Clinical trials: Diabetic
Diabetes Mellitus
To Evaluate Clinical Efficacy and Safety of Diabetes-Specific Formula (Nutren Diabetes)
This study has a parallel, non-inferiority design, comparing the 24h AUC of Nutren Diabetes group with Fresubin Diabetes group at 2-4 days since the start of formal intervention.
- Trial name
- NCT05859165
- Testing
- Nutren Diabetes, Fresubin Diabetes
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity and Type 2 Diabetes
BMS-646256 in Obese and Overweight Type 2 Diabetics
This is a placebo-controlled, randomized, double-blind, parallel arm, multicenter, dose-ranging phase IIb trial to assess glycemic and weight loss efficacy and safety of BMS-646256 in overweight and obese patients with type 2…
- Trial name
- NCT00541567
- Testing
- ibipinabant
- Volunteers
- 600 people
- Sponsor
- Solvay Pharmaceuticals
Visual Impairment Due to Diabetic Macular Edema
Systemic VEGF Protein Dynamics Following Intravitreal Injections of Ranibizumab Versus Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of the study is to compare the effect of intravitreal injections of ranibizumab and aflibercept on systemic VEGF protein levels in DME patients in a detailed time course.
- Trial name
- TIDE DME (NCT02258009)
- Testing
- Ranibizumab, Aflibercept
- Where
- Germany
- Sponsor
- Novartis Pharmaceuticals
Diabetic Foot
Multi-Center, Prospective, Randomized Controlled Trial Evaluating SkinTE® in the Treatment of Wagner 2 DFUs
The purpose of this study is to assess the safety and efficacy of SkinTE for treatment of Wagner grade 2 diabetic foot ulcers.
- Trial name
- COVER DFUs (NCT05372809)
- Testing
- SkinTE, Control
- Where
- 13 sites in United States
- Volunteers
- 42 people
- Sponsor
- PolarityTE
Non-diabetic Obesity
PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults
This study aims to evaluate the efficacy and safety of PEG-rhGH Injection combined with Semaglutide Injection versus Semaglutide Injection monotherapy in improving body composition (lean body mass, fat mass, etc.) in non-diabetic…
- Trial name
- NCT06863363
- Testing
- PEG-rhGH Injection + Semaglutide Injection, Semaglutide Injection
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Diet
LoBAG30 Diet in Patients on Metformin
We will determine the metabolic response to a Low Biologically Available Glucose Diet (LoBAG30) in subjects currently receiving the maximum dose of metformin as monotherapy in whom the glycohemoglobin is not at an acceptable…
- Trial name
- LoBAG Diet (NCT00607867)
- Testing
- LoBAG30 diet, Control Diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes Mellitus, Hypertension
N-Acetylcysteine and Arginine Administration in Diabetic Patients
It has been demonstrated that the nitric oxide production is reduced in type 2 diabetic patients and that cardiovascular complications represent 80% of the causes of death in these patients.
- Trial name
- NACARGPAO (NCT00569465)
- Testing
- Arginine, Acetylcysteine
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Turin, Italy
Diabetes Mellitus, Diabetic Foot Ulcer
Effect of Electromagnetic Field Therapy and Customized Foot Insole on Peripheral Circulation and Ankle-Brachial Pressure Index in Patients With Diabetic Foot Ulcer
Diabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus, associated with poor peripheral circulation, neuropathy, and increased risk of lower-limb amputation.
- Trial name
- NCT07070544
- Testing
- Electromagnetic Field Therapy: • Frequency: 50 Hz • Intensity: 5-30 mT • Duration: 30 minutes/session • Frequency: 3 sessions/week for 8 weeks Customized Foot Insoles: • Individually tailored based on
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- South Valley University
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetics Using the Edmonton Protocol of Steroid Free Immunosuppression
This trial will study the ability of islet transplantation to restore glycemic control and achieve insulin independence in type 1 diabetic subjects with life-threatening hypoglycemia and unawareness, or recurrent hyperglycemia…
- Trial name
- NCT00133809
- Testing
- Transplantation of Human Islets
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Foot Ulcer, Diabetic, Patient Engagement
The Effect of Education on Patient Care Outcomes in Individuals With Diabetic Foot Ulcer
The aim of this study is to determine the effect of Social Cognitive Learning Theory-based education on patient participation, self-efficacy and wound healing in individuals with diabetic foot ulcers.
- Conditions
- Foot Ulcer, Diabetic, Patient Engagement, Self Efficacy, Wound Healing
- Trial name
- NCT06753799
- Testing
- The intervention group received training based on Social Cognitive Learning Theory.
