Clinical trials: Diabetic Feet
Lower Extremity or Diabetic Foot Ulcers, Bacterial Infection
Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm
This is a prospective study of Veterans with chronic lower extremity or diabetic foot ulcers who will be randomized to either a Larval Debridement Therapy group (Biobags every 4 days x 2 applications) or a Sharp Debridement…
- Trial name
- NCT02294175
- Testing
- Larval Debridement Therapy, Bedside Sharp Debridement
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- North Florida Foundation for Research and Education
Diabetic Foot Ulcers
Comparative Study of 3 Dose Regimens of BioChaperone to Becaplermin Gel for the Treatment of Diabetic Foot Ulcer
This is an open-label, active-control, multicentre, parallel group, randomised and dose-finding efficacy and safety study. Compare the efficacy and safety of BioChaperone PDGF-BB applied at 12.5 µg/cm² every two days for up to 20…
- Trial name
- NCT01098357
- Testing
- Biochaperone PDGF-BB Low dose, Biochaperone PDGF-BB High dose, Regranex
- Where
- 7 sites in India
- Volunteers
- 192 people
- Sponsor
- Virchow Group
Determine Effectiveness of Theraskin in the Treatment of DFU and VLU
Clinical Trial to Examine Effectiveness of a Human Allograft for Treatment of DFU and VLU
Retrospective clinical study of 188 patients to examine effectiveness of human cryopreserved allograft in the treatment of diabetic foot ulcers and venous leg ulcers
- Trial name
- NCT03999281
- Testing
- Human Allograft (Theraskin)
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Solsys Medical LLC
Diabetic Foot Ulcer
Study Assessing Safety and Efficacy of B-cure Laser Treating Diabetic Chronic Wounds
For centuries, light has been a well-known and effective healing method. In the beginning of the 20th century there was a first attempt to condense light energy and distribute it in higher levels, a use that was successfully…
- Trial name
- NCT01493895
- Testing
- standard hoem treatment, LLLT-808 B-cure laser machine
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot
Obliterating Diabetic Microangiopathy of the Diabetic Foot
The purpose of this study will be the assessment of microangiopathy determined by the increase of capillary basement membrane thickness and decrease of capillary lumen area in the foot ulcer of 30 neuropathic and 30 neuroischemic…
- Trial name
- NCT02610036
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Multimedica
Peripheral Arterial Disease(PAD), Arterial Occlusive Disease
Follow-up Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-L)
The goal of this observational study is to learn about the long-term effects of Donaperminogene Seltoplasmid Injection (NL003) in participants who have been received drug NL003 or placebo at least one dose from the parent phase…
- Conditions
- Peripheral Arterial Disease(PAD), Arterial Occlusive Disease, Arteriosclerosis Obliterans, Thromboangiitis Obliterans
- Trial name
- NCT07023965
- Testing
- NL003
- Where
- 5 sites in China
- Volunteers
- 542 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Diabetic Foot
Study of Subjects With Diabetic Foot Ulcer (DFU)
Foot ulceration is a common and costly complication of diabetes. GSK1278863 is a topical drug, which is being developed to treat wounds associated with DFU.
- Trial name
- NCT03153007
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Diabetic Foot Ulcer
The Effect of Breathing Exercise and Pressurized Cold Application on Pain and Anxiety During Sharp Debridement
In our planned study, it is envisaged that patients who receive breathing exercises and pressurized cold application will experience a decrease in the level of pain they feel during the debridement process, a decrease in their…
- Trial name
- NCT06886633
- Testing
- Breathing exercise, Experimental: Pressurized Cold Application Group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Diabetic Foot Ulcer (DFU), Ulcer Foot
Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs
The purpose of this study is to evaluate the efficacy of four dehydrated complete human placental membrane, also defined as Cellular, Acellular, Matrix-like Products/skin substitutes, plus SOC versus SOC alone in achieving…
- Conditions
- Diabetic Foot Ulcer (DFU), Ulcer Foot, Diabetic Foot, Foot Ulcer
- Trial name
- CAMPSTIM (NCT06449638)
- Testing
- Standard of Care, Revita, Relese
- Where
- 5 sites in United States
- Volunteers
- 272 people
- Sponsor
- StimLabs
Diabetic Foot Ulcers, Pressure Ulcers
Evaluation of the Effects of HP828-101 Versus Standard of Care in the Management of Partial or Full Thickness Wounds
To compare HP828-101 to standard of care for the management of partial or full thickness wounds
- Trial name
- NCT00971048
- Testing
- HP828-101, Hydrogel/Hydrocolloid
- Where
- 11 sites in United States
- Volunteers
- 88 people
- Sponsor
- Healthpoint
Diabetic Foot Ulcer, Venous Leg Ulcer
Cold atmOspheric plaSMa Therapy Versus standArd Wound Care in Diabetic Foot and Venous Leg ulcerS
Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) pose a major health burden to the patients but also to the healthcare system because of their distorted healing capacity.
