Clinical trials: Diabetes-Related Complications
Diabetic Retinopathy
Evaluation System and Clinical Application for Diabetic Retinopathy
Diabetic retinopathy(DR) is one of the most common and serious microvascular complications of diabetes,which is the primary cause of vision loss of diabetic patients.
- Trial name
- NCT03528720
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Pain, Diabetic Neuropathy
A Study of Sativex® for Pain Relief Due to Diabetic Neuropathy
The purpose of this study is to evaluate the efficacy of Sativex® compared with placebo in relieving pain due to Diabetic Neuropathy.
- Trial name
- NCT00710424
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 297 people
- Sponsor
- Jazz Pharmaceuticals
Diabetic Foot, Venous Ulcer
Adipose Derived Regenerative Cellular Therapy of Chronic Wounds
Our study aims to explore the effects of Adipose Derived Stem Cells (ASCs) on chronic wounds.
- Conditions
- Diabetic Foot, Venous Ulcer, Pressure Ulcer
- Trial name
- NCT02092870
- Testing
- Adipose derived stem cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Tower Outpatient Surgical Center
Diabetes Mellitus, Type 2
Effect of Nutrition Education Groups in the Treatment of Patients with Type 2 Diabetes
Every year there is an increase in people with diabetes all over the world. Because it is a disease associated with several comorbidities and is increasing, there is a need for more effective treatments.
- Trial name
- NCT05598203
- Testing
- Operative group of nutrition education
- Where
- 2 sites in Brazil
- Volunteers
- 252 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetic Neuropathies, Chronic Pain
Perineural Platelet-rich Plasma for Diabetic Neuropathy Pain
Peripheral neuropathy is very common in diabetes mellitus (DM). Till now there is no available effective therapy for this pathology.
- Trial name
- NCT03601494
- Testing
- perineural injection of platelet-rich plasma, medical
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Diabetic Nephropathy
6-Month Safety And Efficacy Study Of TTP488 In Patients With Type 2 Diabetes And Persistent Albuminuria
Current research indicates that TTP488 may be a viable agent for the treatment of diabetic nephropathy. The purpose of this study is to determine the safety and efficacy of a six-month regimen of daily orally-administered TTP488…
- Trial name
- NCT00287183
- Testing
- PF-04494700 (TTP488)
- Where
- 19 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Pfizer
Diabetic Neuropathies
Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy
One of the most common complications of diabetes mellitus is diabetic polyneuropathy, which leads to disability and reduces quality of life.
- Trial name
- CYLINDER (NCT04649203)
- Testing
- Cytoflavin (Inosine + Nicotinamide + Riboflavin + Succinic Acid)
- Where
- 16 sites in Russia
- Volunteers
- 216 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Painful Diabetic Neuropathy, Diabetic Neuropathy, Painful
Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy
The purpose of this study is to explore the overall safety profile and durability of efficacy of Engensis (VM202) in painful diabetic peripheral neuropathy.
- Trial name
- NCT04055090
- Testing
- Long-Term Follow-Up of Patients who Received Engensis (VM202)
- Where
- 14 sites in United States
- Volunteers
- 101 people
- Sponsor
- Helixmith Co., Ltd.
Diabetic Foot Ulcers
Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers
The primary objective of the present study is to further establish in a randomized controlled trial, the safety and efficacy of weekly Grafix® administration versus control in patients with chronic diabetic foot ulcers.
- Trial name
- DFU (NCT01596920)
- Testing
- Tissue, Control
- Where
- 15 sites in United States
- Volunteers
- 97 people
- Sponsor
- Osiris Therapeutics
End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria
Clinical Observation of Renal Function Reactivation Following a GRAS-Based Protocol in Patients With Chronic Kidney Disease and Long-Term Renal Arrest.
This observational study documents the impact of a specific oral protocol (based on FDA-GRAS ingredients) on patients with Stage 5 Chronic Kidney Disease (CKD).
- Conditions
- End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria, End-Stage Renal Disease (ESRD), Chronic Kidney Disease, Stage 5
- Trial name
- NCT07555327
- Testing
- CSR-CKD Oral Protocol
- Where
- Algeria
- Volunteers
- 8 people
- Sponsor
- Amar h Zireg
Neonatal Hypoglycemia, Infant, Small for Gestational Age
Effect of Tahneek on Hypoglycemia in Newborn Infants
Tahneek is an Arabic word which means putting something sweet such as dates, in the infant's mouth after the birth. Neonatal hypoglycemia is common in the first few days after birth.
