Clinical trials: Diabetes-Related Complications
Diabetic Foot, Cardiopulmonary
Feasibility and Acceptability of Non Weight-bearing Physical Activity for People With Diabetic Foot Ulceration
Intervention in the form of a PA (physical activity) program combining aerobic, resistance, and flexibility exercises adapted for wearing a lower limb offloading device and limiting weight-bearing on the feet, with a duration of…
- Conditions
- Diabetic Foot, Cardiopulmonary, Physical Inactivity
- Trial name
- DB-ACTIV (NCT06092827)
- Testing
- Non weight-bearing physical activity program
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Université du Québec à Trois-Rivières
Diabetic Macular Edema
A Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME)
This is a randomized, masked, active-controlled, parallel-group, multi-center study that will assess the efficacy of ILUVIEN as a baseline therapy in the treatment of Center Involving DME (CI-DME).
- Trial name
- NEW DAY (NCT04469595)
- Testing
- Iluvien 0.19 MG Drug Implant, Aflibercept
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Alimera Sciences
Diabetic Nephropathy Type 2, Microalbuminuria Due to Type 2 Diabetes Mellitus
Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination
The aim of our work is to compare the antiproteinuric efficacy of ACEI monotherapy, Selective MRA monotherapy and their combination in mildly hypertensive patients with type 2 diabetes mellitus and microalbuminuria
- Trial name
- NCT04143412
- Testing
- Tritace (Ramipril 10 mg)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Beni-Suef University
Diabetic Neuropathies
Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
To determine if duloxetine 60 mg once daily can work up to 6 months in treating pain from Diabetic Neuropathy.
- Trial name
- NCT00322621
- Testing
- Duloxetine
- Where
- 19 sites in Brazil, France and 2 more
- Volunteers
- 216 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Diabetic Autonomic Neuropathy
Inspiratory Muscle Training in Patients With Autonomic Neuropathic
This study describes a controlled randomized clinical trial to evaluate the effect of inspiratory muscle training in patients with diabetic autonomic neuropathy.
- Trial name
- NCT00752440
- Testing
- Inspiratory muscle training (IMT)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Diabetic Foot Ulcers (DFU)
Effects of an Animated Mobile Application on Diabetic Foot Ulcer Management
This study was designed to evaluate the effect of education delivered through an animation-based mobile application on the knowledge level, self-efficacy, wound size, and metabolic parameters of individuals with diabetic foot…
- Trial name
- NCT06977048
- Testing
- Mobile Application-Based Educational Program, Standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetic Foot
Sealed Therapeutic Shoe as Treatment of Diabetic Foot Ulcers
Total contact casts (TCCs) are effective treatment of plantar diabetic foot ulcers because they effectively offload the ulcer and are non-removable, resulting in high adherence to using the device.
- Trial name
- NCT04085926
- Testing
- Sealed therapeutic shoe, Total contact cast
- Where
- 3 sites in Sweden
- Volunteers
- 4 people
- Sponsor
- Region Örebro County
Diabetic Foot, Diabetic Foot Ulcer
Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
The feasibility phase of the study was conducted to assess the feasibility of a novel, patient-centered, remote wound management system.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Wound; Foot, Wound Leg
- Trial name
- NCT05579743
- Testing
- Remote wound monitoring technology
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University
Diabetic Foot Ulcer
GrafixPL PRIME Evaluation Case Study
The investigators plan to evaluate healing in a cohort of patients with chronic wounds (n=40) that receive optimal treatment including serial wound debridement and off-loading with total contact casts or a boot and GrafixPL…
- Trial name
- NCT03742440
- Testing
- GrafixPL PRIME
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot Ulcer, Pressure Injury
A Dual-center Study Evaluating Clinical Acceptance of a NPWT Wound Care System
The purpose of this study is to determine if use of the Medela Invia Motion NPWT system supports acceptable progress towards the goal of therapy when treating patients with a variety of wound types during the evaluation period.
- Conditions
- Diabetic Foot Ulcer, Pressure Injury, Pressure Ulcer, Surgical Wound
- Trial name
- NCT04593693
- Testing
- Invia Motion Endure NPWT system
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Medela AG
Type 2 Diabetes Mellitus
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent…
- Trial name
- R2D2 (NCT01536808)
- Testing
- Cardiac RMI, Analysis telomere, Stress test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Neuropathy
Role of Indicator Test (Neuropad) in Detecting Diabetic Neuropathy
Diabetes mellitus can result in damage to the nerves supplying the feet. Various tests can be used to assess nerve damage but no tests so far have been used to assess loss of sweating which can lead to dry skin, fissuring and…
- Trial name
- NCT00895440
- Where
- United Kingdom
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Tameside Hospital NHS Foundation Trust
Diabetic Nephropathies
Serum Immunoglobulin (G) as a Marker of Diabetic Nephropathy
Diabetes mellitus is a chronic disease that affects 366 million people worldwide ( 6.4 % of the adult population ) and is expected to rise to 522 million by 2030 .
- Trial name
- NCT03212755
- Testing
- serum immunoglobulin G level
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus
Mobile Application to Enhance Diabetic Care
Prospective study to evaluate whether or not an internet application to coordinate and record diabetes management by the 1. diabetic patient/family caregiver 2. diabetic medical care team and 3.
- Trial name
- NCT01983917
- Testing
- Diabetes Mobile Application
- Where
- United States
- Sponsor
- University of California, Los Angeles
Diabetic Retinopathy
Biomarker of Diabetic Retinopathy
Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional.
- Trial name
- NCT05079399
- Testing
- Blood draw
- Where
- 3 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Acute Myocardial Infarction, Diabetes Mellitus
Association of Long-term Conditions With Survival Following Heart Attack in England and Wales
This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack…
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Peripheral Vascular Disease, Chronic Heart Failure
- Trial name
- NCT03037255
- Testing
- long term conditions
- Volunteers
- 693,633 people
- Sponsor
- Marlous Hall
Diabetic Retinopathy
Single-Cell Insights Into Diabetic Retinopathy Mechanisms
This study aims to uncover the cellular and molecular mechanisms of diabetic retinopathy through single-cell sequencing to identify new therapeutic targets.
- Trial name
- NCT06497608
- Volunteers
- 66 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Amputation, Diabetes Complications
Measuring Plantar Pressures in Diabetic Patients With Lateral Forefoot Amputation
This study aims to understand how pressure is placed on the bottom of the foot when people walk after a lateral forefoot amputation (for example, removal of the 5th toe).
- Conditions
- Amputation, Diabetes Complications, Foot Complications, Biomechanics
- Trial name
- NCT07865208
- Where
- 2 sites in Singapore
- Volunteers
- 70 people
- Sponsor
- Nanyang Technological University
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
Resistance Training in Patients With Diabetic Neuropathy
This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2).
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- NCT03252132
- Testing
- 12-week resistance training
- Where
- Denmark
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center
Diabetic Foot
Clinical Efficacy of Different Revision Times in the Reulceration Rate in Persons with Diabetes and Remission
The goal of this three arms randomized clinical trial is to compare different revision times in persons with diabetes at high risk of suffering a diabetic foot reulceration (patients in remission).
- Trial name
- Diatime (NCT06143215)
- Testing
- 4 weeks revision
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Universidad Complutense de Madrid
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