Clinical trials: Diabetes-Related Complications
Type 2 Diabetes, Diabetic Kidney Disease
Renal Mechanism of SGLT2 Inhibition
Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA).
- Trial name
- NCT05507892
- Testing
- canagliflozin, Aminohippurate Sodium Inj 20%
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
Diabetes and Risk of Diabetic Foot Ulcer
Pressure and Diabetic Foot
Diabetic foot ulcer (DFU) is a worldwide burden in the management of patients with diabetes. Peripheral neuropathy has a key role in the physiopathology of DFU.
- Trial name
- PIV & MPP (NCT03213093)
- Testing
- Measure of cutaneous microcirculation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus, Type 2, Diabetic Nephropathy
Molecular and Clinical Profile of Diabetes Mellitus and Its Complications
Background: Family and twin studies have suggested that genetic factors influence approximately 50 percent of a person's susceptibility to type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Nephropathy, Obesity
- Trial name
- NCT01105858
- Where
- United States
- Volunteers
- 2,310 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Atherosclerosis, Complications of Diabetes Mellitus
18F-Sodium Fluoride (18F-NaF) PET-CT Imaging to Identify Vulnerable Plaques in Patients With Diabetes
Coronary artery calcification is a sign of heart disease. A nuclear medicine PET-CT test using sodium fluoride (18F-NaF) radioisotope has been shown to help identify growing calcification plaques early on in the disease process.
- Trial name
- D-NaF (NCT03530176)
- Testing
- 18Fluoride-Sodium Fluoride radio-isotope
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes, Diabetic Foot
C-myc Biomarker Study for Diabetic Foot Ulcers
This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing.
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
- Trial name
- NCT04591691
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Diabetic Neuropathies
Effects of Aerobic Training and Neurodynamics to Prevent Fall and Improve Balance in Patients With Diabetic Neuropathy
Diabetes is a group of metabolic diseases, characterized by hyperglycemia resulting from defects in insulin secretion, actionor both.
- Trial name
- NCT06240910
- Testing
- Neurodynamics, Aerobic training
- Where
- 2 sites in Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Diabetic Foot Ulcer (DFU)
AI Wound Alert & Home Management for Recurrent DFU
Diabetes is one of the major chronic diseases, and diabetic foot ulcer (DFU) is a significant adverse prognosis of diabetes. The recurrence of DFU after healing involves multiple risk factors, such as changes in foot loading…
- Trial name
- NCT07277010
- Testing
- Individualized follow-up care
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Skin Ulcer
Bio-ConneKt Wound Dressing for Treatment of Chronic Leg Wounds: A Pilot Study
The purpose of this study is to assess the performance of the bio-ConneKt™ wound dressing and compare its performance with the standard of care at NFRMC Wound Therapy Services, for the treatment of chronic foot/leg ulcers…
- Trial name
- NCT02309684
- Volunteers
- 20 people
- Sponsor
- MLM Biologics Inc.,
Diabetic Retinopathy
Fenofibrate for Prevention of DR Worsening
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR…
- Trial name
- Protocol AF (NCT04661358)
- Testing
- Fenofibrate
- Where
- 66 sites in United States
- Volunteers
- 563 people
- Sponsor
- Jaeb Center for Health Research
Peripheral Arterial Disease, Diabetic Foot Ulcer
Study of PDA-002 in Subjects With Peripheral Arterial Disease and Diabetic Foot Ulcers
This Phase 1, multicenter, open-label, dose-escalation study evaluated the safety and tolerability of intramuscular administration of PDA-002 (human placenta-derived cells) in subjects with peripheral arterial disease (PAD) and…
- Trial name
- NCT01859117
- Testing
- PDA-002
- Where
- 12 sites in United States
- Volunteers
- 15 people
- Sponsor
- Celularity Incorporated
Diabetic Kidney Disease, IgA Nephropathy
A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease
This is a phase II study to investigate the safety, preliminary efficacy and pharmacokinetics of SC0062 capsule in patients with chronic kidney disease (diabetic kidney disease and IgA nephropathy)with albuminuria compared to…
- Trial name
- NCT05687890
- Testing
- SC0062 low dose, SC0062 medium dose, SC0062 high dose
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Biocity Biopharmaceutics Co., Ltd.
