Clinical trials: Diabetic Macular Oedema
Diabetic Macular Edema
Oxulumis® Suprachoroidal Microcatherization of Triesence® in Diabetic Macular Edema
The purpose of this clinical trial is to evaluate the safety and tolerability of suprachoroidal microcatheterization with the Oxulumis® device for a randomized treatment with two dose levels of Triesence® in subjects with…
- Trial name
- CAPE (NCT05512962)
- Testing
- Triamcinolone Acetonide, Semi-automated Suprachoroidal Microcatheter
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Oxular Limited
Retinal Disease
Assessment of Novel Intraocular Injection Guide
To determine if a novel intraocular injection guide (IIG) reduces patient discomfort during and after intravitreal injections.
- Trial name
- NCT02315170
- Testing
- intraocular injection guide, standard lid speculum
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maturi, Raj K., M.D., P.C.
Diabetic Macular Edema (DME)
Safety, Tolerability and Evidence of Activity Study of UBX1325 in Patients With Diabetic Macular Edema (BEHOLD)
This study is intended to assess the exposure, safety, biological activity, and durability of UBX1325, a phosphate pro-drug, and its active parent molecule (UBX0601) following a single intravitreal (IVT) injection of UBX1325 in…
- Trial name
- NCT04857996
- Testing
- UBX1325
- Where
- 22 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- Unity Biotechnology, Inc.
Diabetic Macular Edema
Safety and Efficacy by Multiple Injection of KH902 in Patients With Diabetic Macular Edema (DME)
This study is designed to access the safety and efficacy of multiple injections of KH902 in patients with Diabetic Macular Edema (DME).
- Trial name
- Frontier-1 (NCT01324869)
- Testing
- KH902
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
DME, Diabetic Macular Edema
Study of CU06-1004 in Patients With Daibetic Macular Edema
This phase 2b trial is a randomized, double-masked, parallel-group, multi-center study in approximately 156 patients with Diabetic Macular Edema to evaluate the efficacy and safety of CU06-1004 orally administered once daily for…
- Conditions
- DME, Diabetic Macular Edema, Diabetic Macular Edema (DME)
- Trial name
- NCT07459829
- Testing
- CU06-1004
- Volunteers
- 156 people
- Sponsor
- Curacle Co., Ltd.
Diabetic Retinopathy
Lucentis (Ranibizumab) in Diabetic Macular Oedema: a Treatment Evaluation
This exploratory study will compare the effects of ranibizumab treatment with conventional macular laser therapy for patients with diabetic macular oedema.
- Trial name
- LUCIDATE (NCT01223612)
- Testing
- Ranibizumab, Modified ETDRS laser
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Diabetic Macular Edema
Describing Patient With DME, Their Patient Journey and Disease Progression
This study aims to characterize patients with diabetic macular edema (DME), their progression, the treatment received and associate the functional and physiological outcomes related to the treatment.
- Trial name
- NCT05966753
- Where
- United States
- Volunteers
- 221,004 people
- Sponsor
- Boehringer Ingelheim
Diabetic Macular Edema
A Study to Assess the Use of Artificial Intellignce to Predict Eye Treatment Changes in Adult Participants With Diabetic Macular Edema
This study is to assess the use of Artificial intellignce (AI) to predict eye treatment changes in adult participants with diabetic macular edema (DME).
- Trial name
- OPTIMAL-3 (NCT07604545)
- Sponsor
- AbbVie
Diabetic Retinopathy, Diabetic Macular Edema
PROMINENT-Eye Ancillary Study (Protocol AD)
Despite improved glycemic and systemic control for many patients with diabetes, over the past several decades, diabetic retinopathy (DR) develops and progresses in a large proportion of patients, and visual loss from diabetic eye…
- Trial name
- NCT03345901
- Testing
- Pemafibrate
- Where
- 71 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Type 1 or 2 With Diabetic Retinopathy
Incidence of Macular Edema After Panretinal Photocoagulation (PRPC) Performed in a Single Session Versus Four Sessions in Diabetic Patients.
The aim of this study is to show that PRPC performed in a single session using a Pascal laser leads to better management of the disease (better rate of regression of neovessels, lower risk of a loss of visual acuity in the long…
- Trial name
- Pascal (NCT01766362)
- Testing
- PRPC using Pascal laser
- Where
- 3 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetic Macular Edema, Diabetic Retinopathy
A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
A Phase 2 study to determine the safety and preliminary efficacy of intravitreal injections of AVD-104, a novel glyco-mimetic nanoparticle, in reducing macular edema associated with diabetic retinopathy.
- Trial name
- NCT06181227
- Testing
- AVD-104
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Aviceda Therapeutics, Inc.
