Clinical trials: Diabetic Cardiomyopathy
Simultaneous Pancreas-kidney Transplantation, Diabetic Cardiomyopathy
Assessment of Myocardial Injury in Simultaneous Pancreas and Kidney Transplantation
Diabetic cardiomyopathy( DCM) is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension．Trial to assess of myocardial injury in recipients of…
- Trial name
- AMI-SPK (NCT03904485)
- Testing
- cardiac magnetic resonance(CMR) T2 mapping
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin First Central Hospital
Ischemic Cardiomyopathy, Diabetes Mellitus
Alpha-lipoic Acid in Diabetic Patients With Ischemic Cardiomyopathy
The aim of this study is to investigate the effect of alpha-lipoic acid on inflammatory markers and cardiac fibrosis markers in diabetic patients with Ischemic Cardiomyopathy.
- Trial name
- NCT06056687
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Diabetic Cardiomyopathies
Single-center Clinical Study of Early Diagnosis of Diabetic Cardiomyopathy With FLIM
Diabetic Cardiomyopathy (DCM) is disease of myocardial structure and function which is independent of hypertension, coronary heart disease, heart valve abnormalities, and other types of heart disease.
- Trial name
- NCT04534894
- Testing
- fluorescence lifetime imaging microscopy
- Volunteers
- 243 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cardiopathy, Diabetes
Diabetic/Metabolic Cardiomyopathy: Prevalence and Phenotype
"Little is known about the prevalence, determinants and phenotypes of the cardiomyopathy associated with diabetes and/or metabolic syndrome.
- Conditions
- Cardiopathy, Diabetes, Metabolic Syndrome
- Trial name
- METAB-HEART (NCT05181631)
- Testing
- Biobanking
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Nitrate and Exercise-induced Cardiac Troponin T in Type 2 Diabetes
Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours…
- Trial name
- NO troponin (NCT01714674)
- Testing
- Dietary nitrate beverage, NaCl beverage
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes, High Blood Pressure
Polypill for Prevention of Cardiomyopathy
This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score.
- Trial name
- PolyPreventHF (NCT06143566)
- Testing
- Polypill, Combined prescription of the individual medications
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 1, Diabetic Cardiomyopathies
Preclinical Cardiomyopathy and Autonomic Function in Type 1 Diabetes
Type 1 diabetes mellitus is a chronic autoimmune disease, associated with an increased risk of cardiovascular diseases. The development of cardiomyopathy in type 1 diabetes, independent of hypertension and coronary heart disease…
- Conditions
- Diabetes Mellitus, Type 1, Diabetic Cardiomyopathies, Autonomic Neuropathy, Diabetic
- Trial name
- NCT03930004
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Roberto Léo da Silva
Diabetes Mellitus, Type 1
Alteration of Myocardial Deformations in Diabetes: Relationship to Micro-angiopathy
Despite careful monitoring of patients with diabetes, it is so far difficult to predict the occurrence of cardiac events in the evolution.
- Trial name
- ECHO-DIAB (NCT01220349)
- Testing
- Echocardiographic 2D strain analysis
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Bordeaux
Diabetes, Cardiomyopathy
Pilot Study to Assess the Proteome in Human Atrial Tissue
The concept of diabetic cardiomyopathy was initially defined more than 30 years ago, as cardiac failure in diabetic subjects in the absence of underlying coronary artery disease.
- Trial name
- NCT00591903
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
In and ex Vivo Mitochondrial Function of the Heart
It has been suggested that mitochondrial dysfunction might play a role in the development of diabetic cardiomyopathy. From animal studies, it has been suggested that an altered PPAR and PGC1 expression is involved in the reduced…
- Trial name
- 31P (NCT03049228)
- Testing
- 31P-MRS scan and cardiac MRI scan, Atrial biopsy for high-resolution respirometry, Blood analysis
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Maastricht University Medical Center
Diabetic, Cardiomyopathy
Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy
Diagnosis of diabetic cardiomyopathy is then retained, supposing a change in the coronary microcirculation linked to an endothelial dysfunction. Abnormalities of the myocardial metabolism is frequently associated.
- Trial name
- NCT01295385
- Testing
- NUCLEAR MAGNETIC RESONANCE IMAGING
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Type 2 Diabetes Mellitus
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent…
- Trial name
- R2D2 (NCT01536808)
- Testing
- Cardiac RMI, Analysis telomere, Stress test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes, Metabolic Syndrome
PBMC as Biomarkers of Diabetic Cardiomyopathy
Type 2 diabetes (T2D), especially when associated with metabolic syndrome (MS) is at high risk to develop heart failure with preserved ejection fraction (HFpEF) or heart failure with mildly reduced ejection fraction (HFmrEF), and…
- Conditions
- Type 2 Diabetes, Metabolic Syndrome, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
- Trial name
- MOBI (NCT05651919)
- Testing
- Blood test, quality of life Questionnaire, Diet habits questionnaire
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Cardiomyopathy, Diabetes Mellitus Type 2
REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrs
Pathophysiology of diabetic cardiomyopathy (DCM) is yet unclear and gender differences at baseline and a specific treatment have not been indicated.
- Trial name
- RECOGITO (NCT01803828)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza
Hypertrophic Cardiomyopathy
Incidence of Hypertrophic Cardiomyopathy in Infants of Diabetic Mothers Attending in NICU at Assiut University Children Hospital During One Year
To evaluate all full term infants of diabetic mother for the presence of hypertrophic cardiomyopathy who admitted in NICU at Assiut University Children Hospital and to follow up of these cases after 6 months for recovery.
- Trial name
- NCT06048562
- Testing
- echocardiography
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diabetic Cardiomyopathy
Impact of Prediabetes on Acute Coronary Syndrome
Diabetes mellitus is one of the chronic non-communicable diseases which have emerged as a leading global health problem. According to the International Diabetes Federation Atlas guideline report, currently, there are 352 million…
- Trial name
- NCT05102851
- Testing
- Troponin, Lipid profile, HBA1C, Fasting blood glucose level, Creatinine, Body Mass Index
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Cardiomyopathy
Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass Surgery
The overall purpose of this study is to evaluate the effect of gastric bypass surgery-induced weight loss on the heart's function and on fat deposits in the heart muscle.
- Trial name
- DRTC (NCT01067209)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean Patients With Type 2 Diabetes
This observational study will evaluate the cardiovascular effects of sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) and glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) in Korean adults with type…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases, Stage B Heart Failure
- Trial name
- NCT07770737
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Dongtan Sacred Heart Hospital
Diabetic Cardiomyopathy
Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in Diabetes
Diabetes increases the risk of heart failure. This is mainly due to a disease of the blood vessels supplying the heart muscle and/or high blood pressure, but abnormal metabolism may also contribute.
- Trial name
- DDCM (NCT00628056)
- Testing
- Perhexiline
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University Hospital Birmingham
Diabetic Cardiomyopathies, Heart Failure
Diabetic Cardiomyopathy and Heart Failure
This study will demonstrate the beneficial effects of ketone bodies in type 1 diabetes (T1D) patients and will have significant translational applications to prevent serious metabolic conditions such as T1D induced diabetic…
- Trial name
- NCT05571865
- Testing
- Probiotic
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville