Clinical trials: Diabetes-Related Complications
Diabetes Complications
Dose Response of Epinephrine
Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial function and atherothrombotic balance in…
- Trial name
- Epineprhine (NCT02692313)
- Testing
- Epinephrine, Saline infusion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Ketosis Prone Diabetes, Diabetic Ketoacidosis
Ketosis Prone Diabetes in African-Americans
Over 50% of obese African-Americans (AA) presenting with newly diagnosed, severe hyperglycemia and/or unprovoked diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of type 2 diabetes.
- Conditions
- Ketosis Prone Diabetes, Diabetic Ketoacidosis, Severe Hyperglycemia
- Trial name
- NCT00426413
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetic Foot Ulcer
Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers
Diabetic foot ulcers (DFU) develop because of the interaction of predisposing factors like neuropathy, angiopathy and infection. Likewise, environmental factors like lesion hygiene, diet and life style.
- Trial name
- NCT02632877
- Testing
- Pirfenidone with MODD, Ketanserin
- Where
- 2 sites in Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Diabetic Foot Ulcer
Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot Ulcers
The purpose of this study is to determine the safety and efficacy of Dermal-LSR plus Standard of Care (SOC) for the treatment of diabetic foot ulcers (DFU)in comparison to the treatment to SOC alone.
- Trial name
- NCT00387101
- Testing
- Dermal - Living Skin Replacement (Dermal - LSR)
- Where
- 12 sites in United States
- Volunteers
- 288 people
- Sponsor
- ApoPharma
Diabetic Foot Ulcers
Phase 3 Study Evaluating Efficacy and Safety of DSC127 Compared With Vehicle and With Standard-of-care in Diabetic Foot Ulcers
To determine if aclerastide (DSC127) is effective in increasing incidence of complete wound closure up to 10 weeks confirmed 2 weeks later, compared with vehicle (gel without active ingredient) and compared with a…
- Trial name
- STRIDE 2 (NCT01849965)
- Testing
- DSC127, Standard of Care gel, Aquasite
- Where
- 56 sites in United States, Canada and 2 more
- Volunteers
- 396 people
- Sponsor
- Integra LifeSciences Corporation
Type 1 Diabetes
Effect of Automated Insulin Delivery on Early-stage Diabetic Complications
Aim of this study is to verify the effects of an advanced HCL (Medtronic Minimed™ 780G) compared to SAP with PLGS on metabolic outcomes and markers of early microvascular damage in a population of adults with T1D previously…
- Trial name
- AID-Comp (NCT05477030)
- Testing
- Medtronic MiniMed 780G with SmartGuard activation, Medtronic MiniMed 780G without SmartGuard activation
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Milan
Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU)
The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.
Primary outcome: To evaluate the efficacy of L-Carnitine supplementation on length and depth ulcer size Secondary outcome: To investigate the effect of L-Carnitine supplements on: 1. Vascular endothelial growth factor (VEGF) 2.
- Trial name
- NCT07768228
- Testing
- L- carnitine
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Diabetic Kidney Disease
IvaBradinE to Treat MicroalbumiNuria in Patients With Type 2 Diabetes and Coronary Heart Disease
To explore the efficacy of Ivabradine for the treatment of microalbuminuria in patients with type 2 diabetes and coronary heart disease.
- Trial name
- BENCH (NCT03105219)
- Testing
- Ivabradine
- Where
- China
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Diabetic Foot, Orthopedic Disorder
Clinical Efficacy of a 3D Foot Scanner for the Therapeutic Footwear Fitting
Patients with diabetes at high risk of ulceration require a perfect fitting shoe to avoid high shear and pressure forces. Neuropathy skews sensory perceptions and can alter the proper selection of the therapeutic footwear.
- Conditions
- Diabetic Foot, Orthopedic Disorder, Foot Ankle Injuries
- Trial name
- Smartfitting (NCT05353114)
- Testing
- 3D feet scan (smart-fitting by Podiapp - Podartis s.r.l Unipersonale-Crocceta del Montello (TV), Italy).