Diabetic Macular Edema
Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistant Diabetic Macular Oedema
Diabetic macular oedema (DME) is the main cause of visual impairment (or visual acuity) in patients with diabetic retinopathy, as it leads to progressive thickening of the retina, which in the long term leads to progressive death…
- Trial name
- EMMA (NCT04910503)
- Testing
- Dexamethasone intravitreal implant, Fluocinolone Acetonide Intravitreal Implant
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetic Macular Edema
Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema
prospective study evaluating the impact of subthreshold micropulsed laser on the number of Aflibercept injections when used as an adjuvant therapy in eyes with diabetic macular edema.
- Trial name
- MPL (NCT03866746)
- Testing
- Aflibercept Injection, micropulsed yellow laser
- Where
- Kuwait
- Volunteers
- 51 people
- Sponsor
- Al Hadi Hospital
Diabetic Macular Edema
Rapid Structural and Functional Improvements in Following 0.19 mg Fluocinolone Acetonide (FAc) Implant in Diabetic Macular Edema Patients With Poor Visual Acuity: 12-month Audit Results From United Arab Emirates
The Health Authority - Abu Dhabi (HAAD) approved the reimbursement of the slow release FAc implant (ILUVIEN) and it is now available for the treatment of diabetic macular edema (DME) in persons who have been previously treated…
- Trial name
- NCT03590587
- Testing
- 0.19 mg fluocinolone acetonide (FAc) implant
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Benha University
Diabetic Macular Edema(DME)
The Study to YD312 Tablet in Patients With Diabetic Macular Edema
This study objectives is to evaluate the efficacy of YD312 to improve visual acuity in patients with diabetic macular edema (DME) compared to placebo and determine optimal dose of phase 2b study.
- Trial name
- NCT03635814
- Testing
- YD312 50mg, YD312 150mg, YD312 350mg
- Where
- 20 sites in United States, South Korea
- Volunteers
- 100 people
- Sponsor
- YD Global Life Science Co., Ltd.
Diabetic Retinopathy, Non Proliferative Diabetic Retinopathy
Randomized, Controlled Study to Investigate the 12-month Efficacy and Safety of Resveratrol Vitamin Supplements in Patients With Non-proliferative Diabetic Retinopathy Without Center Involved Diabetic Macular Edema (REVOLUTION Study)
This randomized, controlled study aims to investigate the efficacy and safety of resveratrol-containing vitamin supplements in patients with non-proliferative diabetic retinopathy (NPDR) without center-involved diabetic macular…
- Conditions
- Diabetic Retinopathy, Non Proliferative Diabetic Retinopathy, Prospective Study
- Trial name
- REVOLUTION (NCT07868458)
- Testing
- Resveratrol-Containing Vitamin Supplement
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Micropulse Laser, Treatment
Micropulse Laser in Treatment of Initial and Refractory Cases of Center-Involved Diabetic Macular Edema
This study aims to evaluate the effect of subthreshold 577 nm micropulse laser photocoagulation in the treatment of initial and refractory cases of Center-Involved Diabetic Macular Edema.
- Conditions
- Micropulse Laser, Treatment, Initial, Refractory
- Trial name
- NCT07295704
- Testing
- Micropulse Laser
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- The General Authority for Teaching Hospitals and Institutes
Diabetic Macular Edema, Diabetes Mellitus, Type 2
Advanced Glycation End Products Are Associated With Diabetic Macular Edema
Diabetic macular edema can develop at all stages of diabetic retinopathy, causing visual impairment and blindness. Modern diets are high in advanced glycation end products (dAGEs), derived from processing methods, exerting a…
- Trial name
- NCT04468152
- Testing
- Dietary habits and intake
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Diabetic Macular Edema, Diabetic Retinopathy
Intravitreal Dexamethasone vs Bevacizumab in Aboriginal People With DMO
DMO is the most common cause of visual loss in people with diabetes. Regular injections of bevacizumab (Avastin) given as frequently as every month remain the current standard of care for centre-involving DMO; however, this…
- Trial name
- OASIS (NCT04619303)
- Testing
- Dexamethasone intravitreal implant, Bevacizumab Injectable Product
- Where
- 13 sites in Australia
- Volunteers
- 59 people
- Sponsor
- Lions Eye Institute, Perth, Western Australia
Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
The study will compare the safety of ophthalmic bevacizumab in vials versus pre-filled syringes in subjects diagnosed with a retinal condition that would benefit from treatment with intravitreal injection of bevacizumab…
- Conditions
- Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
- Trial name
- NORSE SEVEN (NCT05112861)
- Testing
- bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Outlook Therapeutics, Inc.