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Fadime Koyuncu
Diabetic Foot Ulcer, Diabetes Mellitus
Efficacy of Adipose Tissue Derived Stem Cells for the Treatment of Diabetic Foot Ulcers
The aim of this study is to evaluate the therapeutic efficacy of uncultured adipose derived stromal vascular fraction (SVF) and cultured adipose derived stem cells (ASCs) both supplemented with platelet rich plasma (PRP) to treat…
- Conditions
- Diabetic Foot Ulcer, Diabetes Mellitus, Diabetic Foot, Diabetic Foot Infection
- Trial name
- NCT05610865
- Testing
- Control; Standard-of-care management, Only PRP injection, PRP + SVF injection
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- University of the Punjab
Peripheral Vascular Disease, Diabetic Foot
Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia
Critical limb ischemia is a condition where the blood circulation in the limbs, in most cases the legs, is decreased so that pain and non healing wounds ensue. Mostly, this is a sequel of arteriosclerosis and/or diabetes.
- Conditions
- Peripheral Vascular Disease, Diabetic Foot, Peripheral Arterial Occlusive Disease, Leg Ulcer
- Trial name
- BONMOT (NCT00434616)
- Testing
- Autologous bone marrow cell concentrate transplantation, saline injection
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Franziskus-Krankenhaus
Diabetic Nephropathy, Type 2 Diabetes
The Differential Effects of Diabetes Therapy on Inflammation
This study aims to determine if different diabetes treatments have different effects on inflammation; in particular, kidney inflammation.
- Trial name
- NCT02150707
- Testing
- Dipeptidyl-Peptidase IV Inhibitors, Glucagon-Like Peptide 1
- Where
- Ireland
- Volunteers
- 17 people
- Sponsor
- University College Dublin
Diabetic Nephropathy
"Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes"
Chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is a major cause of morbidity, commonly associated with persistent albuminuria and progressive renal decline.
- Trial name
- NCT07598864
- Testing
- Dapagliflozin +Finerenone arm, Dapagliflozin arm
- Where
- Bangladesh
- Volunteers
- 88 people
- Sponsor
- Chittagong Medical College
Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy
Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema
The purpose of this study is to test the efficacy of an 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular leakage and visual acuity for patients with recalcitrant diabetic macular edema.
- Conditions
- Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
- Trial name
- NCT01571232
- Testing
- dexamethasone intravitreal implant, intravitreal bevacizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Retina Macula Institute
Diabetic Gastroparesis, Idiopathic Gastroparesis
G-POEM for Treatment of Refractory Gastroparesis
This study is performed to assess the efficacy and outcomes of Gastric Per Oral Endoscopic Myotomy "G-POEM" in patients presenting with gastroparesis.
- Conditions
- Diabetic Gastroparesis, Idiopathic Gastroparesis, Gastroparesis Postoperative
- Trial name
- NCT02732821
- Testing
- Gastric Per Oral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Type 2 Diabetic
The Correlation Between Testosterone and Cortisol Level and Inflammatory Markers Levels in Type 2 Diabetic Men.
Many type 2 diabetic men have low serum testosterone levels. Our aim in this trial is to check if there is a correlation between serum or hair testosteron levels and serum or hair cortisol levels in type 2 diabetic men.
- Trial name
- BZMC (NCT02529306)
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Diabetic Macular Edema
DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical Impact
This is a Phase 2, doubled-masked, randomized study of the efficacy and safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in subjects with diabetic macular edema (DME).
- Trial name
- DA VINCI (NCT00789477)
- Testing
- Laser Photocoagulation, Intravitreal Aflibercept Injection
- Where
- 47 sites in United States, Austria and 1 more
- Volunteers
- 221 people
- Sponsor
- Regeneron Pharmaceuticals
Type 2 Diabetes
Efficacy, Usability Study of the GlucoTab System for Glycaemic Management in Type 2 Diabetic Patients at General Wards
Objective: To investigate the performance (safety) of the GlucoTab system for glycaemic management in non-critically ill patients with type 2 diabetes at general wards.
- Trial name
- NCT01932775
- Testing
- GlucoTab System
- Where
- Austria
- Volunteers
- 99 people
- Sponsor
- Medical University of Graz
Diabetes Type 1
Comparison of Insulin's Injection Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump
The current study focuses on terms of use of Insulin Aspart, fast analogue of human insulin and commonly used in the treatment of type 1 diabetes, where it obtained the marketing authorization for this indication.
- Trial name
- BOLUS (NCT02546401)
- Testing
- Insulin Aspart
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Brest