- Conditions
- Neonatal Hypoglycemia, Infant, Small for Gestational Age, Macrosomia, Fetal, Intrauterine Growth Restriction
- Trial name
- THIN (NCT03726697)
- Testing
- Tahneek
- Where
- Saudi Arabia
- Volunteers
- 324 people
- Sponsor
- King Abdullah International Medical Research Center
Diabetic Foot Ulcer (DFU)
HPTC Versus AFSM in Diabetic Foot Ulcers
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers at multiple centres in India and Bangladesh.
- Trial name
- NCT07781917
- Testing
- High Purity Type-I Collagen-Based Skin Substitute and SOC, Acellular Intact Fish Skin Matrix and SOC
- Where
- 4 sites in Bangladesh, India
- Volunteers
- 120 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Diabetic Foot Ulcer (DFU), Uncontrolled Diabetes With Foot Ulcer
Effect of WF10 (TCDO) on HbA1c Values in Diabetic Foot Ulcer Patients
Study in adult Diabetes Mellitus patients with diabetic foot ulcers and elevated HbA1c who will receive standard wound treatment in combination with adjuvant therapy WF10 to compare the change of HbA1c levels at baseline and…
- Trial name
- NCT04372355
- Testing
- WF10
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Srinakharinwirot University
Type2 Diabetes
Renal Actions of Combined Empagliflozin and LINagliptin in Type 2 diabetES
The current study aims to explore the clinical effects and mechanistics of mono- and combination therapy with SGLT-2 inhibitor empagliflozin and DPP-4 inhibitor linagliptin on renal physiology and biomarkers in metformin-treated…
- Trial name
- RACELINES (NCT03433248)
- Testing
- EMPA/LINA 10/5 mg QD (n=22), LINA/EMPA 5/10 mg QD (N=22), Gliclazide 30 mg QD/BID (N=22)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- M.H.H. Kramer
Wounds, Diabetes Complications
Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics
The purpose of this study is to determine whether using the OWEMR as part of the standard of care for Diabetic Foot Ulcers reduces the rate of lower limb amputations and to quantify the relationship between glycemic control and…
- Conditions
- Wounds, Diabetes Complications, Diabetic Foot, Foot Ulcer
- Trial name
- OWEMR (NCT01371318)
- Testing
- Online Wound Electronic Medical Record
- Where
- 13 sites in United States
- Volunteers
- 1,609 people
- Sponsor
- NYU Langone Health
Diabetic Ketoacidosis
Subcutaneous Aspart Insulin to Treat Diabetic Ketoacidosis (DKA) and Beta-Hydroxybutyrate Testing in DKA
The purpose of this study is to determine whether insulin administered by a subcutaneous injection is effective in the treatment of a diabetic crisis and to determine if beta-hydroxybutyrate is useful to monitor during treatment…
- Trial name
- DKA (NCT00920725)
- Testing
- Insulin (Aspart Insulin [Novolog], Regular Insulin)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Age Related Macular Degeneration, Diabetic Retinopathy
Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab
The purpose of this study is to evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure variations after intravitreal bevacizumab injection.
- Trial name
- NCT00864838
- Testing
- Acetazolamide, Brimonidine tartarate, Anterior chamber paracentesis
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Fetal Macrosomia, Congenital Abnormality
Fish Oil Supplementation in Women With Gestational Diabetes
Gestational diabetes is the development of diabetes during pregnancy. Left untreated, gestational diabetes and preeclampsia can lead to serious -- or even fatal -- complications for both mother and child.
- Conditions
- Fetal Macrosomia, Congenital Abnormality, Other Respiratory Problems After Birth
- Trial name
- NCT02371343
- Testing
- Fish oil, Ocean plus, Sunflower Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Diabetic Foot Ulcer, Non-healing Diabetic Foot Ulcer
EPC Silver Wound Gel (EPC-123) Feasibility Study in the Management of Mildly Infected Diabetic Foot Ulcers
The objective of this single-arm feasibility study is to investigate the safety and impact of the topical EPC Silver Wound Gel (EPC-123) in the management of diabetic foot ulcer wounds not progressing under the current standard…
- Conditions
- Diabetic Foot Ulcer, Non-healing Diabetic Foot Ulcer, Diabetic Foot Infection
- Trial name
- NCT05243810
- Testing
- EPC Silver Wound Gel
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Exciton Technologies Inc.
Diabetic Retinopathy
A Study of PER-001 in Participants With Diabetic Retinopathy
This is a Phase 2a, randomized, single-masked (participant), sham controlled clinical study.
- Trial name
- NCT06003751
- Testing
- PER-001 Intravitreal Implant - Low Dose, PER-001 Intravitreal Implant - High Dose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Perfuse Therapeutics, Inc.
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