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes, Diabetic Nephropathy
Effects of SGLT2 Inhibition Treatment on Different Levels of Albuminuria in Patients With Type 2 Diabetes
Diabetic kidney disease has become the leading cause for ESRD worldwide.Albuminuria is a major risk factor for progression of diabetic nephropathy.
- Trial name
- NCT04127084
- Testing
- SGLT2 Inhibition
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongshan Hospital Xiamen University
Diabetic Peripheral Neuropathy
Strength And Balance Training on Diabetic Peripheral Neuropathy
A Randomized Control Trial was conducted on 20 participants, equally allocated in strength plus balance and aerobic group from February-2020 until December-2020.Participants were selected according to inclusion and exclusion…
- Trial name
- NCT04807452
- Testing
- Strength and balance training, Aerobics training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Type 1 Diabetes, Diabetic Retinopathy
The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes
The purpose of this study is to compare the effect of two antihypertensive drugs on retinal vessel diameter in young type 1 diabetics.
- Conditions
- Type 1 Diabetes, Diabetic Retinopathy, Eye Diseases, Diabetes Complications
- Trial name
- NCT00337298
- Testing
- Amlodipine, Lisinopril
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, High Blood Pressure
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
The objective of this study is to compare the effectiveness of a novel program-Family Support for Health Action (FAM-ACT) - to individual patient-focused diabetes self-management education and support (I-DSMES).
- Conditions
- Diabetes Mellitus, High Blood Pressure, High Blood Sugar, Hypertension
- Trial name
- NCT03812614
- Testing
- FAM ACT, I-DSMES
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Pittsburgh
Diabetic Neuropathy, Balance
Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Neuropathy
Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, characterized by impaired sensory and motor function, often leading to balance dysfunction and an increased risk of falls.
- Conditions
- Diabetic Neuropathy, Balance, Cognitive Dysfunction, Cognitive Decline
- Trial name
- NCT07394504
- Testing
- Turning Based Dual Task Training, Dual-Task Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation University Islamabad
Diabetes Mellitus, Depression
Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness
Psychological Impact, Metabolic Control, and Biological Stress Markers in Diabetes: Intervention Study With Affect School and Basal Body Awareness Background: Depression is common in patients with diabetes and is associated with…
- Conditions
- Diabetes Mellitus, Depression, Alexithymia, Anxiety
- Trial name
- NCT01498614
- Testing
- Affect School and Basal body awareness
- Where
- Sweden
- Volunteers
- 321 people
- Sponsor
- Lund University
Arterial Insufficiency
Evaluation of a Paraclinical Test for the Diagnosis of Arterial Insufficiency in Diabetic Patients With Foot Ulcers
The number of people living with diabetes has quadrupled worldwide since 1990, and more than 4.5 million people in France have diabetes.
- Trial name
- INFLUX-D (NCT07732270)
- Testing
- Handheld Doppler
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Diabetic Macular Edema
A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept in participants with treatment-naïve DME.
- Trial name
- GLIMMER (NCT04603937)
- Testing
- KSI-301, Aflibercept
- Where
- 72 sites in United States, Czechia and 6 more
- Volunteers
- 459 people
- Sponsor
- Kodiak Sciences Inc
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Treatment of Diabetic Neuropathy With Liraglutide
The purpose of this trial is to explore whether liraglutide has a long term effect on clinical symptoms and biomarkers in patients with diabetic neuropathy.
- Trial name
- TODINELI (NCT02138045)
- Testing
- Liraglutide treatment
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital
Diabetic Neuropathy
Activity for Diabetic Polyneuropathy
The proposed study will randomize participants with diabetic peripheral neuropathy into two groups. One group of participants will receive standard-of-care counseling while the other group will undergo supervised exercise and…
- Trial name
- ADAPT (NCT02341261)
- Testing
- Standard Care Counseling, Supervised Exercise and Counseling
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Utah
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