whatever is their initial metabolic control.
- Conditions
- Type1 Diabetes, Adolescents, Young Adults
- Trial name
- BFHado (NCT06253351)
- Testing
- Hybrid closed loop (HCL)
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 2 Diabetes, Depression
Mindfulness-Based Intervention for Depression and Insulin Resistance in Adolescents
Rates of type 2 diabetes (T2D) in adolescents have escalated. Adolescent-onset is associated with greater health comorbidities and shorter life expectancy than adult-onset T2D.
- Conditions
- Type 2 Diabetes, Depression, Insulin Resistance, Obesity
- Trial name
- NCT04992299
- Testing
- Mindfulness-Based Intervention, Cognitive-Behavioral Therapy, Health Education
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Type 1 Diabetes Mellitus (T1DM)
Prospective Cohort Study of Children Diagnosed with Type 1 Diabetes in Türkiye Between 2018 to 2022
Achieving glycemic targets with improved T1DM management reduces diabetes complications and the risk of progression. Thus, it is essential to identify the challenges in T1DM management within the country and develop strategies…
- Trial name
- NCT06892821
- Where
- Turkey (Türkiye)
- Volunteers
- 2,730 people
- Sponsor
- Turkish Pediatric Diabetes Working Group
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Diabetes Mellitus, Type 1
ECG Changes in Children and Adolescents With Type 1 Diabetes
Diabetes Mellitus type 1 is characterized by an absolute insulin deficiency caused by T-cell-mediated autoimmune destruction of pancreatic β-cells .
- Trial name
- NCT03260998
- Testing
- electrocardiogram
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes Mellitus
Insulin-based Strategies to Prevent Hypoglycemia During Two Types of Exercise
Regular exercise is associated with many health benefits for individuals with type 1 diabetes. However, immediate and delayed exercise-induced hypoglycemia is frequent and thus the main limiting factor for physical activity…
- Trial name
- RIDE-2 (NCT03845114)
- Testing
- Continous exercise, Interval exercise, Reduction of basal insulin by 40%
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal