Clinical trials: Diabetes in Adolescence
Type 1 Diabetes
Hybrid Closed-Loop Control With Smart Prandial Insulin Dosing in Type 1 Diabetes
The objective of this study is to evaluate the safety and feasibility of a smart bolus calculator that adjusts insulin dosing for meals according to real-time insulin sensitivity (SI) in adolescents with type 1 diabetes (T1D)…
- Trial name
- NCT04878120
- Testing
- Standard HCL System, HCL System with Smart Bolus Calculator
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Diabetes
Use of MiniMed 780G System in Children and Adolescents
Hybrid closed-loop technology have shown that it improves glycemic control parameters, but the investigators do not have sufficient data at more than 6 months of follow-up, allowing us to describe the effectiveness of these…
- Trial name
- NCT05591690
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Montpellier
Adolescent Behavior
Family Consumer Behaviors, Adolescent Prediabetes and Diabetes
The aim of this study was to examine the association between family consumer behaviors (healthy food availability and supermarket spending) and adolescent prediabetes and diabetes.
- Trial name
- NCT03136289
- Testing
- Family Consumer Behaviors
- Volunteers
- 2,520 people
- Sponsor
- Rutgers University
Obesity, Prediabetes
Effect of Aerobic Exercise Program on Blood Glucose Level and Quality of Life in Pre-diabetic Overweight/Obese Adolescents
PURPOSE: The study aims to: Investigate the effect of the designed aerobic exercise program on the blood glucose level (fasting blood glucose and HbA1C) in overweight/ obese pre-diabetic adolescents.
- Trial name
- NCT06756425
- Testing
- aerobic exercise program, nutritional health awareness sessions
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Type 1 Diabetes Mellitus
Improving Self-Efficacy, Quality of Life and Glycemic Control in Adolescents With Type 1 Diabetes
Empowerment in healthcare, particularly in the context of chronic illness management such as diabetes, entails equipping patients with knowledge, expertise, and self-assurance to proactively oversee their health and make…
- Trial name
- NCT06694467
- Testing
- Education program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Near East University, Turkey
Diabetes Mellitus, Type 1 Diabetes Mellitus
Effects of a Remote Patient Monitoring Protocol on Glycemic Control in Adolescents With Type 1 Diabetes
This study will use a randomized, crossover design. Children aged 13-18 years who have been diagnosed with Type 1 diabetes for at least 1 year and with at least 2 Hemoglobin A1c values ≥10.0% more than 60 days apart within the…
- Trial name
- NCT03466398
- Testing
- Vivify Health RPM Protocol
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents
This study evaluates the impact of the hybrid closed-loop insulin delivery systems on sleep in youth with type 1 diabetes and their parents.
- Trial name
- NCT04431947
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Parent Mentors to Improve Adherence to Type I Diabetes Care Regimen in Adolescents
The study aim is to determine if parent mentors can improve adherence to the intensive multiple daily injection regimen (MDI) or the insulin pump therapy, through monitoring the frequency of blood glucose measurements.
- Trial name
- NCT03199716
- Testing
- Parent mentors
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Davis
Type 1 Diabetes (T1D)
Effects of Bedtime Snack Composition on Overnight Glucose in Children and Adolescents With Type 1 Diabetes
This study compared four types of bedtime snacks in children and adolescents with type 1 diabetes treated with multiple daily insulin injections.
- Trial name
- NCT07778147
- Testing
- Carbohydrate-Only Bedtime Snack, Carbohydrate-Plus-Protein Bedtime Snack, Carbohydrate-Plus-Fat Bedtime Snack
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Didem Güneş Kaya
Type 1 Diabetes Mellitus
Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes
The treatment regimen for type 1 diabetes is complex and demanding, and many adolescents experience diabetes distress related to the daily demands of diabetes care, which can cause problems with diabetes management and glycemic…
- Trial name
- T1D (NCT03845465)
- Testing
- Positive Affect + Education, Education
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Technology-delivered Physical Activity Program for Adolescents With Type 1 Diabetes
This project is comprised of a two-arm randomized control trial (RCT) testing the feasibility, acceptability, and preliminary efficacy of a nationally scalable program, Activate, a 12-week, technology-delivered diabetes…
- Trial name
- Activate (NCT05319600)
- Testing
- Diabetes behavior change skills training, Physical activity promotion program
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
PreDiabetes, Overweight
Night Owl Metabolism
The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test…
- Conditions
- PreDiabetes, Overweight, Impaired Glucose Tolerance
- Trial name
- NCT06507722
- Testing
- Timing of OGTT, Timing of Standardized Meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Self-regulation, Medication Adherence
Adolescent Interventions to Manage Self-regulation of T1D (AIMS T1D)
This goal of this project is to test whether self-regulation assays and interventions can be delivered and change self-regulation in a sample of adolescents, specifically to test in a small randomized clinical trial (RCT) whether…
- Trial name
- NCT03688919
- Testing
- Self-Regulation Intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2
Adolescent-mediated Family Diabetes Intervention: American Samoa
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of an adolescent-mediated intervention designed to improve the glycemic control and self-care practices of a parent/grandparent.
- Trial name
- NCT05356884
- Testing
- Diabetes Intervention, Leadership & Life Skills
- Where
- American Samoa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
Assessment of an iPhone Application on Glycemic Control in Type 1 Diabetes
The purpose of the study is to assess whether an electronic self-management tool, specifically an iPhone application entitled bant, can improve glycemic control in Adolescents who have Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT01899274
- Testing
- bant iPhone application
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus
Social Determinants of Global Pediatric Diabetes
There is little data from low-income countries on setting and culture specific perception of childhood diabetes and disease specific stressors including stigma, and how these may affect disease related quality of life, coping…
- Trial name
- DESIDE (NCT04272099)
- Testing
- Administration of standardized questionnaires, Physical activity tracker, Dietary log
- Where
- 4 sites in Canada, Haiti
- Volunteers
- 79 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Type 1, Nephropathy
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
Over 1.25 million Americans have type 1 diabetes (T1D), increasing risk for early death from cardiorenal disease. The strongest risk factor for cardiovascular disease (CVD) and mortality in T1D is diabetic kidney disease (DKD).
- Conditions
- Diabetes Mellitus, Type 1, Nephropathy, Diabetic Nephropathies, Juvenile Diabetes
- Trial name
- CASPER (NCT03618420)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Hypoglycemia, Diabetes Mellitus
Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents
Up to fifty (50) children and adolescents with type 1 diabetes (T1D) aged 4 to ˂18 years at time of enrolment will be selected for inclusion in the study.
- Trial name
- NCT02402933
- Testing
- Nasal Glucagon
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1, Diabetes
Insulin Deprivation on Brain Structure and Function in Humans With Type 1 Diabetes
What are the effects of transient insulin deprivation on brain structure, blood flow, mitochondrial function, and cognitive function in T1DM patients? What are the effects of transient insulin deprivation on circulating exosomes…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes, Diabetes Complications
- Trial name
- NCT03392441
- Testing
- Insulin Deprivation in Type 1 Diabetic Patients
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 1
Comparison of Real-tiMe ContInuous gLucosE moNitoriNg With Self-monitorIng of Blood Glucose in Young AduLts With Type 1 diabeteS
The main objective of this study is to determine whether real-time continuous glucose monitoring (CGM) for 8 weeks is more efficacious compared to self-monitoring of blood glucose (SMBG) in young adults with type 1 diabetes.
- Trial name
- MILLENNIALS (NCT03445377)
- Testing
- Real-time continuous glucose monitoring, Self-monitoring of blood glucose
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Manchester University NHS Foundation Trust