- Trial name
- COSMAS (NCT07251426)
- Testing
- COLD ATMOSPHERIC PLASMA
- Volunteers
- 494 people
- Sponsor
- Olaf Bakker
Diabetic Foot Ulcer (DFU)
Askina Calgitrol Paste Diabetic Foot Ulcers
The purpose of this study is to assess the efficacy of Askina® Calgitrol® Paste in reducing local infection in subjects treated for mildly infected Diabetic Foot Ulcers (DFU) with Askina® Calgitrol® Paste.
- Trial name
- NCT01912092
- Testing
- Askina Calgitrol paste
- Where
- 2 sites in Italy
- Volunteers
- 22 people
- Sponsor
- BBraun Medical SAS
Diabetic Foot Ulcer of Neuropathic Origin
The TRAfermin in Neuropathic Diabetic Foot Ulcer Study - Southern Europe The TRANS-South Study
Trafermin is a recombinant human basic fibroblast growth factor (bFGF; original development code, KCB-1), which is manufactured by genetic engineering using Escherichia coli by Kaken Pharmaceutical Co., Ltd. (Tokyo, Japan).
- Trial name
- TRANS-South (NCT01217463)
- Testing
- Trafermin 0.01% spray
- Where
- 24 sites in Czechia, France and 2 more
- Volunteers
- 201 people
- Sponsor
- Olympus Biotech Corporation
Diabetic Foot
Effectiveness of Remote Foot Temperature Monitoring
Diabetic foot ulcers are common, debilitating, and costly complications of diabetes, disproportionately impacting Black and rural Veterans.
- Trial name
- STOP (NCT05728411)
- Testing
- Remote foot temperature monitoring system, Enhanced usual care
- Where
- 4 sites in United States
- Volunteers
- 379 people
- Sponsor
- VA Office of Research and Development
Diabetic Foot Ulcers
Hyperbaric Oxygen, Oxidative Stress, NO Bioavailability and Tissue Oxygenation
Hyperbaric oxygen therapy (HBOT) increases tissue oxygenation and serves as an adjunct therapy for diabetic wounds. However, some patients have insufficient increase or even paradoxical decrease in tissue O2 due to…
- Trial name
- NCT00463671
- Testing
- N-acetylcysteine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Diabetic Foot Ulcer
Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers
To investigate the effect of Dipeptidyl Peptidase 4 Inhibition on wound healing in patients with diabetic foot ulcers, the investigators randomly divided the participants into two groups: saxagliptin with regular treatment…
- Trial name
- DPP4i (NCT02742233)
- Testing
- saxagliptin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Long Min,MD
Diabetes, Foot Ulcer
Efficacy and Safety Study of DERMAGEN® vs Conventional Treatment to Treat Diabetic Neuropathic Foot Ulcer
It is estimated that 300 million people worldwide will have diabetes by the year 2025. About 12 percent of those with diabetes will have had a foot ulcer, which is a major source of morbidity, concern, and cost.
- Trial name
- DERMAGEN® (NCT00521937)
- Testing
- Dermagen®
- Where
- 7 sites in France
- Volunteers
- 388 people
- Sponsor
- Laboratoires Genévrier
Diabetic Foot Ulcers
Phase IV Study to Evaluate the Efficacy of AMNIOEXCEL in Diabetic Foot Ulcers
The primary goal of the study is to demonstrate the increased rate of complete wound closure by AMNIOEXCEL® compared to routine care in patients with chronic diabetic foot ulcers
- Trial name
- NCT02209051
- Testing
- AMNIOEXCEL, Standard of Care, Diabetic Foot Ulcers
- Where
- 8 sites in United States
- Volunteers
- 29 people
- Sponsor
- Integra LifeSciences Corporation
Foot Ulcer, Diabetic
Health Economic Assessment of Lower Extremity Diabetic (HEALED) Ulcers With PriMatrix
The objective of this study is to compare the effectiveness of PriMatrix Moist Wound Therapy (MWT) with Standard of Care MWT for the treatment of chronic diabetic foot ulcers in subjects with diabetes mellitus and without…
- Trial name
- HEALED (NCT01729286)
- Testing
- PriMatrix Moist Wound Therapy, Standard of Care Moist Wound Therapy
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 92 people
- Sponsor
- Integra LifeSciences Corporation
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