Diabetic Foot
Removable Walker for Neuropathic Ulcers
1. Objective: To evaluate the efficacy of removable cast walker compared to non-removable fiberglass off-bearing cast in the treatment of diabetic plantar foot ulcer 2.
- Trial name
- NCT01005264
- Testing
- non-removable fiberglass, Stabil-D®
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS Multimedica
Diabetic Neuropathies, Diabetes Mellitus
The Effect of Sensorial Biodex Balance Balance System Exercises in Diabetic Neuropathy
This study examined the effects of balance exercises performed with the Biodex Balance System (BBS) on nerve conduction, sensory symptoms, and muscle strength in patients with diabetes-related neuropathy.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Exercise Training
- Trial name
- NCT05255497
- Testing
- Biodex Balance Exercise System
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duygu AKTAR REYHANIOGLU
Diabetic Retinopathy
Analysis of DR Progression to Identify Risks and Need for Treatment
The goal of this observational study is to understand whether vascular and structural changes in the eyes caused by diabetes can help predict which people are more likely to experience worsening diabetic retinopathy (a…
- Trial name
- ALERT (NCT07417410)
- Where
- Portugal
- Volunteers
- 1,000 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Neuropathy
Effects of Pulsatile Intravenous Insulin Delivery on Diabetic Neuropathy in pATIENTS (Pts) With Type 1 and Type 2 Diabetes
Diabetic neuropathy is a progressive complication causing serious problems in 25-40% of diabetic patients. Anecdotal reports have indicated improvement with pulsatile IV insulin therapy in affected patients otherwise resistant to…
- Trial name
- NCT00228904
- Testing
- Pulsatile IV insulin delivery (humalog, humulin, novolog)
- Where
- United States
- Sponsor
- Florida Atlantic University
Diabetic Kidney Disease
Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine
Background: Diabetic kidney disease (DKD) is chronic and often progresses to kidney failure,heart disease and premature death. Unfortunately, the best medical therapies available for DKD today are ultimately unable to prevent its…
- Trial name
- PROMISE (NCT02011178)
- Testing
- Optimal medical treatment and surgery, Optimal medical treatment
- Where
- 2 sites in Sweden, Switzerland
- Sponsor
- Karolinska Institutet
Diabetic Foot Ulcer, Diabetes
Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic…
- Trial name
- NCT02328508
- Testing
- Hyperbaric oxygen therapy
- Volunteers
- 38 people
- Sponsor
- Chen-Yu Chen
Diabetic Polyneuropathy, Weight Loss
Evaluating the Effect of Diabetes Control Through Intensive Lifestyle Modifications on Diabetic Peripheral Neuropathy
The purpose of this study is to find out the impact of improving diabetes control through weight reduction and lifestyle changes on a common diabetes complication called peripheral neuropathy.
- Trial name
- NCT01565317
- Testing
- Weight Achievement and Intensive Treatment (Why WAIT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Joslin Diabetes Center
Diabetic Retinopathy, Diabetic Macular Edema
Aqueous Biomarker Levels in Diabetic Retinopathy and Diabetic Macular Edema
The DRAGONS study is a non-interventional, prospective study that will 1. characterize disease state biomarker (including cytokines, KKS metabolites, and cell adhesion molecules) levels from aqueous humor of subjects with various…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Other Retinal Disorders
- Trial name
- DRAGONS (NCT05333055)
- Where
- 3 sites in United States
- Volunteers
- 107 people
- Sponsor
- Greater Houston Retina Research
Hammer Toe Syndrome, Foot Ulcer, Diabetic
Flexor Tenotomy and Ulcer Recurrence
The main purpose of this study is to assess the efficacy of flexor tenotomy on the prevention of recurrence of toe ulcers in people with diabetes and a history of toe ulceration.
- Trial name
- NCT05228340
- Testing
- Flexor tenotomy
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
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