Clinical trials: Diabetic Foot Infections
Diabetic Foot Infection, Osteomyelitis
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations.
- Conditions
- Diabetic Foot Infection, Osteomyelitis, Photo Antimicrobial Chemotherapy
- Trial name
- NCT03380403
- Testing
- PDT, Ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Diabetic Foot, Osteomyelitis
Risk Factors for Three Critical Stages of the Diabetic Foot Infections
In this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures.
- Trial name
- NCT02736253
- Where
- Turkey (Türkiye)
- Volunteers
- 379 people
- Sponsor
- Ege University
Foot Ulcer, Diabetic, Infection
Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers
This is a phase 3, randomized, controlled, blinded, multicenter study conducted in 3 parallel cohorts of diabetic patients with at least 1 infected foot ulcer.
- Trial name
- COACT-2 (NCT02447172)
- Testing
- Gentamicin Collagen sponge
- Where
- 91 sites in United States, Australia and 14 more
- Volunteers
- 524 people
- Sponsor
- Innocoll
Diabetic Foot Infection
Real-World Efficacy and Safety Analysis of Omadacycline for the Treatment of Diabetic Foot Infections and Acute Osteomyelitis
This will be a prospective, open-label, two-center study to assess the safety of omadacycline use in the treatment of hospitalized subjects with moderate to severe DFI with or without Acute osteomyelitis (AOM) who are at a high…
- Trial name
- NCT04714411
- Testing
- Omadacycline
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Methodist Health System
Toenail Fungal Infection, Cellulitis
A Subjective Observational Study of Patients Using Medicated Footbath/Footwash Treatment in Podiatry Care
The purpose of this study is to evaluate the level of relief perceived by patients using medicated footbath/footwash with or without an oral medication for the treatment of podiatry issues.
- Conditions
- Toenail Fungal Infection, Cellulitis, Pitted Keratolysis, Diabetic Foot Ulcer
- Trial name
- NCT03781024
- Testing
- Footwash
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Data Collection Analysis Business Management
Diabetic Foot Infection
Safety and Efficacy Study of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults With Moderate or Severe Diabetic Foot Infections (DFI)
This is a Phase 3, multicenter, randomized, double-blind, safety and efficacy study of contezolid acefosamil (IV)/contezolid (PO) compared with linezolid (IV and PO) administered for a total of 14 to 28 days in adult subjects…
- Trial name
- NCT05369052
- Testing
- contezolid acefosamil (IV)/contezolid (PO), Linezolid (IV and PO)
- Where
- 14 sites in United States, Bulgaria and 6 more
- Volunteers
- 865 people
- Sponsor
- MicuRx
Diabetic Foot Ulcer, Diabetes Mellitus
Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification
The purpose of this study is to evaluate the role of rapid diagnosis of pathogens in treatment of infection and wound healing in diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Diabetes Mellitus, Wound
- Trial name
- NCT06569238
- Testing
- Conventional bacterial culture, Rapid diagnostic group using mNGS technology
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Diabetes, Diabetic Foot
Assessing the Efficacy of Anti-staphylococcal Phages in the Management of Infected Foot Ulcers in Diabetes
Work Package 1: Observational cohort pilot safety study Work Package 2: Randomised, double-blind, placebo controlled pilot study Work Package 3: Observer-blind pilot RCT
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Infection
- Trial name
- PDFI (NCT04289948)
- Testing
- Phage
- Where
- United Kingdom
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Diabetic Foot Infections
Diabetic Foot Infection Antibiotic Study
This is a pilot study to explore the effects of long-course versus short course antibiotics on wound healing in surgically managed diabetic foot infections.
- Trial name
- NCT01539811
- Testing
- Surgical incision and drainage of diabetic foot infection, Short course antibiotics, Long course antibiotics
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Prisma Health-Upstate
Diabetic Foot Infections
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis
Diabetic foot osteomyelitis (DFO) is a bone infection of the foot that can occur in people with diabetes and may lead to serious complications, including amputation. Diagnosing DFO can be difficult.
- Trial name
- NCT07828691
- Testing
- 18F-FDG PET/CT
- Where
- 4 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Jewish General Hospital
Diabetes Mellitus, Insulin Resistance
Insulin Infusion Diabetes Ulcer
Normoglycemia is important for the outcome of surgical and medical conditions. Insulin infusions have been studied to achieve normoglycemia during these circumstances and have proved to be useful.
- Conditions
- Diabetes Mellitus, Insulin Resistance, Hyperglycemia, Surgery
- Trial name
- IINDU (NCT00700154)
- Testing
- Insulin infusion
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Diabetic Foot Ulcer, Diabetic Foot
Treatment of Chronic Diabetic Foot Ulcers by Minimally Invasive Surgery
Despite the development of the control of DM and the great interest for the complications of the disease, even today the diabetic foot represents a challenge for the orthopaedic surgeon.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetic Foot Infection, Diabetic Foot Ulcer Neuropathic
- Trial name
- DiabeticMIS1 (NCT03010215)
- Testing
- Distal Metatarsal Minimally invasive Osteotomy (DMMO)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Foot Infections in Diabetic Patients
Comparative Study of Ertapenem Versus Another Antibiotic in the Treatment of Diabetic Foot Infections in Adults (0826-034)
This study will compare the efficacy, safety and tolerability of intravenous ertapenem versus another intravenous antibiotic in the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT00229112
- Testing
- MK0826, ertapenem sodium / Duration of Treatment - 24 weeks, Comparator: Piperacillin/Tazobactam / Duration of Treatment - 24 weeks
- Volunteers
- 400 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Diabetic Foot Infection, Non-healing Wound
Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU)
It is hypothesized that application at 4-week or greater intervals of the human placental umbilical cord tissue TTAX01 to the surface of a well debrided, complex diabetic foot ulcer (DFU) will, with concomitant management of…
- Conditions
- Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
- Trial name
- NCT04176120
- Testing
- TTAX01, Standard Care
- Where
- 16 sites in United States
- Volunteers
- 220 people
- Sponsor
- BioTissue Holdings, Inc
Foot Ulcer, Diabetic, Diabetic Foot
Safety and Efficacy Study of DSC127 in Treating Subjects With Diabetic Ulcers
The purpose of this study is to assess if the experimental drug, DSC127, is safe, how well it can be tolerated, and how different doses effect the healing of the chronic foot ulcers in diabetic subjects.
- Trial name
- NCT00796744
- Testing
- NorLeu3-A(1-7) in a gel formulation
- Where
- 12 sites in United States
- Volunteers
- 78 people
- Sponsor
- US Biotest, Inc.
Diabetic Foot Infection
Study by Metagenomics and Culturomicsapproaches of Bacterial and Viral Flora of Diabetic Foot Infection
This work also highlights the presence of an unknown virus double-stranded DNA. In this project we propose 1) incorporating a bank of 150 samples from patients with diabetic foot infection in grades 2-4; 2) to study the microbial…
- Trial name
- NCT02565940
- Testing
- biopsy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infection; Diabetic Foot
Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)
This study compared ertapenem sodium to piperacillin/tazobactam sodium for the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT01370616
- Testing
- Ertapenem sodium, Piperacillin/tazobactam sodium, Amoxicillin/clavulunate potassium
- Volunteers
- 565 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetic Foot Ulcer
Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With An Uninfected Foot Ulcer
The purpose of this study is to determine the safety and efficacy of the topical gentamicin collagen sponge (gentamicin sponge) combined with standard of care (daily wound care, off-loading, diabetic control and debridement by a…
- Trial name
- NCT00658957
- Testing
- gentamicin-collagen sponge
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Innocoll
Abscess, Wound Infection
Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
Patients, who are considered suitable by their physicians to take part in this research, will have a physical examination (including an Electrocardiogram (ECG)), blood and urine samples taken, as well as a sample of the…
- Conditions
- Abscess, Wound Infection, Diabetic Foot, Ulcer
- Trial name
- NCT00402727
- Testing
- Moxifloxacin (Avelox, BAY12-8039), Piperacillin/Tazobactam & Amoxicillin/Clavulanic acid
- Where
- 123 sites in Austria, Belgium and 18 more
- Volunteers
- 813 people
- Sponsor
- Bayer